Endlich ist der Weg frei für die Synthese vom Hetisin-artigen Alkaloiden: Ausgehend von 2-Brom-5-methoxyphenethyliodid führte eine Totalsynthese in 40 Stufen zu (±)-Nominin (1). Schlüsselschritte beim Aufbau der komplexen polycyclischen Struktur des Naturstoffs waren die radikalische Cyclisierung eines Enins und die palladiumkatalysierte intramolekulare α-Arylierung eines Aldehyds.

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Total Synthesis of (±)-Nominine, a Heptacyclic Hetisine-Type Aconite Alkaloid^†

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Total Synthesis of (±)-Nominine, a Heptacyclic Hetisine-Type Aconite Alkaloid†

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Total Synthesis of (±)-Nominine, a Heptacyclic Hetisine-Type Aconite Alkaloid^†