Volume 8, Issue 9 pp. 740-754
Full Article

Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation

Cleber Ferraresi

Cleber Ferraresi

Laboratory of Electrothermophototherapy, Department of Physical Therapy, Federal University of Sao Carlos, SP, Brazil

Post-Graduation Program in Biotechnology, Federal University of Sao Carlos, SP, Brazil

Optics Group, Physics Institute of Sao Carlos, University of São Paulo, Sao Carlos, SP, Brazil

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

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Nivaldo Antonio Parizotto

Nivaldo Antonio Parizotto

Laboratory of Electrothermophototherapy, Department of Physical Therapy, Federal University of Sao Carlos, SP, Brazil

Post-Graduation Program in Biotechnology, Federal University of Sao Carlos, SP, Brazil

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Marcelo Victor Pires de Sousa

Marcelo Victor Pires de Sousa

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

Laboratory of Radiation Dosimetry and Medical Physics, Institute of Physics, Sao Paulo University,, SP, Brazil

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Beatriz Kaippert

Beatriz Kaippert

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

Federal University of Rio de Janeiro, RJ, Brazil

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Ying-Ying Huang

Ying-Ying Huang

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

Department of Dermatology, Harvard Medical School, Boston, MA, USA

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Tomoharu Koiso

Tomoharu Koiso

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

Graduate School Biomedical Engineering, Tohoku University, Japan

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Vanderlei Salvador Bagnato

Vanderlei Salvador Bagnato

Optics Group, Physics Institute of Sao Carlos, University of São Paulo, Sao Carlos, SP, Brazil

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Michael R. Hamblin

Corresponding Author

Michael R. Hamblin

Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114 USA

Department of Dermatology, Harvard Medical School, Boston, MA, USA

Harvard-MIT Division of Health Science and Technology, Cambridge, MA, USA

Corresponding author: e-mail: [email protected]

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First published: 06 November 2014
Citations: 58

Abstract

Light-emitting diode therapy (LEDT) applied over the leg, gluteus and lower-back muscles of mice using a LED cluster (630 nm and 850 nm, 80 mW/cm2, 7.2 J/cm2) increased muscle performance (repetitive climbing of a ladder carrying a water-filled tube attached to the tail), ATP and mitochondrial metabolism; oxidative stress and proliferative myocyte markers in mice subjected to acute and progressive strength training. Six bi-daily training sessions LEDT-After and LEDT-Before-After regimens more than doubled muscle performance and increased ATP more than tenfold. The effectiveness of LEDT on improving muscle performance and recovery suggest applicability for high performance sports and in training programs.

image

Positioning of the mice and light-emitting diode therapy (LEDT) applied on mouse legs, gluteus and lower-back muscles without contact.

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