Volume 114, Issue 6 pp. 1054-1056

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Unprecedented Regiocontrol Using An Aldolase I Antibody

Virginie Maggiotti,

Virginie Maggiotti

University of Oxford The Dyson Perrins Laboratory South Parks Road, Oxford OX1 3QY (UK) Fax: (+44) 1865-275-644

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Marina Resmini Dr.,

Marina Resmini Dr.

Queen Mary, University of London Department of Chemistry Mile End Road, London E1 4NS (UK)

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Véronique Gouverneur Dr.,

Véronique Gouverneur Dr.

[email protected]

University of Oxford The Dyson Perrins Laboratory South Parks Road, Oxford OX1 3QY (UK) Fax: (+44) 1865-275-644

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Virginie Maggiotti,

Virginie Maggiotti

University of Oxford The Dyson Perrins Laboratory South Parks Road, Oxford OX1 3QY (UK) Fax: (+44) 1865-275-644

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Marina Resmini Dr.,

Marina Resmini Dr.

Queen Mary, University of London Department of Chemistry Mile End Road, London E1 4NS (UK)

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Véronique Gouverneur Dr.,

Véronique Gouverneur Dr.

[email protected]

University of Oxford The Dyson Perrins Laboratory South Parks Road, Oxford OX1 3QY (UK) Fax: (+44) 1865-275-644

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First published: 15 March 2002

https://doi.org/10.1002/1521-3757(20020315)114:6<1054::AID-ANGE1054>3.0.CO;2-H

Citations: 9

This work was supported by the University of Oxford (grant B(RE)9862 to V.G. and grant to V.M.) and the Royal Society of Chemistry (RSRG 20750 grant to V.G.). We thank Professor R. A. Lerner for supplying a very generous quantity of antibody 84G3.

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Graphical Abstract

Direkte asymmetrische Aldolreaktionen am weniger substituierten Kohlenstoffatom unmodifizierter unsymmetrischer Ketone gelingen in Gegenwart des kommerziell erhältlichen Aldolase-I-Antikörpers 84G3 [Gl. (1)]. Bei allen Reaktionen war der Enantiomerenüberschuss größer als 94 %. Indem entweder die Aldol- oder die Retro-Aldolreaktion genutzt wird, sind beide Enantiomere zugänglich.

Supporting Information

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Volume114, Issue6

March 15, 2002

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Unprecedented Regiocontrol Using An Aldolase I Antibody

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