Functional Proteins from Short Peptides: Dayhoff's Hypothesis Turns 50
Dr. M. Luisa Romero Romero
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, 76100 Israel
Search for more papers by this authorAvigayel Rabin
Current address: Department of Biological Chemistry the Alexander Silberman Inst. of Life Sciences, the Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 91904 Israel
Search for more papers by this authorCorresponding Author
Prof. Dan S. Tawfik
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, 76100 Israel
Search for more papers by this authorDr. M. Luisa Romero Romero
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, 76100 Israel
Search for more papers by this authorAvigayel Rabin
Current address: Department of Biological Chemistry the Alexander Silberman Inst. of Life Sciences, the Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem, 91904 Israel
Search for more papers by this authorCorresponding Author
Prof. Dan S. Tawfik
Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, 76100 Israel
Search for more papers by this authorGraphical Abstract
First and foremost: Margaret Dayhoff's 1966 hypothesis on the origin of proteins is now an accepted model for the emergence of large, globular, functional proteins from short, simple peptides. However, the fundamental question of how the first protein(s) emerged still stands. The tools and hypotheses pioneered by Dayhoff, and the over 65 million protein sequences and 12 000 structures known today, enable those who follow in her footsteps to address this question.
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