Synthesis of Aryldifluoroamides by Copper-Catalyzed Cross-Coupling
Sophie I. Arlow
Department of Chemistry, University of California, Berkeley, CA, 94720 USA
Search for more papers by this authorCorresponding Author
Prof. John F. Hartwig
Department of Chemistry, University of California, Berkeley, CA, 94720 USA
Search for more papers by this authorSophie I. Arlow
Department of Chemistry, University of California, Berkeley, CA, 94720 USA
Search for more papers by this authorCorresponding Author
Prof. John F. Hartwig
Department of Chemistry, University of California, Berkeley, CA, 94720 USA
Search for more papers by this authorAbstract
A copper-catalyzed coupling of aryl, heteroaryl, and vinyl iodides with α-silyldifluoroamides is reported. The reaction forms α,α-difluoro-α-aryl amides from electron-rich, electron-poor, and sterically hindered aryl iodides in high yield and tolerates a variety of functional groups. The aryldifluoroamide products can be transformed further to provide access to a diverse array of difluoroalkylarenes, including compounds of potential biological interest.
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