Towards Structure Determination of Self-Assembled Peptides Using Dynamic Nuclear Polarization Enhanced Solid-State NMR Spectroscopy†
This work was supported by the French National Research Agency through the “programme blanc” (grant number ANR-12-BS08-0016-01) and the “programme Labex” (ARCANE project number ANR-11-LABX-003) and funding from the RTB. SEM images were taken at the PFNC platform at MINATEC (CEA Grenoble). P. A. Bayle is acknowledged for solution NMR measurements.
Graphical Abstract
Supra-sensitivity: Dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy was performed on self-assembled peptide nanotubes. This approach yields significant experimental time savings (about five orders of magnitude; see picture) and was used to exemplify the feasibility of supramolecular structural studies of organic nanoassemblies at an atomic scale using DNP-enhanced solid-state NMR spectroscopy.
