Structured Lipids and Health
Abstract
Lipids play a pivotal role in human health, growth, and development. The application challenges presented by lipids in their natural form are overcome by production of customized lipids, called structured lipids (SLs). The changes in the triacylglycerol (TAG) molecular species alter their physicochemical as well as nutritional properties. Advances have been made in the area of SL synthesis and applications. Novel SLs enriched with different fatty acids (FAs) have been synthesized for a wide range of medicinal and nutritional applications. The amount of fat and its concentration, type, and stereospecificity of FAs is critical for its metabolism and bioavailability. The correlations of dietary lipids with different diseases and their importance in maintaining homeostasis and overall health are becoming increasingly clear with emerging studies. SLs are beneficial in chronic health conditions, enteral and parental nutrition, infant formulas, sports nutrition, and low calorie fats. This review focusses on the effects of SLs on various health aspects.
References
- 1 Fahy, E., Cotter, D., Sud, M., and Subramaniam, S. (2011). Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1811: 637–647.
- 2 Pande, G. and Akoh, C.C. (2012). Inform 23: 50.
- 3 Fomuso, L.B. and Akoh, C.C. (2001). Food Sci. Technol. 10: 690–698.
- 4
Willis, W.M., Ghazani, S.M., and Marangoni, A.G. (2017). In: Food Lipids: Chemistry, Nutrition, and Biotechnology, 4e (ed. C.C. Akoh), 899–939. Boca Raton, FL: CRC Press.
10.1201/9781315151854-35 Google Scholar
- 5 Marangoni, A.G. and Rousseau, D. (1995). Trends Food Sci. Technol. 6: 329–335.
- 6
Lairon, D. (2009). In: Designing Functional Foods: Measuring and Controlling Food Structure Breakdown and Nutrient Absorption (ed. D.J. McClements and E.A. Decker), 68–93. Boca Raton, FL: CRC Press.
10.1533/9781845696603.1.66 Google Scholar
- 7 Mu, H. and Høy, C.E. (2004). Prog. Lipid Res. 43: 105–133.
- 8 Tiruppathi, C. and Balasubramania, K.A. (1982). Biochim. Biophys. Acta Lipids Lipid Metab. 712: 692–697.
- 9 Rogalska, E., Ransac, S., and Verger, R. (1990). J. Biol. Chem. 265: 20271–20276.
- 10 Christophe, A.B. (2005). In: Handbook of Functional Lipids (ed. C.C. Akoh), 351–362. Boca Raton, FL: CRC Press.
- 11 Ikeda, I., Sasaki, E., Yasunami, H. et al. (1995). Biochim. Biophys. Acta, Lipids Lipid Metab. 1259: 297–304.
- 12
Akoh, C.C. and Kim, B.H. (2017). In: Food Lipids: Chemistry, Nutrition, and Biotechnology, 4e (ed. C.C. Akoh), 941–972. Boca Raton, FL: CRC Press.
10.1201/9781315151854-36 Google Scholar
- 13 Mu, H. and Porsgaard, T. (2005). Prog. Lipid Res. 44: 430–448.
- 14 Karupaiah, T. and Sundram, K. (2007). Nutr. Metab. 4: 1–17.
- 15 Porsgaard, T., Straarup, E.M., and Høy, C.E. (2003). Ann. Nutr. Metab. 47: 132–138.
- 16 Nagata, J.I., Kasai, M., Watanabe, S. et al. (2003). Biosci. Biotechnol. Biochem. 67: 1937–1943.
- 17 Porsgaard, T., Xu, X., Göttsche, J., and Mu, H. (2005). J. Nutr. 135: 1705–1711.
- 18 Christensen, M.S., Høy, C.E., and Redgrave, T.G. (1994). Biochim. Biophys. Acta Lipids Lipid Metab. 1215: 198–204.
- 19 Yoshida, H., Kumamaru, J., Mawatari, M. et al. (1996). Biosci. Biotechnol. Biochem. 60: 1293–1298.
- 20 Jensen, M.M., Christensen, M.S., and Høy, C.E. (1994). Ann. Nutr. Metab. 38: 104–116.
- 21 Straarup, E.M. and Høy, C.E. (2001). Nutr. Res. 21: 1001–1013.
- 22 Couëdelo, L., Vaysse, C., Vaique, E. et al. (2012). J. Nutr. 142: 70–75.
- 23 Lee, K. and Akoh, C.C. (1998). Food Rev. Intl. 14: 17–34.
- 24 Osborn, H.T. and Akoh, C.C. (2002). Comp. Rev. Food Sci. Food Safety (3): 110–120.
- 25 Xu, X., Høy, C. E., Balchen, S., and Adler-Nissen, J. (1997). Specific-structured lipids: Nutritional perspectives and production potentials. Proceedings of International Symposium on the Approaches to Functional Cereals and Oils, 806–813. CCOA, Beijing.
- 26 Kim, J. and Friel, J. (2012). Lipid Technol. 24: 103–105.
- 27 Straarup, E.M., Lauritzen, L., Faerk, J. et al. (2006). J. Pediatr. Gastr. Nutr. 42: 293–299.
- 28 Haddad, I., Mozzon, M., and Frega, N.G. (2012). Eur. Food Res. Technol. 235: 325–332.
- 29 Tomarelli, R.M., Meyer, B.J., Weaber, J.R., and Bernhart, F.W. (1968). J. Nutr. 95: 583–590.
- 30 Morera Pons, S., Castellote Bargallo, A., Campoy Folgoso, C., and Lopez Sabater, M.C. (2000). Eur. J. Clin. Nutr. 54: 878–882.
- 31 Carnielli, V.P., Luijendijk, I.H., van Goudoever, J.B. et al. (1995). Am. J. Clin. Nutr. 61: 1037–1042.
- 32 Carnielli, V.P., Luijendijk, I.H., Van Goudoever, J.B. et al. (1996). J. Pediatr. Gastr. Nutr. 23: 553–560.
- 33 Decker, E.A. (1996). Nutr. Rev. 54: 108–110.
- 34 Kennedy, K., Fewtrell, M.S., Morley, R. et al. (1999). Am. J. Clin. Nutr. 70: 920–927.
- 35 Petit, V., Sandoz, L., and Garcia-Rodenas, C.L. (2017). Prostaglandins Leukot. Essent. Fatty Acids 121: 40–51.
- 36 Yehuda, S., Rabinovitz, S., and Mostofsky, D.I. (2005). Neurobiol. Aging 26: 98–102.
- 37 Maduko, C.O., Park, Y.W., and Akoh, C.C. (2008). J. Am. Oil Chem. Soc. 85: 197–204.
- 38 Pina-Rodriguez, A.M. and Akoh, C.C. (2009). J. Agric. Food Chem. 57: 6748–6756.
- 39 Lee, J.H., Son, J.M., Akoh, C.C. et al. (2010). New Biotechnol. 27: 38–45.
- 40 Teichert, S.A. and Akoh, C.C. (2011). J. Agric. Food Chem. 59: 13300–13310.
- 41 Turan, D., Şahin YeŞilçubuk, N., and Akoh, C.C. (2012). J. Agric. Food Chem. 60: 4402–4407.
- 42 Nagachinta, S. and Akoh, C.C. (2013). J. Am. Oil Chem. Soc. 90: 1141–1149.
- 43 Zou, L. and Akoh, C.C. (2013). Food Chem. 141: 2486–2494.
- 44 Pande, G., Sabir, J.S., Baeshen, N.A., and Akoh, C.C. (2013). J. Agric. Food Chem. 61: 10590–10598.
- 45 Li, R., Pande, G., Sabir, J.S. et al. (2014). J. Am. Oil Chem. Soc. 91: 1377–1385.
- 46 Álvarez, C.A. and Akoh, C.C. (2016). J. Am. Oil Chem. Soc. 93: 531–542.
- 47 Sproston, M.J. and Akoh, C.C. (2016). J. Am. Oil Chem. Soc. 93: 251–265.
- 48
Sidnell, A. and Greenstreet, E. (2011). Nutr. Bull. 36: 373–380.
10.1111/j.1467-3010.2011.01913.x Google Scholar
- 49 Zou, L., Pande, G., and Akoh, C.C. (2016). Annu. Rev. Food Sci. Technol. 7: 139–165.
- 50 Şahin-Yeşilçubuk, N. and Akoh, C.C. (2017). J. Am. Oil Chem. Soc. 94: 1005–1034.
- 51 Li, R., Sabir, J.S., Baeshen, N.A., and Akoh, C.C. (2015). J. Food Sci. 80: H2578–H2584.
- 52 Cai, H., Li, Y., Zhao, M. et al. (2015). PLoS One 10: e0133857.
- 53 Álvarez, C.A. and Akoh, C.C. (2015). J. Am. Oil Chem. Soc. 92: 1003–1014.
- 54 Zou, X., Jin, Q., Guo, Z. et al. (2016). Eur. J. Lipid Sci. Technol. 118: 708–715.
- 55 Faustino, A.R., Osório, N.M., Tecelão, C. et al. (2016). Eur. J. Lipid Sci. Technol. 118: 532–544.
- 56 Ghosh, M., Sengupta, A., Bhattacharyya, D.K., and Ghosh, M. (2016). J. Food Sci. Technol. 53: 2017–2024.
- 57 Zou, X., Jin, Q., Guo, Z. et al. (2016). J. Am. Oil Chem. Soc. 93: 781–792.
- 58 Abed, S.M., Zou, X., Ali, A.H. et al. (2017). Bioresour. Technol. 243: 448–456.
- 59 Liu, S., Dong, X., Wei, F. et al. (2017). J. Food Process. Preserv. 41: e12843.
- 60 Simopoulos, A.P. (2008). Exp. Biol. Med. 233: 674–688.
- 61 Panigrahy, D., Kaipainen, A., Greene, E.R., and Huang, S. (2010). Cancer Metastasis Rev. 29: 723–735.
- 62 Wang, W., Zhu, J., Lyu, F. et al. (2014). Prostaglandins Other Lipid Mediat. 113: 13–20.
- 63 Flachs, P., Rossmeisl, M., Bryhn, M., and Kopecky, J. (2009). Clin. Sci. 116: 1–16.
- 64 O'Keefe, S.F. and Sarnoski, P.J. (2017). In: Food Lipids: Chemistry, Nutrition, and Biotechnology, 4e (ed. C.C. Akoh), 3–36. Boca Raton, FL: CRC Press.
- 65 Kaur, N., Chugh, V., and Gupta, A.K. (2014). J. Food Sci. Technol. 51: 2289–2303.
- 66
Watkins, B.A., Li, Y., Hennig, B., and Toborek, M. (2005). In: Bailey's Industrial Oil and Fat Products, 6e, vol. 1 (ed. F. Shahidi). Hoboken, NJ: Wiley.
10.1002/047167849X.bio025 Google Scholar
- 67 Calder, P.C. (2010). Nutrients 2: 355–374.
- 68 Calder, P.C. (2015). Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1851: 469–484.
- 69 Fukui, M., Kang, K.S., Okada, K., and Zhu, B.T. (2013). J. Cell Biol. 114: 192–203.
- 70 Kansal, S., Negi, A.K., Bhatnagar, A., and Agnihotri, N. (2012). Nutr. Cancer 64: 559–568.
- 71 Sawada, N., Inoue, M., Iwasaki, M. et al. (2012). Gastroenterology 142: 1468–1475.
- 72 Hansson, G.K. (2005). N. Engl. J. Med. 352: 1685–1695.
- 73 Christensen, M.S., Høy, C.E., Becker, C.C., and Redgrave, T.G. (1995). Am. J. Clin. Nutr. 61: 56–61.
- 74 Bandarra, N.M., Lopes, P.A., Martins, S.V. et al. (2016). Nutr. Res. 36: 452–463.
- 75 Lopes, P.A., Bandarra, N.M., Martins, S.V. et al. (2016). J. Food Nutr. Res. 4: 621–632.
- 76 Shimada, Y., Sugihara, A., Maruyama, K. et al. (1996). J. Ferment. Bioeng. 81: 299–303.
- 77 Jennings, B.H. and Akoh, C.C. (2001). Food Chem. 72: 273–278.
- 78 Hamam, F. and Shahidi, F. (2005). Food Chem. 91: 583–591.
- 79 Hamam, F. and Shahidi, F. (2004). J. Am. Oil Chem. Soc. 81: 887–892.
- 80 Hamam, F., Al-Remawi, M., and Nasr, A.R. (2015). Food Nutr. Sci. 6: 314–325.
- 81 de Araújo, M.E.M.B., Campos, P.R.B., Alberto, T.G. et al. (2016). Braz. J. Microbiol. 47: 1006–1013.
- 82 Cedano, J., Rodríguez, A., and Siche, R. (2016). Scientia Agropecuaria 6: 313–323.
- 83 Moreira, D.K.T., Santos, P.S., Gambero, A., and Macedo, G.A. (2017). Food Res. Int. 95: 52–58.
- 84 Sharma, M. and Lokesh, B.R. (2013). J. Food Biochem. 37: 220–230.
- 85 Lee, Y.Y., Tang, T.K., Ab Karim, N.A. et al. (2014). Food Func. 5: 57–64.
- 86
Bakar, A.M.A., Ayob, M.K., and Maskat, M.Y. (2016). AIP Conference Proceedings 1784: 030033.
10.1063/1.4966771 Google Scholar
- 87 Cao, Y., Qi, S., Zhang, Y. et al. (2013). Molecules 18: 3733–3744.
- 88 Zhang, J., Xu, D., Li, X. et al. (2015). Food Sci. 20: 012.
- 89 Kanjilal, S., Shanker, K.S., Rao, B.V.S.K. et al. (2016). Intl. Food Res. J. 23: 854–859.
- 90 Ribeiro, M.D.M., Ming, C.C., Lopes, T.I. et al. (2017). J. Food Sci. Technol. 54: 1146–1157.
- 91 Koba, K. and Yanagita, T. (2014). Obes. Res. Clin. Pract. 8: e525–e532.
- 92 Kim, J.H., Kim, Y., Kim, Y.J., and Park, Y. (2016). Annu. Rev. Food Sci. Technol. 7: 221–244.
- 93 Joseph, S.V., Jacques, H., Plourde, M. et al. (2011). J. Nutr. 141: 1286–1291.
- 94 Petridou, A., Mougios, V., and Sagredos, A. (2003). Lipids 38: 805–811.
- 95 Albers, R., Van der Wielen, R.P.J., Brink, E.J. et al. (2003). Eur. J. Clin. Nutr. 57: 595–603.
- 96 Noone, E.J., Roche, H.M., Nugent, A.P., and Gibney, M.J. (2002). Br. J. Nutr. 88: 243–251.
- 97 Gaullier, J.M., Halse, J., Høye, K. et al. (2005). J. Nutr. 135: 778–784.
- 98 Gaullier, J.M., Halse, J., Høivik, H.O. et al. (2007). Br. J. Nutr. 97: 550–560.
- 99 Chen, S.C., Lin, Y.H., Huang, H.P. et al. (2012). Nutrition 28: 559–565.
- 100 Maurelli, S., Blasi, F., Cossignani, L. et al. (2009). J. Sci. Food Agric. 89: 2595–2600.
- 101 Lee, J.H., Cho, K.H., Lee, K.T., and Kim, M.R. (2005). J. Agric. Food Chem. 53: 7295–7301.
- 102 Lee, J.H., Lee, K.T., Akoh, C.C. et al. (2006). J. Agric. Food Chem. 54: 5416–5421.
- 103 Vu, P.L., Park, R.K., Lee, Y.J. et al. (2007). J. Am. Oil Chem. Soc. 84: 123–128.
- 104 Vu, P.L., Shin, J.A., Lee, Y.J. et al. (2008). Intl. J. Food Sci. Nutr. 59: 95–104.
- 105 Villeneuve, P., Barouh, N., Baréa, B. et al. (2007). Food Chem. 100: 1443–1452.
- 106 Senanayake, S.P.J.N. and Shahidi, F. (2002). J. Food Sci. 67: 2038–2045.
- 107 Lumor, S.E. and Akoh, C.C. (2005). Eur. J. Lipid Sci. Technol. 107: 447–454.
- 108 Adamczak, M. and Bornscheuer, U.T. (2013). Eur. J. Lipid Sci. Technol. 115: 405–412.
- 109 Gudmundsdottir, A.V., Hansen, K.A., Magnusson, C.D., and Haraldsson, G.G. (2015). Tetrahedron 71: 8544–8550.
- 110 Dubey, P., Jayasooriya, A.P., and Cheema, S.K. (2011). Nutr. Metab. Insights 4: 7–17.
- 111 Mozaffarian, D., Aro, A., and Willett, W.C. (2009). Eur. J. Clin. Nutr. 63: S5–S21.
- 112 Mozaffarian, D. and Clarke, R. (2009). Eur. J. Clin. Nutr. 63: S22–S33.
- 113 Mozaffarian, D., Katan, M.B., Ascherio, A. et al. (2006). N. Engl. J. Med. 354: 1601–1613.
- 114 Mozaffarian, D. (2006). Atheroscler. Suppl. 7: 29–32.
- 115 Astorg, P. (2005). Bull. Cancer 92: 670–684.
- 116 Laake, I., Carlsen, M.H., Pedersen, J.I. et al. (2013). Int. J. Cancer 132: 1389–1403.
- 117 Lumor, S.E., Jones, K.C., Ashby, R. et al. (2007). J. Agric. Food Chem. 55: 10692–10702.
- 118 Kim, B.H., Lumor, S.E., and Akoh, C.C. (2008). J. Agric. Food Chem. 56: 8195–8205.
- 119 Jennings, B.H. and Akoh, C.C. (2010). J. Am. Oil Chem. Soc. 87: 411–417.
- 120 Adhikari, P., Shin, J.A., Lee, J.H. et al. (2010). J. Sci. Food Agric. 90: 703–711.
- 121 Adhikari, P., Zhu, X.M., Gautam, A. et al. (2010). Food Chem. 119: 1332–1338.
- 122 Pande, G. and Akoh, C.C. (2012). J. Am. Oil Chem. Soc. 89: 1473–1484.
- 123 Pande, G., Akoh, C.C., and Shewfelt, R.L. (2012). J. Food Sci. 77: C1203–C1210.
- 124 James, M.J., Ursin, V.M., and Cleland, L.G. (2003). Am. J. Clin. Nutr. 77: 1140–1145.
- 125 Hu, P., Xu, X., and Yu, L.L. (2017). LWT-Food Sci. Technol. 76: 156–163.
- 126 Sargent, J.R., Coupland, K., and Wilson, R. (1994). Med. Hypotheses 42: 237–242.
- 127 Wanten, G.J. and Calder, P.C. (2007). Am. J. Clin. Nutr. 85: 1171–1184.
- 128 Long, H., Yang, H., Lin, Y. et al. (2013). Nutr. Cancer 65: 71–75.
- 129 Sánchez-Lara, K., Turcott, J.G., Juárez-Hernández, E. et al. (2014). Clin. Nutr. 33: 1017–1023.
- 130 Baracos, V.E., Mazurak, V.C., and Ma, D.W. (2004). Nutr. Res. Rev. 17: 177–192.
- 131 Piper, S.N., Schade, I., Beschmann, R.B. et al. (2009). Eur. J. Anaesthesiol. 26: 1076–1082.
- 132 Mayer, K. and Seeger, W. (2008). Curr. Opin. Clin. Nutr. Metab. Care 11: 121–127.
- 133 Chambrier, C., Guiraud, M., Gibault, J.P. et al. (1999). Nutrition 15: 274–277.
- 134 Kruimel, J.W., Naber, T.H., Adam van der Vliet, J. et al. (2001). J. Parenter. Enter. Nutr. 25: 237–244.
- 135 Lindgren, B.F., Ruokonen, E., Magnusson-Borg, K., and Takala, J. (2001). Clin. Nutr. 20: 43–48.
- 136 Bellantone, R., Bossola, M., Carriero, C. et al. (1999). J. Parenter. Enter. Nutr. 23: 23–127.
- 137 Puiggròs, C., Sánchez, J., Chacón, P. et al. (2009). J. Parenter. Enter. Nutr. 33: 501–512.
- 138 Swails, W.S., Kenler, A.S., Driscoll, D.F. et al. (1997). J. Parenter. Enter. Nutr. 21: 266–274.
- 139 Chen, J., Yan, J., Cai, G.L. et al. (2013). Chin. Med. J. 126: 2329–2332.
- 140 Zhao, Y. and Wang, C. (2017). BioMed Res. Int. doi: 10.1155/2017/4920134.
- 141 Piper, S.N., Röhm, K.D., Boldt, J. et al. (2008). Eur. J. Anaesthesiol. 25: 557–565.
- 142 Cruz-Hernandez, C., Destaillats, F., Thakkar, S.K. et al. (2016). J. Lipid Res. 57: 2208–2216.
- 143 Wang, X., Li, M., Wang, T. et al. (2014). Process Biochem. 49: 1415–1421.
- 144 Wang, X., Liang, L., Yu, Z. et al. (2014). Eur. J. Lipid Sci. Technol. 116: 627–634.
- 145 Cervera, M.Á.R., Venegas, E.V., Bueno, R.R. et al. (2013). J. Biosci. Bioeng. 115: 518–522.
- 146 Esperón-Rojas, A.A., Baeza-Jiménez, R., Cano-Sarmiento, C., and García, H.S. (2017). J. Oleo Sci. 66: 991–996.
- 147 Sánchez, D.A., Tonetto, G.M., and Ferreira, M.L. (2014). J. Mol. Catal. B Enzym. 100: 7–18.
- 148 Yeoh, C.M., Phuah, E.T., Tang, T.K. et al. (2014). Eur. J. Lipid Sci. Technol. 116: 1654–1663.
- 149 Baeza-Jiménez, R., Miranda, K., García, H.S., and Otero, C. (2013). Grasas Aceites 64: 237–242.
- 150 Cho, K.H., Lee, J.H., Kim, J.M. et al. (2009). J. Med. Food 12: 452–460.
- 151 Kim, B.H. and Akoh, C.C. (2015). J. Food Sci. 80: C1713–C1724.
- 152 Das, K. and Ghosh, M. (2017). Food Chem. Toxicol. 100: 225–238.
- 153 Kim, H.J., Lee, K.T., Lee, M.K. et al. (2006). Ann. Nutr. Metabol. 50: 219–228.
- 154 Küllenberg, D., Taylor, L.A., Schneider, M., and Massing, U. (2012). Lipids Health Dis. 11: 3.
- 155 Li, X., Chen, J.F., Yang, B. et al. (2014). Int. J. Mol. Sci. 15: 15244–15258.
- 156 Zhao, T., Kim, B.H., Garcia, H.S. et al. (2014). Food Chem. 157: 132–140.
- 157 Xi, X., Feng, X., Shi, N. et al. (2016). J. Mol. Catal. B Enzym. 126: 46–55.
- 158 Chen, W., Guo, W., Gao, F. et al. (2017). App. Biochem. Biotechnol. 182: 1037–1052.
- 159 Kim, J.H. and Yoon, S.H. (2014). Food Sci. Biotechnol. 23: 1207–1211.
- 160 Ochoa, A.A., Hernández-Becerra, J.A., Cavazos-Garduño, A. et al. (2013). Biotechnol. Prog. 29: 230–236.
- 161 Ochoa-Flores, A.A., Hernández-Becerra, J.A., Cavazos-Garduño, A. et al. (2017). J. Oleo Sci. doi: 10.5650/jos.ess17087.
- 162 Hachem, M., Géloën, A., Van, A.L. et al. (2016). Mol. Neurobiol. 53: 3205–3215.
- 163 Pandey, K.B. and Rizvi, S.I. (2009). Oxidative Med. Cell. Longev. 2: 270–278.
- 164 Figueroa-Espinoza, M.C., Laguerre, M., Villeneuve, P., and Lecomte, J. (2013). Lipid Technol. 25: 131–134.
- 165 Pande, G. and Akoh, C.C. (2016). J. Am. Oil Chem. Soc. 93: 329–337.
- 166 Durand, E., Jacob, R.F., Sherratt, S. et al. (2017). Eur. J. Lipid Sci. Technol. 119: 1600397.
- 167 Pereira, D.M., Silva, T., Barreiro, S.L. et al. (2017). Chem. Phys. Lipids 206: 16–27.
- 168 Narra, N., Kaki, S.S., Prasad, R.B.N. et al. (2017). Beilstein J. Org. Chem. 13: 26–32.
- 169 Balakrishna, M., Kaki, S.S., Karuna, M.S. et al. (2017). Food Chem. 221: 664–672.