Catalytic Asymmetric Bromoamination of Chalcones: Highly Efficient Synthesis of Chiral α-Bromo-β-Amino Ketone Derivatives†
Yunfei Cai
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorXiaohua Liu Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorYonghai Hui
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorJun Jiang
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorWentao Wang
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorWeiliang Chen
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorLili Lin Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorXiaoming Feng Prof. Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorYunfei Cai
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorXiaohua Liu Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorYonghai Hui
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorJun Jiang
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorWentao Wang
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorWeiliang Chen
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorLili Lin Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorXiaoming Feng Prof. Dr.
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (China), Fax: (+86) 28-8541-8249
Search for more papers by this authorWe appreciate the financial support from the National Natural Science Foundation of China (Nos. 20732003 and 20872097), the PCSIRT (No. IRT0846), and the National Basic Research Program of China (973 Program; No. 2010CB833300). We also thank Sichuan University Analytical & Testing Center for NMR analysis.
Graphical Abstract
Sparsam mit dem Katalysator: In der unter milden Bedingungen über eine Bromonium-Zwischenstufe verlaufenden Titelreaktion wurden mit 0.05 Mol-% eines C2-symmetrischen N,N′-Dioxid-Scandium(III)-Komplexes hervorragende Resultate erzielt (siehe Schema).
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