Research Article

Amoxicillin Extraction from Aqueous Solution by Emulsion Liquid Membranes Using Response Surface Methodology

Zahra Seifollahi

Iran University of Science & Technology (IUST), Faculty of Chemical Engineering, Farjam street, Narmak, 1684613114 Tehran, Iran

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Ahmad Rahbar-Kelishami,

Corresponding Author

Ahmad Rahbar-Kelishami

[email protected]

Iran University of Science & Technology (IUST), Faculty of Chemical Engineering, Farjam street, Narmak, 1684613114 Tehran, Iran

Correspondence: Ahmad Rahbar-Kelishami ([email protected]), Iran University of Science & Technology (IUST), Faculty of Chemical Engineering, Farjam street, Narmak, 1684613114 Tehran, Iran.Search for more papers by this author

Zahra Seifollahi,

Zahra Seifollahi

Iran University of Science & Technology (IUST), Faculty of Chemical Engineering, Farjam street, Narmak, 1684613114 Tehran, Iran

Search for more papers by this author

Ahmad Rahbar-Kelishami,

Corresponding Author

Ahmad Rahbar-Kelishami

[email protected]

Iran University of Science & Technology (IUST), Faculty of Chemical Engineering, Farjam street, Narmak, 1684613114 Tehran, Iran

First published: 18 October 2018

https://doi.org/10.1002/ceat.201800089

Citations: 22

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Abstract

The extraction of amoxicillin (AMX) from aqueous solutions by emulsion liquid membranes (ELMs) was investigated for the first time. The liquid membrane phase of the ELM consisted of Aliquat 336 as carrier, Span 80 as surfactant, n-hexane as diluent, and sodium chloride solution as internal phase. Response surface methodology (RSM) based on central composite design (CCD) was applied to evaluate and optimize the effects of several parameters such as carrier concentration, feed concentration, internal phase concentration, and treat ratio (volume ratio of the external phase to the emulsion phase). A polynomial model was fitted to predict the extraction yield of AMX. Under optimized conditions, the highest extraction yield of AMX was 99.8 %.

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Volume42, Issue1

January 2019

Pages 156-166

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Amoxicillin Extraction from Aqueous Solution by Emulsion Liquid Membranes Using Response Surface Methodology

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