Fluoreszenzsonden zum Nachweis von Schwefelwasserstoff in biologischen Systemen†
Weimin Xuan
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chunquan Sheng
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Chunquan Sheng, Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Wei Wang, Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorYanting Cao
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorWenhan He
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Wei Wang
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
School of Pharmacy, East China University of Science & Technology, 130 Mei-Long Road, Shanghai 200237 (China)
Chunquan Sheng, Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Wei Wang, Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorWeimin Xuan
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chunquan Sheng
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Chunquan Sheng, Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Wei Wang, Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorYanting Cao
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorWenhan He
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Wei Wang
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
School of Pharmacy, East China University of Science & Technology, 130 Mei-Long Road, Shanghai 200237 (China)
Chunquan Sheng, Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
Wei Wang, Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
Search for more papers by this authorWir danken der National Science Foundation (CHE-1057569), dem China 111 Project (Grant B07023) und der East China University of Science & Technology für die finanzielle Unterstützung unserer Forschungsarbeiten.
Graphical Abstract
H2S ans Licht gebracht: Drei hochempfindliche und hochselektive Fluoreszenzsonden für den Nachweis von H2S wurden entwickelt. Zwei dieser Sonden weisen H2S durch Reduktion einer Azid- zu einer Aminogruppe nach, wodurch ein fluoreszierendes Molekül entsteht. Die dritte Methode setzt H2S als Nukleophil in einer Demaskierungsreaktion von Fluorescein ein.
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