Drawing with Iron on a Gel Containing a Supramolecular Siderophore
Songjun Xiao
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorProf. Paul J. Paukstelis
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorDr. Richard D. Ash
Department of Geology, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorDr. Peter Y. Zavalij
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorCorresponding Author
Prof. Jeffery T. Davis
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorSongjun Xiao
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorProf. Paul J. Paukstelis
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorDr. Richard D. Ash
Department of Geology, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorDr. Peter Y. Zavalij
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorCorresponding Author
Prof. Jeffery T. Davis
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorGraphical Abstract
Soft matter, hard shell: pH-responsive hydrogels that can chelate Fe3+ were prepared from guanosine-5′-hydroxamic acid (HA). At high pH, the hydrogel binds thiazole orange, signaled by enhanced fluorescence. The HA units can also act as a supramolecular siderophore to form red complexes with Fe3+, which allowed the patterning of the hydrogel surface with FeCl3.
Abstract
Guanosine-5′-hydroxamic acid (3) forms hydrogels when mixed with guanosine (1) and KCl. The 5′-hydroxamic acid (HA) unit is pH-responsive and also chelates Fe3+. When gels are prepared under basic conditions, the 5′-HA groups are deprotonated and the anionic hydrogel binds cationic thiazole orange (TO), signaled by enhanced fluorescence. The HA nucleoside 3, when immobilized in the G-quartet gel, acts as a supramolecular siderophore to form red complexes with Fe3+. We patterned the hydrogel's surface with FeCl3, by hand and by using a 3D printer. Patterns form instantly, are visible by eye, and can be erased using vitamin C. This hydrogel, combining self-assembled G-quartet and siderophore–Fe3+ motifs, is strong, can be molded into different shapes, and is stable on the bench or under salt water.
Supporting Information
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