Mimicking Fructose and Rhamnulose Aldolases: Organocatalytic syn-Aldol Reactions with Unprotected Dihydroxyacetone†
S. S. V. Ramasastry Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorKlaus Albertshofer
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorNaoto Utsumi Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorFujie Tanaka Prof. Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorCarlos F. Barbas III Prof. Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorS. S. V. Ramasastry Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorKlaus Albertshofer
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorNaoto Utsumi Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorFujie Tanaka Prof. Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorCarlos F. Barbas III Prof. Dr.
The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA, Fax: (+1) 858-784-2583
Search for more papers by this authorThis study was supported in part by The Skaggs Institute for Chemical Biology.
Graphical Abstract
Nachahmende Amine: Aminosäuren mit primären Aminfunktionen katalysieren syn-selektive asymmetrische Aldolreaktionen zwischen nichtgeschütztem Dihydroxyaceton und mehreren aromatischen und aliphatischen Aldehyden (siehe Schema). Die vorgestellte Strategie ahmt die Wirkung der L-Rhamnulose-1-phosphat- und D-Fructose-1,6-Diphosphat-Aldolasen nach.
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