Regular Article
Circular Dichroism Sensing of Chiral Compounds Using an Achiral Metal Complex as Probe
Burcin Irfanoglu,
Christian Wolf,
Burcin Irfanoglu
Department of Chemistry, Georgetown University, Washington, District of Columbia
Search for more papers by this authorChristian Wolf
Department of Chemistry, Georgetown University, Washington, District of Columbia
Search for more papers by this authorBurcin Irfanoglu,
Christian Wolf,
Burcin Irfanoglu
Department of Chemistry, Georgetown University, Washington, District of Columbia
Search for more papers by this authorChristian Wolf
Department of Chemistry, Georgetown University, Washington, District of Columbia
Search for more papers by this authorCorrespondence to: Christian Wolf, Georgetown University, Chemistry Department, 37th and O Streets NW, Washington DC, 20057. E-mail: [email protected]
ABSTRACT
Coordination of a chiral substrate to (meso-salen)cobalt(II) nitrate and subsequent oxidation generates a Co(III) complex exhibiting a strong chiroptical readout that is attributed to spontaneous substrate-to-ligand chirality imprinting. The characteristic circular dichroism (CD) response of the (salen)cobalt complex can be used for enantiomeric analysis of a variety of chiral substrates based on a simple CD measurement at low concentration and without additional purification steps. This chirality sensing approach has potential for high-throughput enantiomeric excess (ee) screening applications and minimizes solvent waste production. Chirality 26:379–384, 2014. © 2014 Wiley Periodicals, Inc.
Supporting Information
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