Modeling Suspension Cultures of Microbial and Mammalian Cells with an Adaptable Six-Compartment Model
Simone Brüning
University of Applied Sciences Bremen, Institute for Environmental and Biotechnology, Neustadtswall 30, 28199 Bremen, Germany
Search for more papers by this authorInga Gerlach
University of Applied Sciences Bremen, Institute for Environmental and Biotechnology, Neustadtswall 30, 28199 Bremen, Germany
Linköping University, Division of Biotechnology/IFM, 58183 Linköping, Sweden
Search for more papers by this authorRalf Pörtner
Hamburg University of Technology, Institute for Bioprocess and Biosystems Engineering, Denickestraße 15, 21073 Hamburg, Germany
Search for more papers by this authorCarl-Fredrik Mandenius
Linköping University, Division of Biotechnology/IFM, 58183 Linköping, Sweden
Search for more papers by this authorCorresponding Author
Volker C. Hass
Furtwangen University, Faculty of Medical and Life Sciences, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany
Correspondence: Volker C. Hass ([email protected]), Furtwangen University, Faculty of Medical and Life Sciences, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany.Search for more papers by this authorSimone Brüning
University of Applied Sciences Bremen, Institute for Environmental and Biotechnology, Neustadtswall 30, 28199 Bremen, Germany
Search for more papers by this authorInga Gerlach
University of Applied Sciences Bremen, Institute for Environmental and Biotechnology, Neustadtswall 30, 28199 Bremen, Germany
Linköping University, Division of Biotechnology/IFM, 58183 Linköping, Sweden
Search for more papers by this authorRalf Pörtner
Hamburg University of Technology, Institute for Bioprocess and Biosystems Engineering, Denickestraße 15, 21073 Hamburg, Germany
Search for more papers by this authorCarl-Fredrik Mandenius
Linköping University, Division of Biotechnology/IFM, 58183 Linköping, Sweden
Search for more papers by this authorCorresponding Author
Volker C. Hass
Furtwangen University, Faculty of Medical and Life Sciences, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany
Correspondence: Volker C. Hass ([email protected]), Furtwangen University, Faculty of Medical and Life Sciences, Jakob-Kienzle-Straße 17, 78054 Villingen-Schwenningen, Germany.Search for more papers by this authorAbstract
Process models can be used for model-based control strategies, but model development is a time-consuming and laborious task. To reduce the modeling effort, a new structured compartment model was developed, which may easily be adapted to different cultivation processes. The proposed six-compartment model was used to describe the time courses of cultivations of bacteria, yeast, fungi, and mammalian cell lines, namely, Escherichia coli, Lactobacillus delbrueckii, Saccharomyces cerevisiae, Cyathus striatus, and a hybridoma mammalian cell line. The model can describe the time courses of important state variables and can be adapted to the cultivation processes by parameterization. This reduces the modeling effort for a new process significantly.
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