Crystallization of Piroxicam Solid Forms and the Effects of Additives
Guangpu Liu
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Search for more papers by this authorThomas B. Hansen
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Search for more papers by this authorCorresponding Author
Haiyan Qu
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.===Search for more papers by this authorMingshi Yang
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorJari P. Pajander
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorJukka Rantanen
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorLars P. Christensen
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Search for more papers by this authorGuangpu Liu
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Department of Pharmaceutics, School of Pharmaceutical Sciences, Shandong University, Jinan, China.
Search for more papers by this authorThomas B. Hansen
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Search for more papers by this authorCorresponding Author
Haiyan Qu
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.===Search for more papers by this authorMingshi Yang
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorJari P. Pajander
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorJukka Rantanen
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Search for more papers by this authorLars P. Christensen
Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Odense, Denmark.
Search for more papers by this authorAbstract
The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37 °C, form II is thermodynamically more stable than form I, while the relative stability of form II and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of form I are the ones with δT and δH parameters similar to those of piroxicam.
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