Magnetically Triggered Dual Functional Nanoparticles for Resistance-Free Apoptotic Hyperthermia†
Dr. Dongwon Yoo
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorHeeyeong Jeong
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorSeung-Hyun Noh
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorDr. Jae-Hyun Lee
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorCorresponding Author
Prof. Jinwoo Cheon
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)===Search for more papers by this authorDr. Dongwon Yoo
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorHeeyeong Jeong
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorSeung-Hyun Noh
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorDr. Jae-Hyun Lee
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Search for more papers by this authorCorresponding Author
Prof. Jinwoo Cheon
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)
Department of Chemistry, Yonsei University, Seoul 120-749 (Korea)===Search for more papers by this authorThis work was financially supported by a grant from the Creative Research Initiative (grant number 2010-0018286).
Graphical Abstract
Overcoming resistance: Heat-treated cancer cells possess a protective mechanism for resistance and survival. Resistance-free apoptosis-inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).
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