Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri
Jin-Qiu You
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorYun-Qi Jin
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorMeng-Yu Li
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorBo-Chao Zhang
Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China
Search for more papers by this authorXin-Yu Sun
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
Search for more papers by this authorChun-Yong Ding
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorJing-Ya Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
Search for more papers by this authorCorresponding Author
Ai-Jun Hou
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
E-mail: [email protected]Search for more papers by this authorJin-Qiu You
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorYun-Qi Jin
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorMeng-Yu Li
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorBo-Chao Zhang
Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China
Search for more papers by this authorXin-Yu Sun
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
Search for more papers by this authorChun-Yong Ding
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
Search for more papers by this authorJing-Ya Li
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 China
Search for more papers by this authorCorresponding Author
Ai-Jun Hou
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240 China
National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai, 200240 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
Hyperlanins A (1) and B (2), two highly rearranged polycyclic polyprenylated acylphloroglucinol (PPAP)-related meroterpenoids based on different new carbon skeletons, were isolated from Hypericum lancasteri. Compound 1 incorporates an unprecedented 5/6/7/5 ring system featuring a 3,13-dioxatetracyclo[9.2.1.12,5.01,8]pentadecane core. Compound 2 possesses a unique compact 6/6/5/6/6/5/6 ring system with a caged tetracyclo[6.2.1.13,8.05,11]dodecane motif. Their structures were established by spectroscopic data, X-ray diffraction, and computational approaches. Both compounds showed anti-inflammatory activity in vitro. Compounds 1 and 2 could decrease the lipopolysaccharide (LPS)-/nigericin-induced IL-1β release in THP-1 cells. Both compounds also showed inhibition in hypoxia-inducible factor-1α (HIF-1α) pathway luciferase reporter assay.
Supporting Information
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Appendix S1: Supporting Information |
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