A Robust Nickel Catalyst for Cyanomethylation of Aldehydes: Activation of Acetonitrile under Base-Free Conditions†
Dr. Sumit Chakraborty
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorYogi J. Patel
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorDr. Jeanette A. Krause
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorCorresponding Author
Prof. Hairong Guan
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.htmlSearch for more papers by this authorDr. Sumit Chakraborty
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorYogi J. Patel
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorDr. Jeanette A. Krause
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Search for more papers by this authorCorresponding Author
Prof. Hairong Guan
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.html
Department of Chemistry, University of Cincinnati, P. O. Box 210172, Cincinnati, OH 45221-0172 (USA) http://homepages.uc.edu/∼guanhg/index.htmlSearch for more papers by this authorWe thank the U.S. National Science Foundation (CHE-0952083) for support of this research. X-Ray data were collected on a Bruker SMART6000 diffractometer which was purchased with funding provided by an NSF-MRI grant (CHE-0215950).
Graphical Abstract
Wer braucht schon Basen? Der Nickel-Cyanmethyl-Komplex 1 katalysiert die Kupplung von Aldehyden mit Acetonitril bei Raumtemperatur ohne Basenzusatz. Das langlebige und bemerkenswert effiziente Katalysatorsystem erreicht hohe Umsatzzahlen (TON) und -frequenzen (TOF), und die milden Reaktionsbedingungen ermöglichen den Einsatz auch basenempfindlicher Aldehyde.
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