Organic cocrystals, particularly the evolution from binary to higher-order structures, have garnered considerable attention due to their tunable intermolecular interactions and unique material properties. Binary cocrystals, formed through π-π stacking, charge transfer, and hydrogen/halogen bonding, allow for precise control over molecular packing and enhanced optoelectronic properties. In contrast, higher-order cocrystals, incorporating three or more components, enable greater complexity and functional diversity. Strategies such as homologation via isostructural substitution, hierarchical intermolecular interactions, and long-range Synthon Aufbau Modules facilitate the synthesis of these advanced materials. The shift toward higher-order cocrystals paves the way for novel applications in fields such as deep learning for cocrystal prediction, drug design, organic solar cells, and NIR-II photothermal conversion. However, challenges related to molecular screening, ratio optimization, scalable synthesis, and long-term stability remain critical hurdles for the broader implementation of these materials in practical applications.