Dynamics and Energetics of Hole Trapping in DNA by 7-Deazaguanine
Frederick D. Lewis Prof.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorJianqin Liu
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorXiaoyang Liu Dr.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorXiaobing Zuo
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorRyan T. Hayes
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorMichael R. Wasielewski Prof.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorFrederick D. Lewis Prof.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorJianqin Liu
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorXiaoyang Liu Dr.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorXiaobing Zuo
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorRyan T. Hayes
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorMichael R. Wasielewski Prof.
Department of Chemistry Northwestern University Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-2184
Search for more papers by this authorWe thank R. S. Kalgutkar for advice on the kinetic modeling. This research was supported by grants from the Division of Chemical Sciences, Office of Basic Energy Sciences, US Department of Energy under contracts DE-FG02-96ER14684 (FDL) and DE-FG02-99ER14999 (MRW).
Abstract
Eine tiefe Falle für Löcher ist nach zeitaufgelöster Transienten-Absorptionsspektroskopie und Kinetikmodellierung 7-Desazaguanin (Z) beim Lochtransport in DNA von einer Guanin(G)- zu einer Z-Base über ein oder zwei dazwischen liegende Adenin-Thymin-Basenpaare. Die Gibbs-Energie des Lochtransports von G zu Z beträgt −0.19 eV und ist somit erheblich größer als für GG- oder GGG-Stellen. Damit verhindert Z effektiv die Ladungswanderung in DNA.
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