Synthesis, Characterization, and Anticancer Activity (MCF-7) of Some Acetanilide-based Heterocycles
Corresponding Author
Ehab Abdel-Latif
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
E-mail: [email protected]Search for more papers by this authorEman M. Keshk
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorAbdel-Galil M. Khalil
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorAli Saeed
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorHeba M. Metwally
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorCorresponding Author
Ehab Abdel-Latif
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
E-mail: [email protected]Search for more papers by this authorEman M. Keshk
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorAbdel-Galil M. Khalil
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorAli Saeed
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorHeba M. Metwally
Department of Chemistry, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt
Search for more papers by this authorAbstract
A series of some novel 4-(N-substituted amino)-acetanilide scaffolds was synthesized through the nucleophilic substitution reactions of the highly versatile N-(4-acetamidophenyl)-2-chloroacetamide (3) with various types of nucleophilic reagents such as benzothiazole-2-thiol, ethyl 2-mercaptoacetate, 4,6-dimethyl-2-mercapto-nicotinonitrile, various thiocarbamoyl derivatives, ammonium thiocyanate, 3-cyano-4,6-dimethyl-5-arylazopyridin-2-ones, and malononitrile. The synthesized 4-(N-substituted amino) acetanilide scaffolds were characterized by spectral analyses and assayed in vitro for breast anticancer activity. 2-(4-Acetamidophenylaminocarbonyl)-3-amino-thiophenes 11, 13a, and 13b showed the highest cytotoxic activity.
References and Notes
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