Correspondence: Muoi Tang ([email protected]), Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan.Search for more papers by this author

Chun-Hao Fang,

Chun-Hao Fang

National Taiwan University, Department of Chemical Engineering, Taipei, Taiwan

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Pei-Hua Chen,

Pei-Hua Chen

Taipei Medical University, Department of Orthopedics, Shuang Ho Hospital, Taipei, Taiwan

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Yan-Ping Chen,

Yan-Ping Chen

National Taiwan University, Department of Chemical Engineering, Taipei, Taiwan

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Muoi Tang,

Corresponding Author

Muoi Tang

[email protected]

Chinese Culture University, Department of Chemical and Materials Engineering, Taipei, Taiwan

Correspondence: Muoi Tang ([email protected]), Department of Chemical and Materials Engineering, Chinese Culture University, Taipei, Taiwan.Search for more papers by this author

First published: 08 January 2020

https://doi.org/10.1002/ceat.201900432

Citations: 12

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Abstract

The rapid expansion of supercritical solution (RESS) technology was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200 μm with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported.

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Volume43, Issue6

Special Issue:Industrial Crystallization – BIWIC 2019

June 2020

Pages 1186-1193

Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology

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Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology

Abstract

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Citing Literature

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