Zuschrift
General Method for the Synthesis of Salicylic Acids from Phenols through Palladium-Catalyzed Silanol-Directed CH Carboxylation†
Yang Wang,
Prof. Dr. Vladimir Gevorgyan,
Yang Wang
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup
Search for more papers by this authorCorresponding Author
Prof. Dr. Vladimir Gevorgyan
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroupSearch for more papers by this authorYang Wang,
Prof. Dr. Vladimir Gevorgyan,
Yang Wang
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup
Search for more papers by this authorCorresponding Author
Prof. Dr. Vladimir Gevorgyan
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroup
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Room 4500, Chicago, IL 60607 (USA) http://www.chem.uic.edu/vggroupSearch for more papers by this author†
We gratefully acknowledge the National Institutes of Health (GM-64444) and National Science Foundation (CHE-1362541) for financial support. We also thank Marvin Parasram for helpful discussions during preparation of the manuscript.
Abstract
A silanol-directed, palladium-catalyzed CH carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o′-disubstituted phenolic compound through two sequential CH functionalization processes.
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