A Telomerase-Responsive DNA Icosahedron for Precise Delivery of Platinum Nanodrugs to Cisplatin-Resistant Cancer
Yi Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
These authors contributed equally to this work.
Search for more papers by this authorZhaohui Wang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
These authors contributed equally to this work.
Search for more papers by this authorYuxuan Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhihao Han
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorMin Zhang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Haiyan Chen
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Yueqing Gu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorYi Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
These authors contributed equally to this work.
Search for more papers by this authorZhaohui Wang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
These authors contributed equally to this work.
Search for more papers by this authorYuxuan Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhihao Han
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorMin Zhang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Haiyan Chen
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Yueqing Gu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorAbstract
A telomerase-responsive DNA icosahedron was designed to precisely release caged platinum nanodrugs into cisplatin-resistance tumor cells for effective therapy. This DNA icosahedron was constructed from two pyramidal DNA cages connected with telomerase primers and telomeric repeats, and platinum nanodrugs were then encapsulated into the DNA structure. In the presence of telomerase, the primers are extended, leading to inner-chain substitution of the DNA icosahedron and subsequent release of the caged nanodrugs. This DNA icosahedron can precisely release caged nanodrugs in response to telomerase in tumor cells, giving enhanced anticancer efficacy in drug-resistant carcinoma and with reduced toxicity to normal tissues. We speculate that this precisely designed, well controlled DNA cage could be generalized to diverse anticancer drugs.
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