Experiments and Correlations of the Solubility of γ-DL-Methionine in Binary Solvent Mixtures
Peetikamol Kongsamai
Technopolis, Suranaree University of Technology, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Search for more papers by this authorChannakhone Phoumixay
Suranaree University of Technology, School of Chemical Engineering, Institute of Engineering, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Search for more papers by this authorCorresponding Author
Lek Wantha
Suranaree University of Technology, School of Chemical Engineering, Institute of Engineering, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Correspondence: Lek Wantha ([email protected]), School of Chemical Engineering, Institute of Engineering, Suranaree University of Technology, 111 University Avenue, Muang District, Nakhon Ratchasima, 30000, Thailand.Search for more papers by this authorPeetikamol Kongsamai
Technopolis, Suranaree University of Technology, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Search for more papers by this authorChannakhone Phoumixay
Suranaree University of Technology, School of Chemical Engineering, Institute of Engineering, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Search for more papers by this authorCorresponding Author
Lek Wantha
Suranaree University of Technology, School of Chemical Engineering, Institute of Engineering, 111 University Avenue, Muang District, 30000 Nakhon Ratchasima, Thailand
Correspondence: Lek Wantha ([email protected]), School of Chemical Engineering, Institute of Engineering, Suranaree University of Technology, 111 University Avenue, Muang District, Nakhon Ratchasima, 30000, Thailand.Search for more papers by this authorAbstract
Antisolvents increase the supersaturation in the crystallization process which can enhance the product yield. The effect of an antisolvent on the solubility of γ-DL-methionine (γ-DL-met) in aqueous solution was investigated. The solubility of γ-DL-met was measured with various binary solvent mixtures. It improved with higher temperature but decreased with increasing the antisolvent mass fraction. Acetone showed the highest efficiency to reduce the solubility. The solubilities were correlated with the van't Hoff-Jouyban-Acree model and the modified Apelblat-Jouyban-Acree model. Both models fitted to the experimental results with high accuracy. Enthalpy, entropy, and Gibbs free energy of dissolution were determined by van't Hoff analysis. The thermodynamic properties indicated that the dissolution process is endothermic and entropy-driven.
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