Design, Synthesis and SAR Study of Novel Spiro [Pyrimido[5,4-b]Quinoline-10,5′-Pyrrolo[2,3-d]Pyrimidine] Derivatives as Promising Anticancer Agents
Asha V. Chate
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorSagar P. Kamdi
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAmruta N. Bhagat
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorChetan K. Jadhav
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAmol Nipte
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAniket P. Sarkate
Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorShailee V. Tiwari
Y.B. Chavan College of Pharmacy, Razabaug, Aurangabad, Maharashtra, 431001 India
Search for more papers by this authorCorresponding Author
Charansingh H. Gill
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
*E-mail: [email protected]Search for more papers by this authorAsha V. Chate
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorSagar P. Kamdi
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAmruta N. Bhagat
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorChetan K. Jadhav
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAmol Nipte
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorAniket P. Sarkate
Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
Search for more papers by this authorShailee V. Tiwari
Y.B. Chavan College of Pharmacy, Razabaug, Aurangabad, Maharashtra, 431001 India
Search for more papers by this authorCorresponding Author
Charansingh H. Gill
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, 431004 India
*E-mail: [email protected]Search for more papers by this authorAbstract
Novel spiro [pyrimido[5,4-b]quinoline-10,5′-pyrrolo[2,3-d]pyrimidine] derivatives were designed and synthesized, and their chemical structures were confirmed by IR, NMR, elemental analysis, and mass spectral analysis. The anticancer activities of the newly synthesized compounds were evaluated in vitro against four human cancer cell lines including A431, PC-3, MCF-7, and MCF-10A by MTT assay. The screening results showed that three compounds (4m, 4q, and 4s) exhibited potent cytotoxic activities with IC50 values between 7.82 and 9.88 μM against human breast cancer cell line (MCF-7). Further in vitro studies revealed that inhibition of Sunitinib could be the possible mechanism of action of these molecules.
Supporting Information
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