Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum
Chenggang Song
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorGang Ding
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorGang Wu
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJian Yang
State Key Laboratory of Dao-di Herbs Breeding Base, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 P. R. China
Search for more papers by this authorMingzhe Zhang
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorHaoyu Wang
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorDongsheng Wei
Institute of Wood Science, Department of Biology, University of Hamburg, Leuschnerstrasse 91, 21031 Hamburg, Germany
Search for more papers by this authorCorresponding Author
Jianchun Qin
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorCorresponding Author
Lanping Guo
State Key Laboratory of Dao-di Herbs Breeding Base, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 P. R. China
Search for more papers by this authorChenggang Song
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorGang Ding
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorGang Wu
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorJian Yang
State Key Laboratory of Dao-di Herbs Breeding Base, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 P. R. China
Search for more papers by this authorMingzhe Zhang
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorHaoyu Wang
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorDongsheng Wei
Institute of Wood Science, Department of Biology, University of Hamburg, Leuschnerstrasse 91, 21031 Hamburg, Germany
Search for more papers by this authorCorresponding Author
Jianchun Qin
College of Plant Science, Jilin University, Changchun, 130062 P. R. China
Search for more papers by this authorCorresponding Author
Lanping Guo
State Key Laboratory of Dao-di Herbs Breeding Base, National Resources Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700 P. R. China
Search for more papers by this authorAbstract
A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
Graphical Abstract
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