What is Amphidinolide V? Report on a Likely Conquest†
Alois Fürstner Prof.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorOleg Larionov Dr.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorSusanne Flügge Dipl.-Chem.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorAlois Fürstner Prof.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorOleg Larionov Dr.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorSusanne Flügge Dipl.-Chem.
Max-Planck-Institut für Kohlenforschung, 45470 Mülheim an der Ruhr, Germany, Fax: (+49) 208-306-2994
Search for more papers by this authorGenerous financial support from the MPG and the Fonds der Chemischen Industrie (Kekulé fellowship to S.F.) is gratefully acknowledged. We thank Prof. J.-I. Kobayashi for an exchange of information.
Graphical Abstract
Die beeindruckende Leistungsfähigkeit der Metathese zeigt sich in der Synthese der für den cytotoxischen Naturstoff Amphidinolid V vorgeschlagenen Struktur sowie aller anderen Stereomere mit einer trans-Epoxideinheit. Aus dem erhaltenen umfangreichen Datensatz lässt sich folgern, dass die 8S,9R,10R,13S-konfigurierte Verbindung 1 höchstwahrscheinlich Amphidinolid V ist, auch wenn ein 1H-NMR-Signal vom beschriebenen Wert abweicht.
Supporting Information
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