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A Pocket-Sized Convective PCR Thermocycler^†

Nitin Agrawal Dr.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA, Fax: (+1) 979-458-1002

Present address: Center for Engineering in Medicine/Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital and Harvard Medical School, Boston, MA 02114, USA

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Yassin A. Hassan Prof.,

Yassin A. Hassan Prof.

Department of Nuclear Engineering, Texas A&M University, College Station, TX 77843, USA

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Victor M. Ugaz Prof.,

Victor M. Ugaz Prof.

[email protected]

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA, Fax: (+1) 979-458-1002

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Nitin Agrawal Dr.,

Nitin Agrawal Dr.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA, Fax: (+1) 979-458-1002

Present address: Center for Engineering in Medicine/Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital and Harvard Medical School, Boston, MA 02114, USA

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Yassin A. Hassan Prof.,

Yassin A. Hassan Prof.

Department of Nuclear Engineering, Texas A&M University, College Station, TX 77843, USA

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Victor M. Ugaz Prof.,

Victor M. Ugaz Prof.

[email protected]

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA, Fax: (+1) 979-458-1002

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First published: 24 May 2007

https://doi.org/10.1002/ange.200700306

Citations: 8

^†

This work was supported by the National Institutes of Health under grants K22-HG02297 and R01-HG003364. We thank Prof. Mihir Sen for helpful discussions regarding modeling the convective flow. We are also grateful to Ling Zhen for assistance with computational-flow simulations.

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Graphical Abstract

Taschen-PCR: Ein innovativer Thermocycler nutzt die natürliche Konvektion, um langkettige und Multiplex-DNA schnell durch Polymerasekettenreaktion (PCR) zu vervielfältigen. Der einfache Aufbau benötigt ein Minimum an elektrischer Leistung und kann daher in einem batteriebetriebenen Tascheninstrument mit Produktionskosten um 10 US$ umgesetzt werden.

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Volume119, Issue23

June 4, 2007

Pages 4394-4397

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A Pocket-Sized Convective PCR Thermocycler^†