Total Chemical Synthesis of Di-ubiquitin Chains†
Dr. K. S. Ajish Kumar
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
These authors contributed equally.
Search for more papers by this authorLiat Spasser
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
These authors contributed equally.
Search for more papers by this authorLesly A. Erlich
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Search for more papers by this authorDr. Sudhir N. Bavikar
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Search for more papers by this authorCorresponding Author
Dr. Ashraf Brik
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrikSearch for more papers by this authorDr. K. S. Ajish Kumar
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
These authors contributed equally.
Search for more papers by this authorLiat Spasser
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
These authors contributed equally.
Search for more papers by this authorLesly A. Erlich
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Search for more papers by this authorDr. Sudhir N. Bavikar
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Search for more papers by this authorCorresponding Author
Dr. Ashraf Brik
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrik
Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva 84105 (Israel), Fax: (+972) 8-647-2943 http://www.bgu.ac.il/∼abrikSearch for more papers by this authorThis work was supported by the Edmond J. Safra Foundation.
Graphical Abstract
Wie man Ketten bildet zeigt ein allgemeiner und effektiver Weg zur chemischen Totalsynthese aller Diubiquitin-Ketten (siehe Bild). Das Verhalten der synthetisierten Ketten in Gegenwart von Isopeptidase T, einem Enzym, das die meisten nichtverankerten Polyubiquitine in vivo zerlegt, wurde untersucht.
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