Zuschrift

Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus^†

Dr. Xudong Qu

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

Search for more papers by this author

Dr. Chun Lei,

Dr. Chun Lei

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

Search for more papers by this author

Prof. Dr. Wen Liu,

Corresponding Author

Prof. Dr. Wen Liu

[email protected]

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)Search for more papers by this author

Dr. Xudong Qu,

Dr. Xudong Qu

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

Search for more papers by this author

Dr. Chun Lei,

Dr. Chun Lei

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

Search for more papers by this author

Prof. Dr. Wen Liu,

Corresponding Author

Prof. Dr. Wen Liu

[email protected]

State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Rd., Shanghai 200032 (China)

First published: 21 September 2011

https://doi.org/10.1002/ange.201103085

Citations: 2

^†

This work was supported in part by grants from NNSF of China (30900021, 20902102, 20921091, and 20832009), SRF for 39th ROCS-SEM, “973 program” (2010CB833200, and 2012CB721100), CAS (KJCX2-YW-201), and STCSM (09QH1402700). We thank Dr. M. J. Smanski from the University of Wisconsin–Madison for discussion and critical reading.

Share a link

Email
Wechat
Bluesky

Graphical Abstract

Alternativer Ansatz: Biosynthesewege und die Produktion dazugehöriger Naturstoffe wurden auf Transkriptionsebene in Streptomyces flaveolus mit einer Transkriptom-Screening-Strategie untersucht (siehe Bild). Der Ansatz ergänzt jüngste Fortschritte in der Genomanalyse und könnte die Entdeckung von Naturstoffen aus Bakterienstämmen, deren Genom noch nicht sequenziert wurde, erleichtern.

Supporting Information

References

1D. J. Newman, G. M. Cragg in Natural Product Chemistry for Drug Discovery (Eds.: ), Royal Society of Chemistry, Cambridge, 2010, pp. 3–27.
Google Scholar
2M. Nett, H. Ikeda, B. S. Moore, Nat. Prod. Rep. 2009, 26, 1362–1384.
10.1039/b817069j
CAS PubMed Web of Science® Google Scholar
3C. Corre, G. L. Challis, Nat. Prod. Rep. 2009, 26, 977–986.
10.1039/b713024b
CAS PubMed Web of Science® Google Scholar
4
4aL. Laureti, L. Song, S. Huang, C. Corre, P. Leblond, G. L. Challis, B. Aigle, Proc. Natl. Acad. Sci. USA 2011, 108, 6258–6263;
10.1073/pnas.1019077108
CAS PubMed Web of Science® Google Scholar
4bS. Bergmann, J. Schumann, K. Scherlach, C. Lange, A. A. Brakhage, C. Hertweck, Nat. Chem. Biol. 2007, 3, 213–217;
10.1038/nchembio869
CAS PubMed Web of Science® Google Scholar
4cC. Wang, D. E. Cane, J. Am. Chem. Soc. 2008, 130, 8908–8909.
10.1021/ja803639g
CAS PubMed Web of Science® Google Scholar
5aS. B. Bumpus, B. S. Evans, P. M. Thomas, I. Ntai, N. L. Kelleher, Nat. Biotechnol. 2009, 27, 951–956;
10.1038/nbt.1565
CAS PubMed Web of Science® Google Scholar
5bB. S. Evans, I. Ntai, Y. Chen, A. J. Robinson, N. L. Kelleher, J. Am. Chem. Soc. 2011, 133, 7316–7319.
10.1021/ja2015795
CAS PubMed Web of Science® Google Scholar
6C. I. Keeling, S. Weisshaar, S. G. Ralph, S. Jancsik, B. Hamberger, H. K. Dullat, J. Bohlmann, BMC Plant Biol. 2011, 11, 43.
10.1186/1471-2229-11-43
CAS PubMed Web of Science® Google Scholar
7E. Zazopoulos, K. Huang, A. Staffa, W. Liu, B. O. Bachmann, K. Nonaka, J. Ahlert, J. S. Thorson, B. Shen, C. M. Farnet, Nat. Biotechnol. 2003, 21, 187–190.
10.1038/nbt784
CAS PubMed Web of Science® Google Scholar
8J. W. Bok, Y.-M. Chiang, E. Szewczyk, Y. Reyes-Dominguez, A. D. Davidson, J. F. Sanchez, H.-C. Lo, K. Watanabe, J. Strauss, B. R. Oakley, C. C. C. Wang, N. P. Keller, Nat. Chem. Biol. 2009, 5, 462–464.
10.1038/nchembio.177
CAS PubMed Web of Science® Google Scholar
9K. M. Fisch, C. Gurgui, N. Heycke, S. A. van der Sar, S. A. Anderson, V. L. Webb, S. Taudien, M. Platzer, B. K. Rubio, S. J. Robinson, P. Crews, J. Piel, Nat. Chem. Biol. 2009, 5, 494–501.
10.1038/nchembio.176
CAS PubMed Web of Science® Google Scholar
10T. Hosaka, M. Ohnishi-Kameyama, H. Muramatsu, K. Murakami, Y. Tsurumi, S. Kodani, M. Yoshida, A. Fujie, K. Ochi, Nat. Biotechnol. 2009, 27, 462–464.
10.1038/nbt.1538
CAS PubMed Web of Science® Google Scholar
11X. Qu, N. Jiang, F. Xu, L. Shao, G. Tang, B. Wilkinson, W. Liu, Mol. BioSyst. 2011, 7, 852–861.
10.1039/C0MB00234H
CAS PubMed Web of Science® Google Scholar
12aJ. Staunton, K. J. Weissman, Nat. Prod. Rep. 2001, 18, 380–416;
10.1039/a909079g
CAS PubMed Web of Science® Google Scholar
12bM. A. Marahiel, T. Stachelhaus, H. D. Mootz, Chem. Rev. 1997, 97, 2651–2674;
10.1021/cr960029e
CAS PubMed Web of Science® Google Scholar
12cR. Liao, L. Duan, C. Lei, H. Pan, Y. Ding, Q. Zhang, D. Chen, B. Shen, Y. Yu, W. Liu, Chem. Biol. 2009, 16, 141–147;
10.1016/j.chembiol.2009.01.007
CAS PubMed Web of Science® Google Scholar
12dH. Decker, S. Gaisser, S. Pelzer, P. Schneider, L. Westrich, W. Wohlleben, A. Bechthold, FEMS Microbiol. Lett. 1996, 141, 195–201;
10.1111/j.1574-6968.1996.tb08384.x
CAS PubMed Web of Science® Google Scholar
12eA. Hornung, M. Bertazzo, A. Dziarnowski, K. Schneider, K. Welzel, S. Wohlert, M. Holzenkämpfer, G. J. Nicholson, A. Bechthold, R. D. Süssmuth, A. Vente, S. Pelzer, ChemBioChem 2007, 8, 757–766.
10.1002/cbic.200600375
CAS PubMed Web of Science® Google Scholar
13J. J. Sanglier, V. Quesniaux, T. Fehr, H. Hofmann, M. Mahnke, K. Memmert, W. Schuler, G. Zenke, L. Gschwind, C. Maurer, W. Schilling, J. Antibiot. 1999, 52, 466–473.
10.7164/antibiotics.52.466
CAS PubMed Web of Science® Google Scholar
14
14aS. Funayama, K. Okada, K. Iwasaki, K. Komiyama, I. Umezawa, J. Antibiot. 1985, 38, 1677–1683;
10.7164/antibiotics.38.1677
CAS PubMed Web of Science® Google Scholar
14bM. Damberg, P. Russ, A. Zeeck, Tetrahedron Lett. 1982, 23, 59–62;
10.1016/S0040-4039(00)97531-2
CAS Web of Science® Google Scholar
14cN. Hosokawa, H. Naganawa, H. Inuma, M. Hamada, T. Takeuchi, T. Kanbe, M. Hori, J. Antibiot. 1995, 48, 471–478.
10.7164/antibiotics.48.471
CAS PubMed Web of Science® Google Scholar
15T. A. Cropp, D. J. Wilson, K. A. Reynolds, Nat. Biotechnol. 2000, 18, 980–983.
10.1038/79479
CAS PubMed Web of Science® Google Scholar
16S. Chen, D. v. Bamberg, V. Hale, M. Breuer, B. Hardt, R. Muller, H. G. Floss, K. A. Reynolds, E. Leistner, Eur. J. Biochem. 1999, 261, 98–107.
10.1046/j.1432-1327.1999.00244.x
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume123, Issue41

October 4, 2011

Pages 9825-9828

This is the

German version

of Angewandte Chemie.

Note for articles published since 1962:

Do not cite this version alone.

Take me to the International Edition version with citable page numbers, DOI, and citation export.

We apologize for the inconvenience.

Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus^†

Graphical Abstract

Supporting Information

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus†

Graphical Abstract

Supporting Information

References

Citing Literature

References

Related

Information

Transcriptome Mining of Active Biosynthetic Pathways and Their Associated Products in Streptomyces flaveolus^†