Multisite Organic–Inorganic Hybrid Catalysts for the Direct Sustainable Synthesis of GABAergic Drugs†
Dr. Antonio Leyva-Pérez
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Search for more papers by this authorCorresponding Author
Dr. Pilar García-García
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/Search for more papers by this authorCorresponding Author
Prof. Dr. Avelino Corma
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/Search for more papers by this authorDr. Antonio Leyva-Pérez
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Search for more papers by this authorCorresponding Author
Dr. Pilar García-García
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/Search for more papers by this authorCorresponding Author
Prof. Dr. Avelino Corma
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/
Instituto de Tecnología Química, UPV-CSIC, Universidad Politécnica de Valencia, Avenida de los Naranjos s/n, 46022 Valencia (Spain) http://itq.upv-csic.es/en/Search for more papers by this authorThis work was supported by the Spanish Government (Consolider Ingenio 2010-MULTICAT (CSD2009-00050) and MAT2011-29020-C02-01). P.G.-G. is grateful for a JAE-DOC contract from CSIC cofunded by the ESF. A.L.P. thanks ITQ for a contract. The Severo Ochoa program is thankfully acknowledged.
Abstract
Multisite organic–inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation.
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