Highly Stable Pyrimidine-Motif Triplex Formation at Physiological pH Values by a Bridged Nucleic Acid Analogue†
S. M. Abdur Rahman Dr.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
On leave from the Faculty of Pharmacy, Dhaka University, Dhaka-1000, Bangladesh
Search for more papers by this authorSayori Seki
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorSatoshi Obika Dr.
Graduate School of Pharmaceutical Sciences, Osaka University
PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan
Search for more papers by this authorSunao Haitani
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorKazuyuki Miyashita Prof.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorTakeshi Imanishi Prof.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorS. M. Abdur Rahman Dr.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
On leave from the Faculty of Pharmacy, Dhaka University, Dhaka-1000, Bangladesh
Search for more papers by this authorSayori Seki
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorSatoshi Obika Dr.
Graduate School of Pharmaceutical Sciences, Osaka University
PRESTO, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan
Search for more papers by this authorSunao Haitani
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorKazuyuki Miyashita Prof.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorTakeshi Imanishi Prof.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan, Fax: (+81) 6-6879-8204
Search for more papers by this authorS.M.A.R. thanks the Japan Society of Promotion of Science (JSPS) for financial support.
Graphical Abstract
Aller guten Dinge sind drei: Eine neuartige überbrückte Nucleinsäure wurde entwickelt, in der die Furanose durch eine sechsgliedrige Brückeneinheit mit einer N-O-Bindung in einer Konformation vom N-Typ fixiert ist (siehe Bild). Oligonucleotide, die aus diesem Rest aufgebaut sind, bilden bei physiologischen pH-Werten stabile Triplexe.
Supporting Information
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