A Cationic High-Valent Cp*CoIII Complex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed CH Bond Activation†
Tatsuhiko Yoshino
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Search for more papers by this authorHideya Ikemoto
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Search for more papers by this authorCorresponding Author
Dr. Shigeki Matsunaga
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Japan Science and Technology Agency, ACT-C, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html===Search for more papers by this authorCorresponding Author
Prof. Dr. Motomu Kanai
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Japan Science and Technology Agency, ERATO, Kanai Life Science Catalysis Project, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html===Search for more papers by this authorTatsuhiko Yoshino
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Search for more papers by this authorHideya Ikemoto
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Search for more papers by this authorCorresponding Author
Dr. Shigeki Matsunaga
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Japan Science and Technology Agency, ACT-C, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html===Search for more papers by this authorCorresponding Author
Prof. Dr. Motomu Kanai
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html
Japan Science and Technology Agency, ERATO, Kanai Life Science Catalysis Project, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan) http://www.f.u-tokyo.ac.jp/∼kanai/e_index.html===Search for more papers by this authorThis research was supported in part by the ERATO program of JST (M.K.), a Grant-in-Aid for Scientific Research on Innovative Areas (“Molecular Activation Directed toward Straightforward Synthesis”) from MEXT (S.M.), the ACT-C program of JST (S.M.), and the Naito Foundation. T.Y. thanks the JSPS for fellowships. Cp*=pentamethylcyclopentadienyl.
Graphical Abstract
Aktiv ohne Aktivierung: In einem preiswerten und atomökonomischen Ansatz der C-H-Funktionalisierung wird ein kationischer Cobalt(III)-Komplex verwendet, um nucleophile metallorganische Spezies in situ ohne Zusatz aktivierender Reagentien herzustellen (siehe Schema). Aryl-C-H-Bindungen addieren effizient an polare Elektrophile, einschließlich α,β-ungesättigter N-Acylpyrrole als β-substituierte Ester- und Amid-Surrogate.
Supporting Information
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