Interactions of Renal-Clearable Gold Nanoparticles with Tumor Microenvironments: Vasculature and Acidity Effects
Prof. Dr. Mengxiao Yu
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorDr. Chen Zhou
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorProf. Dr. Li Liu
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390 USA
Search for more papers by this authorDr. Shanrong Zhang
Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Search for more papers by this authorDr. Shasha Sun
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorJulia D. Hankins
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Xiankai Sun
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Jie Zheng
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorProf. Dr. Mengxiao Yu
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorDr. Chen Zhou
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorProf. Dr. Li Liu
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390 USA
Search for more papers by this authorDr. Shanrong Zhang
Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Search for more papers by this authorDr. Shasha Sun
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorJulia D. Hankins
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Xiankai Sun
Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390 USA
Search for more papers by this authorCorresponding Author
Prof. Dr. Jie Zheng
Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX, 75080 USA
Search for more papers by this authorAbstract
The success of nanomedicines in the clinic depends on our comprehensive understanding of nano–bio interactions in tumor microenvironments, which are characterized by dense leaky microvasculature and acidic extracellular pH (pHe) values. Herein, we investigated the accumulation of ultrasmall renal-clearable gold NPs (AuNPs) with and without acidity targeting in xenograft mouse models of two prostate cancer types, PC-3 and LNCaP, with distinct microenvironments. Our results show that both sets of AuNPs could easily penetrate into the tumors but their uptake and retention were mainly dictated by the tumor microvasculature and the enhanced permeability and retention effect over the entire targeting process. On the other hand, increased tumor acidity indeed enhanced the uptake of AuNPs with acidity targeting, but only for a limited period of time. By making use of simple surface chemistry, these two effects can be synchronized in time for high tumor targeting, opening new possibilities to further improve the targeting efficiencies of nanomedicines.
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