Lipids and Arthritis
Lipids and Health
Zouyan He,
Erika Kwek,
Zhen-Yu Chen,
Zouyan He
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorErika Kwek
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorZhen-Yu Chen
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorZouyan He,
Erika Kwek,
Zhen-Yu Chen,
Zouyan He
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorErika Kwek
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorZhen-Yu Chen
The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorFirst published: 17 February 2020
Abstract
It is estimated that 355 million people suffer from arthritis in the world. Rheumatoid arthritis (RA) is the most common type of autoimmune disease that primarily affects the joints. Humans obtain about 25–40% calories from dietary fats. This article summarizes the findings of recent studies regarding the effect of dietary fat on the risk and treatment of RA. The thorough literature review has clearly demonstrated that the effects of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), n-3 polyunsaturated fatty acids (PUFAs), and n-6 polyunsaturated fatty acids (PUFAs) on RA are multifaceted. Research from both animal experiments and human clinical trials provide solid evidence that n-3 PUFAs and MUFAs possess an anti-inflammatory activity and have beneficial effects on RA. In contrast, SFAs may promote arthritis by enhancing inflammation and disturbing bone homeostasis. Amongst n-6 PUFAs, gamma-linolenic acid (GLA) and dihomo-gamma-linolenic acid (DGLA) are antiarthritic, whereas the effects of linoleic acid (LA) and arachidonic acid (ARA) on arthritic progression still remain elusive.
References
- 1Barbour, K.E., Helmick, C.G., Boring, M., and Brady, T.J. (2017). MMWR Morb. Mortal. Wkly Rep. 66: 246–253.
- 2Hootman, J.M., Helmick, C.G., Barbour, K.E. et al. (2016). Arthritis Rheumatol. 68: 1582–1587.
- 3Calabresi, E., Petrelli, F., Bonifacio, A.F. et al. (2018). Clin. Exp. Rheumatol. 36: 175–184.
- 4Gonzalez, A., Icen, M., Kremers, H.M. et al. (2008). J. Rheumatol. 35: 1009–1014.
- 5Aletaha, D., Alasti, F., and Smolen, J.S. (2015). Arthritis Res. Ther. 17: 229.
- 6Van Gaalen, F.A., Van Aken, J., Huizinga, T.W.J. et al. (2004). Arthritis Rheum. 50: 2113–2121.
- 7Choo, S.Y. (2007). Yonsei Med. J. 48: 11–23.
- 8Gregersen, P.K., Silver, J., and Winchester, R.J. (1987). Arthritis Rheum. 30: 1205–1213.
- 9McInnes, I.B., Schett, G., and Engl, N. (2011). J. Med. 365: 2205–2219.
- 10Krabben, A., Huizinga, T.W.J., and van der Helm-van Mil, A.H.M. (2015). Curr. Pharm. Des. 21: 147–169.
- 11Viatte, S., Lee, J.C., Fu, B. et al. (2016). Arthritis Rheumatol. 68: 2629–2636.
- 12Klein, K. and Gay, S. (2015). Curr. Opin. Rheumatol. 27: 76–82.
- 13Smolen, J.S., Aletaha, D., Barton, A. et al. (2018). Nat. Rev. Dis. Primers 8: 18001.
- 14Darrah, E. and Andrade, F. (2018). Curr. Opin. Rheumatol. 30: 72–78.
- 15Brennan, F.M. and McInnes, I.B. (2008). J. Clin. Invest. 118: 3537–3545.
- 16Smolen, J.S., Aletaha, D., and McInnes, I.B. (2016). Lancet 388: 2023–2038.
- 17Choy, E. (2012). Rheumatology 51: v3–v11.
- 18Fattahi, M.J. and Mirshafiey, A. (2012). Arthritis 2012: 239310.
- 19Hoxha, M. (2018). Adv. Med. Sci. 63: 22–29.
- 20Wright, H.L., Moots, R.J., and Edwards, S.W. (2014). Nat. Rev. Rheumatol. 10: 593–601.
- 21Aletaha, D. and Smolen, J.S. (2018). JAMA 320: 1360–1372.
- 22Bugatti, S., Manzo, A., Montecucco, C., and Caporali, R. (2018). Front. Med. 5: 339.
- 23Das, U.N. (2006). Biotechnol. J. 1: 420–439.
- 24Meyer, B.J., Mann, N.J., Lewis, J.L. et al. (2003). Lipids 38: 391–398.
- 25Yaqoo, P. and Calder, P.C. (2007). Br. J. Nutr. 98: S41–S45.
- 26Innes, J.K. and Calder, P.C. (2018). Prostaglandins Leukot. Essent. Fat. Acids 132: 41–48.
- 27Davidson, E.M., Rae, S.A., and Smith, M.J. (1983). Ann. Rheum. Dis. 42: 677–679.
- 28Klickstein, L.B., Shapleigh, C., and Goetzl, E.J. (1980). J. Clin. Invest. 66: 1166–1170.
- 29Martel-Pelletier, J., Pelletier, J.P., and Fahmi, H. (2003). Semin. Arthritis Rheum. 33: 155–167.
- 30Robinson, D.R., Tashjian, A.H., and Levine, L. (1975). J. Clin. Invest. 56: 1181–1188.
- 31Portanova, J.P., Zhang, Y., Anderson, G.D. et al. (1996). J. Exp. Med. 184: 883–891.
- 32Sheibanie, A.F., Khayrullina, T., Safadi, F.F., and Ganea, D. (2007). Arthritis Rheum. 56: 2608–2619.
- 33Calder, P.C. (2007). Br. J. Nutr. 98: 451–453.
- 34Peterson, L.D., Jeffery, N.M., Thies, F. et al. (1998). Lipids 33: 171–180.
- 35Kelley, D.S., Taylor, P.C., Nelson, G.J., and Mackey, B.E. (1998). Lipids 33: 125–130.
- 36Adam, O., Beringer, C., Kless, T. et al. (2003). Rheumatol. Int. 23: 27–36.
- 37Tateishi, N., Kaneda, Y., Kakutani, S. et al. (2015). Lipids Health Dis. 14: 3.
- 38Kakutani, S., Ishikura, Y., Tateishi, N. et al. (2011). Lipids Health Dis. 10: 241.
- 39Sergeant, S., Rahbar, E., and Chilton, F.H. (2016). Eur. J. Pharmacol. 785: 77–86.
- 40Fantone, J.C., Marasco, W.A., Elgas, L.J., and Ward, P.A. (1983). J. Immunol. 130: 1495–1497.
- 41Chilton-Lopez, M., Surette, E., Swan, D.D. et al. (1996). J. Immunol. 156: 2941–2947.
- 42Chapkin, R.S., Miller, C.C., Somers, S.D., and Erickson, K.L. (1988). Biochem. Biophys. Res. Commun. 153: 799–804.
- 43Baker, D.G., Krakauer, K.A., Tate, G. et al. (1989). Arthritis Rheum. 32: 1273–1281.
- 44Brzeski, M., Madhok, R., and Capell, H.A. (1991). Br. J. Rheumatol. 30: 370–372.
- 45Leventhal, L.J., Boyce, E.G., and Zurier, R.B. (1993). Ann. Intern. Med. 119: 867–873.
- 46Zurier, R.B., Rossetti, R.G., Jacobson, E.W. et al. (1996). Arthritis Rheum. 39: 1808–1817.
- 47Cameron, M., Gagnier, J.J., and Chrubasik, S. (2011). Cochrane Database of Syst. Rev. (2): CD002948. doi: 10.1002/14651858.CD002948.pub2.
- 48Liou, Y.A., King, D.J., Zibrik, D., and Innis, S.M. (2007). J. Nutr. 137: 945–952.
- 49Pischon, T., Hankinson, S.E., Hotamisligil, G.S. et al. (2003). Circulation 108: 155–160.
- 50Ferrucci, L., Cherubini, A., Bandinelli, S. et al. (2006). J. Clin. Endocrinol. Metab. 91: 439–446.
- 51Johnson, G.H. and Fritsche, K. (2012). J. Acad. Nutr. Diet. 112: 1029–1041.
- 52Vangaveti, V.N., Jansen, H., Kennedy, R.L., and Malabu, U.H. (2016). Eur. J. Pharmacol. 785: 70–76.
- 53Huang, J.T., Welch, J.S., Ricote, M. et al. (1999). Nature 400: 378–382.
- 54Giaginis, C., Giagini, A., and Theocharis, S. (2009). Pharmacol. Res. 60: 160–169.
- 55Vangaveti, V., Baune, B.T., and Kennedy, R.L. (2010). Ther. Adv. Endocrinol. Metab. 1: 51–60.
- 56Jira, W., Spiteller, G., and Richter, A. (1997). Chem. Phys. Lipids 87: 81–89.
- 57Jira, W., Spiteller, G., and Richter, A. (1998). Z. Naturforsch. C 53: 1061–1071.
- 58He, M., van Wijk, E., Berger, R. et al. (2015). Mediat. Inflamm. 2015: 543541.
- 59Miles, E.A. and Calder, P.C. (2012). Br. J. Nutr. 107: S171–S184.
- 60Volker, D.H., FitzGerald, P.E., and Garg, M.L. (2000). J. Nutr. 130: 559–565.
- 61Leslie, C.A., Gonnerman, W.A., Ullman, M.D. et al. (1985). J. Exp. Med. 162: 1336–1349.
- 62Lee, T.H., Hoover, R.L., Williams, J.D. et al. (1985). N. Engl. J. Med. 312: 1217–1224.
- 63Sperling, R.I., Benincaso, A.I., Knoell, C.T. et al. (1993). J. Clin. Invest. 91: 651–660.
- 64Rees, D., Miles, E.A., Banerjee, T. et al. (2006). Am. J. Clin. Nutr. 83: 331–342.
- 65Kremer, J.M., Lawrence, D.A., Jubiz, W. et al. (1990). Arthritis Rheum. 33: 810–820.
- 66van der Tempel, H., Tulleken, J.E., Limburg, P.C. et al. (1990). Ann. Rheum. Dis. 49: 76–80.
- 67Cleland, L.G., Caughey, G.E., James, M.J., and Proudman, S.M. (2006). J. Rheumatol. 33: 1973–1979.
- 68Calder, P.C. (2015). Biochim. Biophys. Acta 1851: 469–484.
- 69Goldman, D.W., Pickett, W.C., and Goetzl, E.J. (1983). Biochem. Biophys. Res. Commun. 117: 282–288.
- 70Wada, M., DeLong, C.J., Hong, Y.H. et al. (2007). J. Biol. Chem. 282: 22254–22266.
- 71Bagga, D., Wang, L., Farias-Eisner, R. et al. (2003). Proc. Natl. Acad. Sci. U.S.A. 100: 1751–1756.
- 72Sperling, R.I., Weinblatt, M., Robin, J.L. et al. (1987). Arthritis Rheum. 30: 988–997.
- 73Olson, M.V., Liu, Y.C., Dangi, B. et al. (2013). Inflamm. Res. 62: 1003–1013.
- 74Morin, C., Blier, P.U., and Fortin, S. (2015). Arthritis Res. Ther. 17: 142.
- 75Estevão-Silva, C.F., Ames, F.Q., Silva-Comar, F.M.S. et al. (2015). Inflammation 39: 320–326.
- 76Woo, S.J., Lim, K., Park, S.Y. et al. (2015). J. Nutr. Biochem. 26: 713–720.
- 77Kim, J.Y., Lim, K., Kim, K.H. et al. (2018). PLoS ONE 13: e019433.
- 78Endres, S., Ghorbani, R., Kelley, V.E. et al. (1989). N. Engl. J. Med. 320: 265–271.
- 79Meydani, S.N., Endres, S., Woods, M.M. et al. (1991). J. Nutr. 121: 547–555.
- 80Espersen, G.T., Grunnet, N., Lervang, H.H. et al. (1992). Clin. Rheumatol. 11: 393–395.
- 81Kremer, J.M., Lawrence, D.A., Petrillo, G.F. et al. (1995). Arthritis Rheum. 38: 1107–1114.
- 82Kolahi, S., Ghorbanihaghjo, A., Alizadeh, S. et al. (2010). Clin. Biochem. 43: 576–580.
- 83Serhan, C.N. and Chiang, N. (2008). Br. J. Pharmacol. 153: S200–S215.
- 84Hong, S., Gronert, K., Devchand, P.R. et al. (2003). J. Biol. Chem. 278: 14677–14687.
- 85Marcheselli, V.L., Hong, S., Lukiw, W.J. et al. (2003). J. Biol. Chem. 278: 43807–43817.
- 86Arita, M., Ohira, T., Sun, Y.P. et al. (2007). J. Immunol. 178: 3912–3917.
- 87Chiurchiù, V., Leuti, A., Dalli, J. et al. (2016). Sci. Transl. Med. 8: 353ra111.
- 88Giera, M., Ioan-Facsinay, A., Toes, R. et al. (2012). Biochim. Biophys. Acta 1821: 1415–1424.
- 89Norling, L.V., Headland, S.E., Dalli, J. et al. (2016). JCI Insight 1: e85922.
- 90Barden, A.E., Moghaddami, M., Mas, E. et al. (2016). Prostaglandins Leukot. Essent. Fat. Acids 107: 24–29.
- 91Arnardottir, H.H., Dalli, J., Norling, L.V. et al. (2016). J. Immunol. 197: 2362–2368.
- 92Lima-Garcia, J.F., Dutra, R.C., da Silva, K. et al. (2011). Br. J. Pharmacol. 164: 278–293.
- 93Park, C.K., Xu, Z.Z., Liu, T. et al. (2011). J. Neurosci. 31: 18433–18438.
- 94Shapiro, J.A., Koepsell, T.D., Voigt, L.F. et al. (1996). Epidemiology 7: 256–263.
- 95Di Giuseppe, D., Wallin, A., Bottai, M. et al. (2014). Ann. Rheum. Dis. 73: 1949–1953.
- 96Gan, R.W., Young, K.A., Zerbe, G.O. et al. (2016). Rheumatology 55: 367–376.
- 97Gan, R.W., Demoruelle, M.K., Deane, K.D. et al. (2017). Ann. Rheum. Dis. 76: 147–152.
- 98Lourdudoss, C., Di Giuseppe, D., Wolk, A. et al. (2018). Arthritis Care Res. 70: 205–212.
- 99Gioxari, A., Kaliora, A.C., Marantidou, F., and Panagiotakos, D.P. (2018). Nutrition 45: 114–124.
- 100Santos, S., Oliveira, A., and Lopes, C. (2013). Nutr. Res. 33: 687–695.
- 101Fritsche, K.L. (2015). Adv. Nutr. 6: 293S–301S.
- 102Lee, J.Y., Sohn, K.H., Rhee, S.H., and Hwang, D. (2001). J. Biol. Chem. 276: 16683–16689.
- 103Miao, H., Chen, L., Hao, L. et al. (2015). Sci. Rep. 5: 13092.
- 104Ko, J.S., Koh, J.M., So, J.S. et al. (2017). Sci. Rep. 7: 14940.
- 105Alvarez-Garcia, O., Rogers, N.H., Smith, R.G., and Lotz, M.K. (2014). Arthritis Rheumatol. 66: 1779–1788.
- 106Tampakaki, Z.D., Drosatos, K., Siegelin, Y. et al. (2014). J. Bone Miner. Res. 29: 1183–1195.
- 107Lu, B., Driban, J.B., Xu, C. et al. (2017). Arthritis Care Res. 69: 368–375.
- 108Sekar, S., Shafie, S.R., Prasadam, I. et al. (2017). Sci. Rep. 7: 46457.
- 109Pérez-Martínez, P.I., Hernández, V.G., Rodríguez-Espinosa, O. et al. (2016). Mod. Res. Inflamm. 5: 31–44.
- 110Rosillo, M.A., Sánchez-Hidalgo, M., Sánchez-Fidalgo, S. et al. (2016). Eur. J. Nutr. 55: 315–325.
- 111Huffman, K.M., Jessee, R., Andonian, B. et al. (2017). Arthritis Res. Ther. 19: 12.
- 112Coll, T., Eyre, E., Rodríguez-Calvo, R. et al. (2008). J. Biol. Chem. 283: 11107–11116.
- 113Linos, A., Kaklamanis, E., Kontomerkos, A. et al. (1991). Scand. J. Rheumatol. 20: 419–426.
- 114Linos, A., Kaklamani, V.G., Kaklamani, E. et al. (1999). Am. J. Clin. Nutr. 70: 1077–1082.
- 115Matsumoto, Y., Sugioka, Y., Tada, M. et al. (2018). Clin. Nutr. 37: 675–680.
