Stiffness-Transformable Nanoplatforms Responsive to the Tumor Microenvironment for Enhanced Tumor Therapeutic Efficacy
Jun Tao
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
These authors contributed to this work equally.
Search for more papers by this authorYing Tian
Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029 P. R. China
Department of Medical Imaging, Jinling Hospital, Nanjing, 210093 P. R. China
These authors contributed to this work equally.
Search for more papers by this authorDong Chen
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorWei Lu
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorKun Chen
Guangdong Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515 P. R. China
Search for more papers by this authorChaoli Xu
Department of Ultrasound Diagnostics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 P. R. China
Search for more papers by this authorDr. Lei Bao
School of Engineering, RMIT University, Melbourne, VIC 3000 Australia
Search for more papers by this authorProf. Bin Xue
Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093 P. R. China
Search for more papers by this authorTiankuo Wang
Shenzhen Institute of Advanced Technology Chinese Academy of Science, Shenzhen, 518020 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Zhaogang Teng
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Lianhui Wang
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorJun Tao
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
These authors contributed to this work equally.
Search for more papers by this authorYing Tian
Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029 P. R. China
Department of Medical Imaging, Jinling Hospital, Nanjing, 210093 P. R. China
These authors contributed to this work equally.
Search for more papers by this authorDong Chen
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorWei Lu
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorKun Chen
Guangdong Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515 P. R. China
Search for more papers by this authorChaoli Xu
Department of Ultrasound Diagnostics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029 P. R. China
Search for more papers by this authorDr. Lei Bao
School of Engineering, RMIT University, Melbourne, VIC 3000 Australia
Search for more papers by this authorProf. Bin Xue
Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210093 P. R. China
Search for more papers by this authorTiankuo Wang
Shenzhen Institute of Advanced Technology Chinese Academy of Science, Shenzhen, 518020 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Zhaogang Teng
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Lianhui Wang
Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing, 210023 P. R. China
Search for more papers by this authorAbstract
Herein, we report, for the first time, a unique stiffness-transformable manganese oxide hybridized mesoporous organosilica nanoplatform (MMON) for enhancing tumor therapeutic efficacy. The prepared MMONs had a quasi-spherical morphology and were completely transformed into soft bowl-like nanocapsules in the simulated tumor microenvironment through the breakage of Mn−O bonds, which decreased their Young's modulus from 165.7 to 84.5 MPa. Due to their unique stiffness transformation properties, the MMONs had reduced macrophage internalization, improved tumor cell uptake, and enhanced penetration of multicellular spheroids. In addition, in vivo experiments showed that the MMONs displayed a 3.79- and 2.90-fold decrease in non-specific liver distribution and a 2.87- and 1.83-fold increase in tumor accumulation compared to their soft and stiff counterparts, respectively. Furthermore, chlorin e6 (Ce6) modified MMONs had significantly improved photodynamic therapeutic effect.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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