Alternative Pathways for Heck Intermediates: Palladium-Catalyzed Oxyarylation of Homoallylic Alcohols†
Corresponding Author
Dr. Chen Zhu
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455Search for more papers by this authorProf. Dr. John R. Falck
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
Search for more papers by this authorCorresponding Author
Dr. Chen Zhu
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455Search for more papers by this authorProf. Dr. John R. Falck
Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038 (USA), Fax: (+1) 214-648-6455
Search for more papers by this authorWe thank the NIH (GM31278) and the Robert A. Welch Foundation (GL625910) for financial support.
Graphical Abstract
Die Koordination der Hydroxygruppe an den Katalysator ist einer der Hauptgründe für die guten Ausbeuten und Regioselektivitäten in der oxidativen Heck-Arylierung von Homoallylalkoholen (siehe Schema). Ferner lässt sich das Heck-Intermediat durch eine intramolekular palladiumkatalysierte Olefin-Oxycyclisierung abfangen, die den Weg zu α-Aryltetrahydrofuranen mit hoch funktionalisierten Molekülgerüsten ebnet.
Supporting Information
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