Yttrium-86 Is a Positron Emitting Surrogate of Gadolinium for Noninvasive Quantification of Whole-Body Distribution of Gadolinium-Based Contrast Agents
Dr. Mariane Le Fur
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorNicholas J. Rotile
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorCarlos Correcher
Bruker BioSpin, Preclinical Imaging Division, Eduardo Primo Yúfera 3, 46013 Valencia, Spain
Search for more papers by this authorDr. Veronica Clavijo Jordan
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorAlana W. Ross
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorProf. Ciprian Catana
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorCorresponding Author
Prof. Peter Caravan
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorDr. Mariane Le Fur
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorNicholas J. Rotile
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorCarlos Correcher
Bruker BioSpin, Preclinical Imaging Division, Eduardo Primo Yúfera 3, 46013 Valencia, Spain
Search for more papers by this authorDr. Veronica Clavijo Jordan
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorAlana W. Ross
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorProf. Ciprian Catana
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorCorresponding Author
Prof. Peter Caravan
The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, MA, 02129 USA
Search for more papers by this authorAbstract
Gadolinium-based contrast agents (GBCAs) are used to provide diagnostic information in clinical magnetic resonance (MR) examinations. Gadolinium (Gd) has been detected in the brain, bone and skin of patients, months and years following GBCA administration, raising concerns about long term toxicity. Despite increased scrutiny, the concentration, chemical form and fate of the retained gadolinium species remain unknown. Importantly, the whole body biodistribution and organ clearance of GBCAs is poorly understood in humans. Gadolinium lacks suitable isotopes for nuclear imaging. We demonstrate that the yttrium-86 isotope can be used as a gadolinium surrogate. We show that Gd and their analogous Y complexes have similar properties both in solution and in vivo, and that yttrium-86 PET can be used to track the biodistribution of GBCAs over a two-day period.
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References
- 1J. Wahsner, E. M. Gale, A. Rodríguez-Rodríguez, P. Caravan, Chem. Rev. 2019, 119, 957–1057.
- 2R. J. McDonald, D. Levine, J. Weinreb, E. Kanal, M. S. Davenport, J. H. Ellis, P. M. Jacobs, R. E. Lenkinski, K. R. Maravilla, M. R. Prince, et al., Radiology 2018, 289, 517–534.
- 3T. Grobner, Nephrol. Dial. Transplant. 2006, 21, 1104–1108.
- 4P. Marckmann, L. Skov, K. Rossen, A. Dupont, M. B. Damholt, J. G. Heaf, H. S. Thomsen, J. Am. Soc. Nephrol. 2006, 17, 2359–2362.
- 5W. A. High, R. A. Ayers, J. Chandler, G. Zito, S. E. Cowper, J. Am. Acad. Dermatol. 2007, 56, 21–26.
- 6A. S. Boyd, J. A. Zic, J. L. Abraham, J. Am. Acad. Dermatol. 2007, 56, 27–30.
- 7T. Kanda, K. Ishii, H. Kawaguchi, K. Kitajima, D. Takenaka, Radiology 2014, 270, 834–841.
- 8R. J. McDonald, J. S. McDonald, D. F. Kallmes, M. E. Jentoft, D. L. Murray, K. R. Thielen, E. E. Williamson, L. J. Eckel, Radiology 2015, 275, 772–782.
- 9T. Kanda, T. Fukusato, M. Matsuda, K. Toyoda, H. Oba, T. Haruyama, K. Kitajima, S. Furui, Radiology 2015, 276, 228–232.
- 10W. A. Gibby, K. A. Gibby, W. A. Gibby, Invest. Radiol. 2004, 39, 138–142.
- 11European Medicines Agency, https://www.ema.europa.eu/documents/press-release/emas-final-opinion-confirms-restrictions-use-linear-gadolinium-agents-body-scans_en.pdf 2017, EMA/457616/2017.
- 12M. Le Fur, P. Caravan, Metallomics 2019, 11, 240–254.
- 13J. E. Huckle, E. Altun, M. Jay, R. C. Semelka, Invest. Radiol. 2016, 51, 236–240.
- 14K. Kumar, C. A. Chang, L. C. Francesconi, D. D. Dischino, M. F. Malley, J. Z. Gougoutas, M. F. Tweedle, Inorg. Chem. 1994, 33, 3567–3575.
- 15K. P. Pulukkody, T. J. Norman, D. Parker, L. Roylet, C. J. Broan, J. Chem. Soc. Perkin Trans. 2 1993, 0, 605–620.
- 16M. Le Fur, M. Beyler, E. Molnár, O. Fougère, D. Esteban-Gómez, G. Tircsó, C. Platas-Iglesias, N. Lepareur, O. Rousseaux, R. Tripier, Inorg. Chem. 2018, 57, 2051–2063.
- 17J. Moreau, E. Guillon, J. C. Pierrard, J. Rimbault, M. Port, M. Aplincourt, Chem. Eur. J. 2004, 10, 5218–5232.
- 18L. Sarka, L. Burai, E. Brücher, Chem. Eur. J. 2000, 6, 719–724.
10.1002/(SICI)1521-3765(20000218)6:4<719::AID-CHEM719>3.0.CO;2-2 CAS PubMed Web of Science® Google Scholar
- 19P. Robert, T. Frenzel, C. Factor, G. Jost, M. Rasschaert, G. Schuetz, N. Fretellier, J. Boyken, J.-M. Idée, H. Pietsch, Invest. Radiol. 2018, 53, 499–517.
- 20E. Di Gregorio, G. Ferrauto, C. Furlan, S. Lanzardo, R. Nuzzi, E. Gianolio, S. Aime, Invest. Radiol. 2018, 53, 167–172.
- 21M. F. Tweedle, P. Wedeking, K. Kumar, Invest. Radiol. 1995, 30, 372–380.
- 22P. Wedeking, M. Tweedle, Nucl. Med. Biol. 1988, 15, 395–402.
- 23M. Rohrer, H. Bauer, J. Mintorovitch, M. Requardt, H.-J. Weinmann, Invest. Radiol. 2005, 40, 715–724.
- 24E. Terreno, S. G. Crich, S. Belfiore, L. Biancone, C. Cabella, G. Esposito, A. D. Manazza, S. Aime, Magn. Reson. Med. 2006, 55, 491–497.
- 25P. E. N. Braad, S. B. Hansen, H. Thisgaard, P. F. Høilund-Carlsen, Phys. Med. Biol. 2015, 60, 3479–3497.
- 26R. J. Mcdonald, J. S. Mcdonald, D. Schroeder, M. E. Jentoft, D. L. Murray, L. J. Eckel, D. F. Kallmes, Radiology 2017, 285, 536–545.
- 27S. Bussi, A. Coppo, C. Botteron, V. Fraimbault, A. Fanizzi, E. De Laurentiis, S. Colombo Serra, M. A. Kirchin, F. Tedoldi, F. Maisano, J. Magn. Reson. Imaging 2018, 47, 746–752.
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