Immunity boosting nutraceuticals: Current trends and challenges
Somnath Basak
Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai, India
Contribution: Writing - original draft
Search for more papers by this authorCorresponding Author
Jyoti Gokhale
Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai, India
Correspondence
Jyoti Gokhale, Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai 400019, India.
Email: [email protected]
Contribution: Writing - review & editing
Search for more papers by this authorSomnath Basak
Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai, India
Contribution: Writing - original draft
Search for more papers by this authorCorresponding Author
Jyoti Gokhale
Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai, India
Correspondence
Jyoti Gokhale, Department of Food Engineering and Technology, Institute of Chemical Technology, Mumbai 400019, India.
Email: [email protected]
Contribution: Writing - review & editing
Search for more papers by this authorAbstract
The immune function of the human body is highly influenced by the dietary intake of certain nutrients and bioactive compounds present in foods. The preventive effects of these bioactive ingredients against various diseases have been well investigated. Functional foods are consumed across various diverse cultures, in some form or the other, which provide benefits greater than the basic nutritional needs. Novel functional foods are being developed using novel bioactive ingredients such as probiotics, polyunsaturated fatty acids, and various phytoconstituents, which have a range of immunomodulatory properties. Apart from immunomodulation, these ingredients also affect immunity by their antioxidant, antibacterial, and antiviral properties. The global pandemic of Severe Acute Respiratory Syndrome Coronavirus-2 has forced the scientific community to race against time to find a proper and effective drug or a vaccine. In this review, various non-pharmacological interventions using nutraceuticals and functional foods have been discussed.
Practical applications
Despite a plethora of research being undertaken to understand the immunity boosting properties of the various bioactive present in food, the findings are not translating to nutraceutical products in the market. Immunity has proved to be one of the most important factors for the health and well-being of an individual, especially when the world has been under the grip of the novel coronavirus Severe Acute Respiratory Syndrome Coronavirus-2. The anti-inflammatory properties of various nutraceuticals can come out as potential inhibitors of the various inflammatory processes such as cytokine storms, usually being observed in COVID 19. This review gives an insight into how various nutraceuticals can help in the prevention of various diseases through different mechanisms. The lack of awareness and proper clinical trials pose a challenge to the nutraceutical industry. This review will help and encourage researchers to further design and develop various functional foods, which might help in building immunity.
CONFLICTS OF INTEREST
The authors declare no conflict of interest.
REFERENCES
- Adhikari, U., Mateu, C. G., Chattopadhyay, K., Pujol, C. A., Damonte, E. B., & Ray, B. (2006). Structure and antiviral activity of sulfated fucans from Stoechospermum marginatum. Phytochemistry, 67(22), 2474–2482. https://doi.org/10.1016/j.phytochem.2006.05.024
- Adiloğlu, A. K., Gönülateş, N., Işler, M., & Senol, A. (2013). Kefir tüketiminin insan bağışıklık sistemi üzerine etkileri: Bir sitokin çalışması [The effect of kefir consumption on human immune system: A cytokine study]. Mikrobiyoloji Bulteni, 47(2), 273–281. https://doi.org/10.5578/mb.4709
- Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Tharakan, S. T., Sung, B., & Anand, P. (2008). Potential of spice-derived phytochemicals for cancer prevention. Planta Medica, 74(13), 1560–1569. https://doi.org/10.1055/s-2008-1074578
- Agil, R., & Hosseinian, F. (2012). Dual functionality of triticale as a novel dietary source of prebiotics with antioxidant activity in fermented dairy products. Plant Foods for Human Nutrition, 67(1), 88–93. https://doi.org/10.1007/s11130-012-0276-2
- Aiba, Y., Ishikawa, H., Tokunaga, M., & Komatsu, Y. (2017). Anti-Helicobacter pylori activity of non-living, heat-killed form of lactobacilli including Lactobacillus johnsonii No.1088. FEMS Microbiology Letters, 364(11). https://doi.org/10.1093/femsle/fnx102
10.1093/femsle/fnx102 Google Scholar
- Alemanno, F. (2020). Glutamate—GABA collateral cycle. In F. Alemanno (Ed.), Biochemistry for anesthesiologists and intensivists (pp. 23–34). Springer. https://doi.org/10.1007/978-3-030-26721-6_4
10.1007/978-3-030-26721-6_4 Google Scholar
- Ali Mirani, Z., Khan, M. N., Siddiqui, A., Khan, F., Aziz, M., Naz, S., Ahmed, A., & Khan, S. I. (2018). Ascorbic acid augments colony spreading by reducing biofilm formation of methicillin-resistant Staphylococcus aureus. Iranian Journal of Basic Medical Sciences, 21(2), 175–180. https://doi.org/10.22038/IJBMS.2018.20714.5398
- Alvarez, S., Herrero, C., Bru, E., & Perdigon, G. (2001). Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice. Journal of Food Protection, 64(11), 1768–1774. https://doi.org/10.4315/0362-028x-64.11.1768
- An, J., Feng, Y., Zheng, J., Addy, M., Zhang, L., & Ren, D. (2020). The immune-enhancing potential of peptide fractions from fermented Spirulina platensis by mixed probiotics. Journal of Food Biochemistry, 44(7), e13245. https://doi.org/10.1111/jfbc.13245
- Azad, M., Sarker, M., & Wan, D. (2018). Immunomodulatory effects of probiotics on cytokine profiles. BioMed Research International, 2018, 8063647. https://doi.org/10.1155/2018/8063647
- Báez-Magaña, M., Díaz-Murillo, V., López-Meza, J. E., & Ochoa-Zarzosa, A. (2018). Immunomodulatory effects of thionin Thi2.1 from Arabidopsis thaliana on bovine mammary epithelial cells. International Immunopharmacology, 57, 47–54. https://doi.org/10.1016/j.intimp.2018.02.001
- Bailey, L. B., & Caudill, M. A. (2012). Folate. In J. W. Erdman, I. A. Macdonald, & S. H. Zeisel (Eds.), Present knowledge in nutrition (pp. 321–342). Wiley-Blackwell. https://doi.org/10.1002/9781119946045.ch21
10.1002/9781119946045.ch21 Google Scholar
- Bandyopadhyay, S. S., Navid, M. H., Ghosh, T., Schnitzler, P., & Ray, B. (2011). Structural features and in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica. Phytochemistry, 72(2–3), 276–283. https://doi.org/10.1016/j.phytochem.2010.11.006
- Biesalski, H. K. (2016). Nutrition meets the microbiome: Micronutrients and the microbiota. Annals of the New York Academy of Sciences, 1372(1), 53–64. https://doi.org/10.1111/nyas.13145
- Bindels, L. B., Porporato, P., Dewulf, E. M., Verrax, J., Neyrinck, A. M., Martin, J. C., Scott, K. P., Buc Calderon, P., Feron, O., Muccioli, G. G., Sonveaux, P., Cani, P. D., & Delzenne, N. M. (2012). Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. British Journal of Cancer, 107(8), 1337–1344. https://doi.org/10.1038/bjc.2012.409
- Bjurstöm, H., Wang, J., Ericsson, I., Bengtsson, M., Liu, Y., Kumar-Mendu, S., Issazadeh-Navikas, S., & Birnir, B. (2008). GABA, a natural immunomodulator of T lymphocytes. Journal of Neuroimmunology, 205(1–2), 44–50. https://doi.org/10.1016/j.jneuroim.2008.08.017
- Blondin, C., Fischer, E., Boisson-Vidal, C., Kazatchkine, M. D., & Jozefonvicz, J. (1994). Inhibition of complement activation by natural sulfated polysaccharides (fucans) from brown seaweed. Molecular Immunology, 31(4), 247–253. https://doi.org/10.1016/0161-5890(94)90121-x
- Böger, R. H. (2007). The pharmacodynamics of L-arginine. The Journal of Nutrition, 137(6 Suppl 2), 1650S–1655S. https://doi.org/10.1093/jn/137.6.1650S
- Bolat, Z. B., Islek, Z., Demir, B. N., Yilmaz, E. N., Sahin, F., & Ucisik, M. H. (2020). Curcumin- and piperine-loaded emulsomes as combinational treatment approach enhance the anticancer activity of curcumin on HCT116 colorectal cancer model. Frontiers in Bioengineering and Biotechnology, 8, 50. https://doi.org/10.3389/fbioe.2020.00050
- Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015). Zinc and its role in immunity and inflammation. Autoimmunity Reviews, 14(4), 277–285. https://doi.org/10.1016/j.autrev.2014.11.008
- Bonvini, A., Coqueiro, A. Y., Tirapegui, J., Calder, P. C., & Rogero, M. M. (2018). Immunomodulatory role of branched-chain amino acids. Nutrition Reviews, 76(11), 840–856. https://doi.org/10.1093/nutrit/nuy037
- Bozonet, S. M., & Carr, A. C. (2019). The role of physiological vitamin C concentrations on key functions of neutrophils isolated from healthy individuals. Nutrients, 11(6), 1363. https://doi.org/10.3390/nu11061363
- Brophy, B., Smolenski, G., Wheeler, T., Wells, D., L'Huillier, P., & Laible, G. (2003). Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein. Nature Biotechnology, 21(2), 157–162. https://doi.org/10.1038/nbt783
- Calder, P. C. (2010). Omega-3 fatty acids and inflammatory processes. Nutrients, 2(3), 355–374. https://doi.org/10.3390/nu2030355
- Cantorna, M. T., Nashold, F. E., & Hayes, C. E. (1994). In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. Journal of Immunology, 152(4), 1515–1522.
- Capó, X., Martorell, M., Sureda, A., Riera, J., Drobnic, F., Tur, J. A., & Pons, A. (2016). Effects of almond- and olive oil-based docosahexaenoic- and vitamin E-enriched beverage dietary supplementation on inflammation associated to exercise and age. Nutrients, 8(10), 619. https://doi.org/10.3390/nu8100619
- Cardenas, H., Arango, D., Nicholas, C., Duarte, S., Nuovo, G. J., He, W., Voss, O. H., Gonzalez-Mejia, M. E., Guttridge, D. C., Grotewold, E., & Doseff, A. I. (2016). Dietary apigenin exerts immune-regulatory activity in vivo by reducing NF-κB activity, halting leukocyte infiltration and restoring normal metabolic function. International Journal of Molecular Sciences, 17(3), 323. https://doi.org/10.3390/ijms17030323
- Carr, A. C., & Maggini, S. (2017). Vitamin C and immune function. Nutrients, 9(11), 1211. https://doi.org/10.3390/nu9111211
- Chaichian, S., Moazzami, B., Sadoughi, F., Haddad Kashani, H., Zaroudi, M., & Asemi, Z. (2020). Functional activities of beta-glucans in the prevention or treatment of cervical cancer. Journal of Ovarian Research, 13(1), 24. https://doi.org/10.1186/s13048-020-00626-7)
- Chen, C. Y., Peng, W. H., Tsai, K. D., & Hsu, S. L. (2007). Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sciences, 81(23–24), 1602–1614. https://doi.org/10.1016/j.lfs.2007.09.028
- Chen, D., Wu, X. Z., & Wen, Z. Y. (2008). Sulfated polysaccharides and immune response: Promoter or inhibitor? Panminerva Medica, 50(2), 177–183.
- Chen, J., & Seviour, R. (2007). Medicinal importance of fungal beta-(1–>3), (1–>6)-glucans. Mycological Research, 111(6), 635–652. https://doi.org/10.1016/j.mycres.2007.02.011
- Chen, J., Wang, R., Wang, M., & Wei, G. W. (2020). Mutations strengthened SARS-CoV-2 infectivity. Journal of Molecular Biology, 432(19), 5212–5226. https://doi.org/10.1016/j.jmb.2020.07.009
- Chen, L., Eapen, M. S., & Zosky, G. R. (2017). Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide. Scientific Reports, 7, 45172. https://doi.org/10.1038/srep45172
- Chen, X., Song, L., Wang, H., Liu, S., Yu, H., Wang, X., Li, R., Liu, T., & Li, P. (2019). Partial characterization, the immune modulation and anticancer activities of sulfated polysaccharides from filamentous microalgae Tribonema sp. Molecules, 24(2), 322. https://doi.org/10.3390/molecules24020322
- Cho, Y.-S., Jung, W.-K., Kim, J.-A., Choi, I.-W., & Kim, S.-K. (2009). Beneficial effects of fucoidan on osteoblastic MG63 cell differentiation. Food Chemistry, 116, 990–994. https://doi.org/10.1016/j.foodchem.2009.03.051
- Cholakov, R., Tumbarski, Y., Yanakieva, V., Dobrev, I., Salim, Y., & Denkova, Z. (2017). Antimicrobial activity of Leuconostoc lactis strain BT17, isolated from a spontaneously fermented cereal beverage (Boza). Journal of Microbiology, Biotechnology and Food Sciences, 7, 47–49. https://doi.org/10.15414/jmbfs.2017.7.1.47-49
- Chung, I., Kwon, S. H., Shim, S. T., & Kyung, K. H. (2007). Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. Journal of Food Science, 72(9), M437–M440. https://doi.org/10.1111/j.1750-3841.2007.00545.x
- Clancy, R. (2003). Immunobiotics and the probiotic evolution. FEMS Immunology and Medical Microbiology, 38(1), 9–12. https://doi.org/10.1016/S0928-8244(03)00147-0
- Colombo, E., Sangiovanni, E., & Dell'agli, M. (2013). A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract. Evidence-based Complementary and Alternative Medicine, 2013, 247145. https://doi.org/10.1155/2013/247145
- Colunga Biancatelli, R., Berrill, M., Catravas, J. D., & Marik, P. E. (2020). Quercetin and vitamin C: An experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19). Frontiers in Immunology, 11, 1451. https://doi.org/10.3389/fimmu.2020.01451
- Cordeiro, M. A., Souza, E., Arantes, R., Balthazar, C. F., Guimarães, J. T., Scudino, H., Silva, H., Rocha, R. S., Freitas, M. Q., Esmerino, E. A., Silva, M. C., Pimentel, T. C., Granato, D., Costa, R., Cruz, A. G., & Martins, F. S. (2019). Fermented whey dairy beverage offers protection against Salmonella enterica ssp. enterica serovar Typhimurium infection in mice. Journal of Dairy Science, 102, 6756–6765. https://doi.org/10.3168/jds.2019-16340
- Córdova-Dávalos, L. E., Jiménez, M., & Salinas, E. (2019). Glycomacropeptide bioactivity and health: A review highlighting action mechanisms and signaling pathways. Nutrients, 11(3), 598. https://doi.org/10.3390/nu11030598
- Coursodon-Boyiddle, C. F., Snarrenberg, C. L., Adkins-Rieck, C. K., Bassaganya-Riera, J., Hontecillas, R., Lawrence, P., Brenna, J. T., Jouni, Z. E., & Dvorak, B. (2012). Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. American Journal of Physiology—Gastrointestinal and Liver Physiology, 303(6), G744–G751. https://doi.org/10.1152/ajpgi.00248.2012
- Cruzat, V. F., Krause, M., & Newsholme, P. (2014). Amino acid supplementation and impact on immune function in the context of exercise. Journal of the International Society of Sports Nutrition, 11(1), 61. https://doi.org/10.1186/s12970-014-0061-8
- Daliu, P., Santini, A., & Novellino, E. (2019). From pharmaceuticals to nutraceuticals: Bridging disease prevention and management. Expert Review of Clinical Pharmacology, 12(1), 1–7. https://doi.org/10.1080/17512433.2019.1552135
- Damonte, E. B., Matulewicz, M. C., & Cerezo, A. S. (2004). Sulfated seaweed polysaccharides as antiviral agents. Current Medicinal Chemistry, 11(18), 2399–2419. https://doi.org/10.2174/0929867043364504
- Das, S., Sarmah, S., Lyndem, S., & Singha Roy, A. (2020). An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study. Journal of Biomolecular Structure & Dynamics, 1–11. Advance online publication. https://doi.org/10.1080/07391102.2020.1763201
10.1080/07391102.2020.1763201 Google Scholar
- Das, U. N. (2020). Can bioactive lipids inactivate coronavirus (COVID-19)? Archives of Medical Research, 51(3), 282–286. https://doi.org/10.1016/j.arcmed.2020.03.004
- de Waard, R., Garssen, J., Bokken, G. C., & Vos, J. G. (2002). Antagonistic activity of Lactobacillus casei strain shirota against gastrointestinal Listeria monocytogenes infection in rats. International Journal of Food Microbiology, 73(1), 93–100. https://doi.org/10.1016/s0168-1605(01)00699-7
- DeFelice, S. L. (1995). The nutraceutical revolution: Its impact on food industry R&D. Trends in Food Science & Technology, 6, 59–61.
- Del Cornò, M., Gessani, S., & Conti, L. (2020). Shaping the innate immune response by dietary glucans: Any role in the control of cancer? Cancers, 12(1), 155. https://doi.org/10.3390/cancers12010155
- DiNicolantonio, J. J., McCarty, M. F., Barroso-Aranda, J., Assanga, S., Lujan, L. M. L., & O'Keefe, J. H. (2021). A nutraceutical strategy for downregulating TGFβ signalling: Prospects for prevention of fibrotic disorders, including post-COVID-19 pulmonary fibrosis. Open Heart, 8, e001663. https://doi.org/10.1136/openhrt-2021-001663
- Doshi, M., Watanabe, S., Niimoto, T., Kawashima, H., Ishikura, Y., Kiso, Y., & Hamazaki, T. (2004). Effect of dietary enrichment with n-3 polyunsaturated fatty acids (PUFA) or n-9 PUFA on arachidonate metabolism in vivo and experimentally induced inflammation in mice. Biological & Pharmaceutical Bulletin, 27(3), 319–323. https://doi.org/10.1248/bpb.27.319
- Duval, D., Demangel, C., Munier-Jolain, K., Miossec, S., & Geahel, I. (1991). Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply. Biotechnology and Bioengineering, 38(6), 561–570. https://doi.org/10.1002/bit.260380602
- Ethiraj, S., Vaithilingam, M., Chandrasekaran, S., Mehra, A., Prakash, S., & Agarwal, A. (2016). Fermentation of beet juice using lactic acid bacteria and its cytotoxic activity against human liver cancer cell lines HepG2. Current Bioactive Compounds, 12(4), 258–263.
10.2174/1573407212666160418163831 Google Scholar
- Fabian, C. J., Kimler, B. F., & Hursting, S. D. (2015). Omega-3 fatty acids for breast cancer prevention and survivorship. Breast Cancer Research, 17(1), 62. https://doi.org/10.1186/s13058-015-0571-6
- Fang, Y. Z., Yang, S., & Wu, G. (2002). Free radicals, antioxidants, and nutrition. Nutrition, 18(10), 872–879. https://doi.org/10.1016/s0899-9007(02)00916-4
- Fernandez, M. A., & Marette, A. (2017). Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties. Advances in Nutrition, 8(1), 155S–164S. https://doi.org/10.3945/an.115.011114
- Field, C. J., Johnson, I. R., & Schley, P. D. (2002). Nutrients and their role in host resistance to infection. Journal of Leukocyte Biology, 71(1), 16–32.
- Ganeshpurkar, A., & Saluja, A. K. (2017). The pharmacological potential of rutin. Saudi Pharmaceutical Journal, 25(2), 149–164. https://doi.org/10.1016/j.jsps.2016.04.025
- Ganguly, S., Sabikhi, L., & Singh, A. K. (2019). Effect of whey-pearl millet-barley based probiotic beverage on Shigella-induced pathogenicity in murine model. Journal of Functional Foods, 54, 498–505. https://doi.org/10.1016/j.jff.2019.01.049
- Ghanem, E. N. B., Clark, S., Du, X., Wu, D., Camilli, A., Leong, J. M., & Meydani, S. N. (2015). The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. The Journal of Immunology, 194(3), 1090–1099.
- Ghanim, H., Sia, C. L., Korzeniewski, K., Lohano, T., Abuaysheh, S., Marumganti, A., Chaudhuri, A., & Dandona, P. (2011). A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. The Journal of Clinical Endocrinology and Metabolism, 96(5), 1409–1414. https://doi.org/10.1210/jc.2010-1812
- Ghanim, H., Sia, C. L., Upadhyay, M., Korzeniewski, K., Viswanathan, P., Abuaysheh, S., Mohanty, P., & Dandona, P. (2010). Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. The American Journal of Clinical Nutrition, 91(4), 940–949. https://doi.org/10.3945/ajcn.2009.28584
- Ghodratizadeh, S., Kanbak, G., Beyramzadeh, M., Dikmen, Z. G., Memarzadeh, S., & Habibian, R. (2014). Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit. Veterinary Research Communications, 38(1), 59–62. https://doi.org/10.1007/s11259-013-9584-8
- Ghosh, R., Chakraborty, A., Biswas, A., & Chowdhuri, S. (2020). Evaluation of green tea polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors—An in silico docking and molecular dynamics simulation study. Journal of Biomolecular Structure & Dynamics, 1–13. Advance online publication. https://doi.org/10.1080/07391102.2020.1779818
10.1080/07391102.2020.1779818 Google Scholar
- Ghosh, T., Srivastava, S. K., Gaurav, A., Kumar, A., Kumar, P., Yadav, A. S., Pathania, R., & Navani, N. K. (2019). A combination of linalool, vitamin c, and copper synergistically triggers reactive oxygen species and DNA damage and inhibits Salmonella enterica subsp. enterica Serovar Typhi and Vibrio fluvialis. Applied and Environmental Microbiology, 85(4), e02487–e2518. https://doi.org/10.1128/AEM.02487-18
- Goh, F. Y., Upton, N., Guan, S., Cheng, C., Shanmugam, M. K., Sethi, G., Leung, B. P., & Wong, W. S. (2012). Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB. European Journal of Pharmacology, 679(1–3), 109–116. https://doi.org/10.1016/j.ejphar.2012.01.002
- Gombart, A. F. (2009). The vitamin D-antimicrobial peptide pathway and its role in protection against infection. Future Microbiology, 4(9), 1151–1165. https://doi.org/10.2217/fmb.09.87
- Gombart, A. F., Pierre, A., & Maggini, S. (2020). A review of micronutrients and the immune system—Working in harmony to reduce the risk of infection. Nutrients, 12(1), 236. https://doi.org/10.3390/nu12010236
- Gong, J., Chen, Q., Yan, Y., & Pang, G. (2014). Effect of casein glycomacropeptide on subunit p65 of nuclear transcription factor-B in lipopolysaccharide-stimulated human colorectal tumor HT-29 cells. Food Science and Human Wellness, 3, 51–55. https://doi.org/10.1016/j.fshw.2014.04.001
10.1016/j.fshw.2014.04.001 Google Scholar
- Goodyear, A., Kumar, A., Ehrhart, E. J., Swanson, K., Grusak, M., Leach, J., Dow, S., McClung, A., & Ryan, E. (2015). Dietary rice bran supplementation prevents Salmonella colonization differentially across varieties and by priming intestinal immunity. Journal of Functional Foods, 18, 653–664. https://doi.org/10.1016/j.jff.2015.08.027
- Gupta, K., Kumar, S., Gupta, R. K., Sharma, A., Verma, A. K., Stalin, K., Chaudhari, B. P., Das, M., Singh, S. P., & Dwivedi, P. D. (2016). Reversion of asthmatic complications and mast cell signalling pathways in BALB/c mice model using quercetin nanocrystals. Journal of Biomedical Nanotechnology, 12(4), 717–731. https://doi.org/10.1166/jbn.2016.2197
- Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019). Effects of omega-3 fatty acids on immune cells. International Journal of Molecular Sciences, 20(20), 5028. https://doi.org/10.3390/ijms20205028
- Hammond, B. G., Mayhew, D. A., Naylor, M. W., Ruecker, F. A., Mast, R. W., & Sander, W. J. (2001). Safety assessment of DHA-rich microalgae from Schizochytrium sp. Regulatory Toxicology and Pharmacology, 33(2), 192–204. https://doi.org/10.1006/rtph.2001.1458
- Han, S. N., Adolfsson, O., Lee, C. K., Prolla, T. A., Ordovas, J., & Meydani, S. N. (2004). Vitamin E and gene expression in immune cells. Annals of the New York Academy of Sciences, 1031, 96–101. https://doi.org/10.1196/annals.1331.010
- Harden, E. A., Falshaw, R., Carnachan, S. M., Kern, E. R., & Prichard, M. N. (2009). Virucidal activity of polysaccharide extracts from four algal species against herpes simplex virus. Antiviral Research, 83(3), 282–289. https://doi.org/10.1016/j.antiviral.2009.06.007
- Harnedy-Rothwell, P., & FitzGerald, R. (2012). Bioactive peptides from marine processing waste and shellfish: A review. Journal of Functional Foods, 4, 5–24. https://doi.org/10.1016/j.jff.2011.09.001
- Haslberger, A., Jacob, U., Hippe, B., & Karlic, H. (2020). Mechanisms of selected functional foods against viral infections with a view on COVID-19: Mini review. Functional Foods in Health and Disease, 10, 195–209. https://doi.org/10.31989/ffhd.v10i5.707
- Helal, N. A., Eassa, H. A., Amer, A. M., Eltokhy, M. A., Edafiogho, I., & Nounou, M. I. (2019). Nutraceuticals' novel formulations: The good, the bad, the unknown and patents involved. Recent Patents on Drug Delivery & Formulation, 13(2), 105–156. https://doi.org/10.2174/1872211313666190503112040
- Helbert, M. (2017). Immunology for medical students (3rd ed.). Elsevier.
- Hemilä, H. (2016). Vitamin E administration may decrease the incidence of pneumonia in elderly males. Clinical Interventions in Aging, 11, 1379–1385. https://doi.org/10.2147/CIA.S114515
- Hemilä, H. (2017). Vitamin C and infections. Nutrients, 9(4), 339. https://doi.org/10.3390/nu9040339
- Hernández-Ledesma, B., Recio, I., & Amigo, L. (2008). Beta-lactoglobulin as source of bioactive peptides. Amino Acids, 35(2), 257–265. https://doi.org/10.1007/s00726-007-0585-1
- Hidari, K. I., Takahashi, N., Arihara, M., Nagaoka, M., Morita, K., & Suzuki, T. (2008). Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga. Biochemical and Biophysical Research Communications, 376(1), 91–95. https://doi.org/10.1016/j.bbrc.2008.08.100
- Hodges, S., Pitsillides, A., Ytrebø, L. & Soper, R. (2017). Anti-inflammatory actions of vitamin K. In J.O. Gordeladze (Ed.), Vitamin K2: Vital for Health and Wellbeing ( 153–168). Croatia: IntechOpen. http://doi.org/10.5772/63891
10.5772/63891 Google Scholar
- Hong, F., Hansen, R. D., Yan, J., Allendorf, D. J., Baran, J. T., Ostroff, G. R., & Ross, G. D. (2003). Beta-glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells. Cancer Research, 63(24), 9023–9031.
- Hong, F., Yan, J., Baran, J. T., Allendorf, D. J., Hansen, R. D., Ostroff, G. R., Xing, P. X., Cheung, N. K., & Ross, G. D. (2004). Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models. Journal of Immunology, 173(2), 797–806. https://doi.org/10.4049/jimmunol.173.2.797
- Hoppenbrouwers, T., Cvejić Hogervorst, J. H., Garssen, J., Wichers, H. J., & Willemsen, L. (2019). Long chain polyunsaturated fatty acids (LCPUFAs) in the prevention of food allergy. Frontiers in Immunology, 10, 1118. https://doi.org/10.3389/fimmu.2019.01118
- Hori, T., Kiyoshima, J., Shida, K., & Yasui, H. (2002). Augmentation of cellular immunity and reduction of influenza virus titer in aged mice fed Lactobacillus casei strain Shirota. Clinical and Diagnostic Laboratory Immunology, 9(1), 105–108. https://doi.org/10.1128/cdli.9.1.105-108.2002
- Hou, D. X., Luo, D., Tanigawa, S., Hashimoto, F., Uto, T., Masuzaki, S., Fujii, M., & Sakata, Y. (2007). Prodelphinidin B-4 3'-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-kappaB pathway. Biochemicalpharmacology, 74(5), 742–751. https://doi.org/10.1016/j.bcp.2007.06.006
- Hoxha, M., Zoto, M., Deda, L., & Vyshka, G. (2014). Vitamin D and its role as a protective factor in allergy. International Scholarly Research Notices, 2014, 951946. https://doi.org/10.1155/2014/951946
- Hsieh, C. C., Chou, M. J., & Wang, C. H. (2017). Lunasin attenuates obesity-related inflammation in RAW264.7 cells and 3T3-L1 adipocytes by inhibiting inflammatory cytokine production. PLoS One, 12(2), e0171969. https://doi.org/10.1371/journal.pone.0171969
- Huang, R. Y., Yu, Y. L., Cheng, W. C., OuYang, C. N., Fu, E., & Chu, C. L. (2010). Immunosuppressive effect of quercetin on dendritic cell activation and function. The Journal of Immunology, 184(12), 6815–6821. https://doi.org/10.4049/jimmunol.0903991
- Ikejima, K., Iimuro, Y., Forman, D. T., & Thurman, R. G. (1996). A diet containing glycine improves survival in endotoxin shock in the rat. The American Journal of Physiology, 271(1 Pt 1), G97–G103. https://doi.org/10.1152/ajpgi.1996.271.1.G97
- Im, D. S. (2012). Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs. Progress in Lipid Research, 51(3), 232–237. https://doi.org/10.1016/j.plipres.2012.02.003
- Ismail, M. M., Hamad, M. F., & Elraghy, E. M. (2018). Using goat's milk, barley flour, honey, and probiotic to manufacture of functional dairy product. Probiotics and Antimicrobial Proteins, 10(4), 677–691. https://doi.org/10.1007/s12602-017-9316-4
- Jafarinia, M., Sadat Hosseini, M., Kasiri, N., Fazel, N., Fathi, F., Ganjalikhani Hakemi, M., & Eskandari, N. (2020). Quercetin with the potential effect on allergic diseases. Allergy, Asthma, and Clinical Immunology, 16, 36. https://doi.org/10.1186/s13223-020-00434-0
- Jain, S. K., & Parsanathan, R. (2020). Can vitamin D and L-cysteine co-supplementation reduce 25(OH)-vitamin D deficiency and the mortality associated with COVID-19 in African Americans? Journal of the American College of Nutrition, 1–6. Advance online publication. https://doi.org/10.1080/07315724.2020.1789518
10.1080/07315724.2020.1789518 Google Scholar
- Jamois, F., Ferrieres, V., Guegan, J. P., Yvin, J. C., Plusquellec, D., & Vetvicka, V. (2005). Glucan-like synthetic oligosaccharides: Iterative synthesis of linear oligo-β-(1,3)-glucans and immunostimulatory effects. Glycobiology, 15(4), 393–407. https://doi.org/10.1093/glycob/cwi020
- Jeffery, L. E., Burke, F., Mura, M., Zheng, Y., Qureshi, O. S., Hewison, M., Walker, L. S., Lammas, D. A., Raza, K., & Sansom, D. M. (2009). 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. Journal of Immunology, 183(9), 5458–5467. https://doi.org/10.4049/jimmunol.0803217
- Jones, A. L., Hulett, M. D., & Parish, C. R. (2005). Histidine-rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems. Immunology and Cell Biology, 83(2), 106–118. https://doi.org/10.1111/j.1440-1711.2005.01320.x
- Jose, D. G., & Good, R. A. (1973). Quantitative effects of nutritional essential amino acid deficiency upon immune responses to tumors in mice. The Journal of Experimental Medicine, 137(1), 1–9. https://doi.org/10.1084/jem.137.1.1
- Jung, J., Paik, H. D., Yoon, H. J., Jang, H. J., Jeewanthi, R. K., Jee, H. S., Li, X., Lee, N. K., & Lee, S. K. (2016). Physicochemical characteristics and antioxidant capacity in yogurt fortified with red ginseng extract. Korean Journal for Food Science of Animal Resources, 36(3), 412–420. https://doi.org/10.5851/kosfa.2016.36.3.412
- Kaila, M., Isolauri, E., Soppi, E., Virtanen, E., Laine, S., & Arvilommi, H. (1992). Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric Research, 32(2), 141–144. https://doi.org/10.1203/00006450-199208000-00002
- Kamau, S., Cheison, S. C., Chen, W., Liu, X. M., & Lu, R. R. (2010). Alpha-lactalbumin: Its production technologies and bioactive peptides. Comprehensive Reviews in Food Science and Food Safety, 9, 197–212. https://doi.org/10.1111/j.1541-4337.2009.00100
- Kaneki, M., Hodges, S. J., Hosoi, T., Fujiwara, S., Lyons, A., Crean, S. J., Ishida, N., Nakagawa, M., Takechi, M., Sano, Y., Mizuno, Y., Hoshino, S., Miyao, M., Inoue, S., Horiki, K., Shiraki, M., Ouchi, Y., & Orimo, H. (2001). Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: Possible implications for hip-fracture risk. Nutrition, 17(4), 315–321. https://doi.org/10.1016/s0899-9007(00)00554-2
- Kato, I., Tanaka, K., & Yokokura, T. (1999). Lactic acid bacterium potently induces the production of interleukin-12 and interferon-gamma by mouse splenocytes. International Journal of Immunopharmacology, 21(2), 121–131. https://doi.org/10.1016/s0192-0561(98)00072-1
- Kelly, B., & Pearce, E. L. (2020). Amino assets: How amino acids support immunity. Cell Metabolism, 32(2), 154–175. https://doi.org/10.1016/j.cmet.2020.06.010
- Khatua, S., Chandra, S., & Acharya, K. (2021). Hot alkali-extracted antioxidative crude polysaccharide from a novel mushroom enhances immune response via TLR-mediated NF-κB activation: A strategy for full utilization of a neglected tribal food. Journal of Food Biochemistry, 45(1), e13594. https://doi.org/10.1111/jfbc.13594
- Kieliszek, M., & Lipinski, B.(2020). Selenium supplementation in the prevention of coronavirus infections (COVID-19). Medical Hypotheses, 143, 109878. https://doi.org/10.1016/j.mehy.2020.109878
- Kiewiet, M. B., Dekkers, R., van Gool, M. P., Ulfman, L. H., Groeneveld, A., Faas, M. M., & de Vos, P. (2018). Identification of a TLR2 inhibiting wheat hydrolysate. Molecular Nutrition & Food Research, 62(23), 1800716. https://doi.org/10.1002/mnfr.201800716
- Kim, E. K., Kwon, K. B., Song, M. Y., Han, M. J., Lee, J. H., Lee, Y. R., Lee, J. H., Ryu, D. G., Park, B. H., & Park, J. W. (2007). Flavonoids protect against cytokine-induced pancreatic beta-cell damage through suppression of nuclear factor kappaB activation. Pancreas, 35(4), e1–e9. https://doi.org/10.1097/mpa.0b013e31811ed0d2
- Kim, G. D., Lee, S. E., Park, Y. S., Shin, D. H., Park, G. G., & Park, C. S. (2014). Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic dermatitis-like symptoms in NC/Nga mice. Food and Chemical Toxicology, 66, 341–349. https://doi.org/10.1016/j.fct.2014.01.057
- Kim, S. P., Park, S. O., Lee, S. J., Nam, S. H., & Friedman, M. (2014). A Polysaccharide isolated from the liquid culture of Lentinus edodes (Shiitake) mushroom mycelia containing black rice bran protects mice against salmonellosis through upregulation of the Th1 immune reaction. Journal of Agricultural and Food Chemistry, 62(11), 2384–2391. https://doi.org/10.1021/jf405223q
- Kiremidjian-Schumacher, L., & Roy, M. (1998). Selenium and immune function. Zeitschrift fur Ernahrungswissenschaft, 37(Suppl 1), 50–56.
- Kitabayashi, C., Fukada, T., Kanamoto, M., Ohashi, W., Hojyo, S., Atsumi, T., Ueda, N., Azuma, I., Hirota, H., Murakami, M., & Hirano, T. (2010). Zinc suppresses Th17 development via inhibition of STAT3 activation. International Immunology, 22(5), 375–386. https://doi.org/10.1093/intimm/dxq017
- Kjer-Nielsen, L., Patel, O., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., Williamson, N. A., Purcell, A. W., Dudek, N. L., McConville, M. J., O'Hair, R. A., Khairallah, G. N., Godfrey, D. I., Fairlie, D. P., Rossjohn, J., & McCluskey, J. (2012). MR1 presents microbial vitamin B metabolites to MAIT cells. Nature, 491(7426), 717–723. https://doi.org/10.1038/nature11605
- Kulkarni, S. A., Nagarajan, S. K., Ramesh, V., Palaniyandi, V., Selvam, S. P., & Madhavan, T. (2020). Computational evaluation of major components from plant essential oils as potent inhibitors of SARS-CoV-2 spike protein. Journal of Molecular Structure, 1221, 128823. https://doi.org/10.1016/j.molstruc.2020.128823.
- Kuntz, S., Kunz, C., Herrmann, J., Borsch, C. H., Abel, G., Fröhling, B., Dietrich, H., & Rudloff, S. (2014). Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: Results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study. The British Journal of Nutrition, 112(6), 925–936. https://doi.org/10.1017/S0007114514001482
- Kwak, J. H., Baek, S. H., Woo, Y., Han, J. K., Kim, B. G., Kim, O. Y., & Lee, J. H. (2012). Beneficial immunostimulatory effect of short-term Chlorella supplementation: Enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial). Nutrition Journal, 11, 53. https://doi.org/10.1186/1475-2891-11-53
- Kwon, P. S., Oh, H., Kwon, S. J., Jin, W., Zhang, F., Fraser, K., Hong, J. J., Linhardt, R. J., & Dordick, J. S. (2020). Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro. Cell Discovery, 6, 50. https://doi.org/10.1038/s41421-020-00192-8
- Lai, C. C., Shih, T. P., Ko, W. C., Tang, H. J., & Hsueh, P. R. (2020). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. International Journal of Antimicrobial Agents, 55(3), 105924. https://doi.org/10.1016/j.ijantimicag.2020.105924.
- Lee, N. K., Jeong, J. H., Oh, J., Kim, Y., Ha, Y. S., & Jeong, Y. S. (2015). Conversion of flavonols kaempferol and quercetin in mulberry (Morus alba L.) leaf using plant-fermenting Lactobacillus plantarum. Journal of Food Biochemistry, 39(6), 765–770. https://doi.org/10.1111/jfbc.12176
- Lee, S. H., Cekanova, M., & Baek, S. J. (2008). Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis, 47(3), 197–208. https://doi.org/10.1002/mc.20374
- Leiro, J. M., Castro, R., Arranz, J. A., & Lamas, J. (2007). Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh. International Immunopharmacology, 7(7), 879–888. https://doi.org/10.1016/j.intimp.2007.02.007
- Li, P., Yin, Y. L., Li, D., Kim, S. W., & Wu, G. (2007). Amino acids and immune function. The British Journal of Nutrition, 98(2), 237–252. https://doi.org/10.1017/S000711450769936X
- Li, W., Sun, Y. N., Yan, X. T., Yang, S. Y., Kim, S., Lee, Y. M., Koh, Y. S., & Kim, Y. H. (2014). Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. Archives of Pharmacal Research, 37(2), 186–192. https://doi.org/10.1007/s12272-013-0174-7
- Lin, S. C., Ho, C. T., Chuo, W. H., Li, S., Wang, T. T., & Lin, C. C. (2017). Effective inhibition of MERS-CoV infection by resveratrol. BMC Infectious Diseases, 17(1), 144. https://doi.org/10.1186/s12879-017-2253-8
- Lin, Y. T., Kwon, Y. I., Labbe, R. G., & Shetty, K. (2005). Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies. Applied and Environmental Microbiology, 71(12), 8558–8564. https://doi.org/10.1128/AEM.71.12.8558-8564.2005
- Link-Amster, H., Rochat, F., Saudan, K. Y., Mignot, O., & Aeschlimann, J. M. (1994). Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunology and Medical Microbiology, 10(1), 55–63. https://doi.org/10.1111/j.1574-695X.1994.tb00011
- Liu, Z., & Ying, Y. (2020). The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia. Frontiers in Cell and Developmental Biology, 8, 479. https://doi.org/10.3389/fcell.2020.00479
- Luo, Z., Su, K., & Zhang, X. (2020). Potential of plant proteins digested in silico by gastrointestinal enzymes as nutritional supplement for COVID-19 patients. Plant Foods for Human Nutrition, 75(4), 583–591. https://doi.org/10.1007/s11130-020-00850-y
- Ma, E. H., Bantug, G., Griss, T., Condotta, S., Johnson, R. M., Samborska, B., … Jones, R. G. (2017). Serine is an essential metabolite for effector T cell expansion. Cell Metabolism, 25(2), 345–357. https://doi.org/10.1016/j.cmet.2016.12.011
- Ma, Y., Wu, X., Giovanni, V., & Meng, X. (2017). Effects of soybean oligosaccharides on intestinal microbial communities and immune modulation in mice. Saudi Journal of Biological Sciences, 24(1), 114–121. https://doi.org/10.1016/j.sjbs.2016.09.004
- Maggini, S. (2010). Feeding the immune system: The role of micronutrients in restoring resistance to infections. Cab Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 98(3), 1–21.
- Maggini, S., Beveridge, S., Sorbara, J. P., & Senatore, G. (2008). Feeding the immune system: The role of micronutrients in restoring resistance to infections. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 3, 1–21. https://doi.org/10.1079/PAVSNNR20083098
10.1079/PAVSNNR20083098 Google Scholar
- Maggini, S., Pierre, A., & Calder, P. C. (2018). Immune function and micronutrient requirements change over the life course. Nutrients, 10(10), 1531. https://doi.org/10.3390/nu10101531
- Maggini, S., Wintergerst, E. S., Beveridge, S., & Hornig, D. H. (2007). Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. The British Journal of Nutrition, 98(Suppl 1), S29–S35. https://doi.org/10.1017/S0007114507832971
- Magrone, T., & Jirillo, E. (2013). The interplay between the gut immune system and microbiota in health and disease: Nutraceutical intervention for restoring intestinal homeostasis. Current Pharmaceutical Design, 19(7), 1329–1342. https://doi.org/10.2174/138161213804805793
- Małaczewska, J., Wojcik, R., Jung, L., & Siwicki, A. (2010). The effect of Biolex Beta-HP on the selected parameters of biochemical, specific and non-specific humoral and cellular immunity in rats. Bulletin- Veterinary Institute in Pulawy, 54, 75–80.
- Manach, C., Morand, C., Gil-Izquierdo, A., Bouteloup-Demange, C., & Rémésy, C. (2003). Bioavailability in humans of the flavanone hesperidin and narirutin after the ingestion of two doses of orange juice. European Journal of Clinical Nutrition, 57(2), 235–242. https://doi.org/10.1038/sj.ejcn.1601547
- Manicassamy, S., & Pulendran, B. (2009). Retinoic acid-dependent regulation of immune responses by dendritic cells and macrophages. Seminars in Immunology, 21(1), 22–27. https://doi.org/10.1016/j.smim.2008.07.007
- Marcheselli, V. L., Mukherjee, P. K., Arita, M., Hong, S., Antony, R., Sheets, K., Winkler, J. W., Petasis, N. A., Serhan, C. N., & Bazan, N. G. (2010). Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 82(1), 27–34. https://doi.org/10.1016/j.plefa.2009.10.010
- Maywald, M., Wang, F., & Rink, L. (2018). Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells. Journal of Trace Elements in Medicine and Biology, 50, 482–488. https://doi.org/10.1016/j.jtemb.2018.02.004
- McDaniel, K. L., Restori, K. H., Dodds, J. W., Kennett, M. J., Ross, A. C., & Cantorna, M. T. (2015). Vitamin A-deficient hosts become nonsymptomatic reservoirs of Escherichia coli-like enteric infections. Infection and Immunity, 83(7), 2984–2991. https://doi.org/10.1128/IAI.00201-15
- Mena, P., Domínguez-Perles, R., Gironés-Vilaplana, A., Baenas, N., García-Viguera, C., & Villaño, D. (2014). Flavan-3-ols, anthocyanins, and inflammation. IUBMB Life, 66(11), 745–758. https://doi.org/10.1002/iub.1332
- Molina, N., Morandi, A. C., Bolin, A. P., & Otton, R. (2014). Comparative effect of fucoxanthin and vitamin C on oxidative and functional parameters of human lymphocytes. International Immunopharmacology, 22(1), 41–50. https://doi.org/10.1016/j.intimp.2014.06.026
- Morais, A., Passos, T. S., Maciel, B., & da Silva-Maia, J. K. (2020). Can probiotics and diet promote beneficial immune modulation and purine control in coronavirus infection? Nutrients, 12(6), 1737. https://doi.org/10.3390/nu12061737
- Morita, H., He, F., Fuse, T., Ouwehand, A. C., Hashimoto, H., Hosoda, M., Mizumachi, K., & Kurisaki, J. (2002). Cytokine production by the murine macrophage cell line J774.1 after exposure to lactobacilli. Bioscience, Biotechnology, and Biochemistry, 66(9), 1963–1966. https://doi.org/10.1271/bbb.66.1963
- Moughan, P. J., Rutherfurd-Markwick, K., & (2013). Food bioactive proteins and peptides: Antimicrobial, immunomodulatory and anti-inflammatory effects. In Philip C. Calder & Praveen Yaqoob (Eds.), Diet, immunity and inflammation, Woodhead Publishing Series in Food Science, Technology and Nutrition, (pp. 313–340). Sawston, UK: Woodhead Publishing. https://doi.org/10.1533/9780857095749.3.313
10.1533/9780857095749.3.313 Google Scholar
- Moura, C. S., Lollo, P., Morato, P. N., Risso, E. M., & Amaya-Farfan, J. (2017). Modulatory effects of arginine, glutamine and branched-chain amino acids on heat shock proteins, immunity and antioxidant response in exercised rats. Food & Function, 8(9), 3228–3238. https://doi.org/10.1039/c7fo00465f
- Murphy, E. J., Masterson, C., Rezoagli, E., O'Toole, D., Major, I., Stack, G. D., Lynch, M., Laffey, J. G., & Rowan, N. J. (2020). β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies. The Science of the Total Environment, 732, 139330. https://doi.org/10.1016/j.scitotenv.2020.139330.
- Myneni, V. D., & Mezey, E. (2018). Immunomodulatory effect of vitamin K2: Implications for bone health. Oral Diseases, 24(1–2), 67–71. https://doi.org/10.1111/odi.12759
- Nagao, F., Nakayama, M., Muto, T., & Okumura, K. (2000). Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the immune system in healthy human subjects. Bioscience, Biotechnology, and Biochemistry, 64(12), 2706–2708. https://doi.org/10.1271/bbb.64.2706
- Ndiaye, F., Vuong, T., Duarte, J., Aluko, R. E., & Matar, C. (2012). Antioxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds. European Journal of Nutrition, 51(1), 29–37. https://doi.org/10.1007/s00394-011-0186-3
- Nesaretnam, K., Mahalingam, D., Radhakrishnan, A., & Premier, R. (2010). Supplementation of tocotrienol-rich fraction increases interferon-gamma production in ovalbumin-immunized mice. European Journal of Lipid Science and Technology, 112, 531–536. https://doi.org/10.1002/ejlt.200900193
- Newsholme, P., Brennan, L., Rubi, B., & Maechler, P. (2005). New insights into amino acid metabolism, beta-cell function and diabetes. Clinical Science, 108(3), 185–194. https://doi.org/10.1042/CS20040290
- Newsholme, P., & Newsholme, E. A. (1989). Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture. The Biochemical Journal, 261(1), 211–218. https://doi.org/10.1042/bj2610211
- Nie, C., He, T., Zhang, W., Zhang, G., & Ma, X. (2018). Branched chain amino acids: beyond nutrition metabolism. International Journal of Molecular Sciences, 19(4), 954. https://doi.org/10.3390/ijms19040954
- Nouari, W., Ysmail-Dahlouk, L., & Aribi, M. (2016). Vitamin D3 enhances bactericidal activity of macrophage against Pseudomonas aeruginosa. International Immunopharmacology, 30, 94–101. https://doi.org/10.1016/j.intimp.2015.11.033
- Owen, J. A., Punt, J., & Stranford, S.A. & (2013). Overview of the Immune System. In L. Schultz, E. Champion & E. Pech (Eds.), Kuby Immunology ( 7th ed., pp. 1–26). New York: W. H. Freeman and Company.
- Pal, S., Bhattacharyya, S., Choudhuri, T., Datta, G. K., Das, T., & Sa, G. (2005). Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detection and Prevention, 29(5), 470–478. https://doi.org/10.1016/j.cdp.2005.05.003
- Pallin, A., Agback, P., Jonsson, H., & Roos, S. (2016). Evaluation of growth, metabolism and production of potentially bioactive components during fermentation of barley with Lactobacillus reuteri. Food Microbiology, 57, 159–171. https://doi.org/10.1016/j.fm.2016.02.011
- Pan, M. H., Maresz, K., Lee, P. S., Wu, J. C., Ho, C. T., Popko, J., Mehta, D. S., Stohs, S. J., & Badmaev, V. (2016). Inhibition of TNF-α, IL-1α, and IL-1β by pretreatment of human monocyte-derived macrophages with menaquinone-7 and cell activation with TLR agonists in vitro. Journal of Medicinal Food, 19(7), 663–669. https://doi.org/10.1089/jmf.2016.0030
- Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019). Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Frontiers in Immunology, 10, 277. https://doi.org/10.3389/fimmu.2019.00277
- Pasatiempo, A. M., Kinoshita, M., Taylor, C. E., & Ross, A. C. (1990). Antibody production in vitamin A-depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens. FASEB Journal, 4(8), 2518–2527. https://doi.org/10.1096/fasebj.4.8.2110538
- Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993). A revised structure for fucoidan may explain some of its biological activities. The Journal of Biological Chemistry, 268(29), 21770–21776. https://doi.org/10.1016/S0021-9258(20)80609-7
- Patil, S. P., Goswami, A., Kalia, K., & Kate, A. S. (2020). Plant-derived bioactive peptides: A treatment to cure diabetes. International Journal of Peptide Research and Therapeutics, 26(2), 955–968. https://doi.org/10.1007/s10989-019-09899-z
- Paturi, G., Butts, C. A., Monro, J. A., & Hedderley, D. (2018). Effects of blackcurrant and dietary fibers on large intestinal health biomarkers in rats. Plant Foods for Human Nutrition, 73(1), 54–60. https://doi.org/10.1007/s11130-018-0652-7
- Peluso, I., Raguzzini, A., Villano, D. V., Cesqui, E., Toti, E., Catasta, G., & Serafini, M. (2012). High fat meal increase of IL-17 is prevented by ingestion of fruit juice drink in healthy overweight subjects. Current Pharmaceutical Design, 18(1), 85–90. https://doi.org/10.2174/138161212798919020
- Peng, F., Du, Q., Peng, C., Wang, N., Tang, H., Xie, X., Shen, J., & Chen, J. (2015). A review: The pharmacology of isoliquiritigenin. Phytotherapy Research, 29(7), 969–977. https://doi.org/10.1002/ptr.5348
- Pereira, L., & Critchley, A. T. (2020). The COVID 19 novel coronavirus pandemic 2020: Seaweeds to the rescue? Why does substantial, supporting research about the antiviral properties of seaweed polysaccharides seem to go unrecognized by the pharmaceutical community in these desperate times? Journal of Applied Phycology, 1–3. Advance online publication. https://doi.org/10.1007/s10811-020-02143-y
10.1007/s10811?020?02143?y Google Scholar
- Perianayagam, M. C., Oxenkrug, G. F., & Jaber, B. L. (2005). Immune-modulating effects of melatonin, N-acetylserotonin, and N-acetyldopamine. Annals of the New York Academy of Sciences, 1053, 386–393. https://doi.org/10.1111/j.1749-6632.2005.tb00046.x
- Petro, T. M., & Bhattacharjee, J. K. (1981). Effect of dietary essential amino acid limitations upon the susceptibility to Salmonella typhimurium and the effect upon humoral and cellular immune responses in mice. Infection and Immunity, 32(1), 251–259. https://doi.org/10.1128/IAI.32.1.251-259.1981
- Piqué, N., Berlanga, M., & Miñana-Galbis, D. (2019). Health benefits of heat-killed (tyndallized) probiotics: An overview. International Journal of Molecular Sciences, 20(10), 2534. https://doi.org/10.3390/ijms20102534
- Platten, M., Ho, P. P., Youssef, S., Fontoura, P., Garren, H., Hur, E. M., Gupta, R., Lee, L. Y., Kidd, B. A., Robinson, W. H., Sobel, R. A., Selley, M. L., & Steinman, L. (2005). Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Science, 310(5749), 850–855. https://doi.org/10.1126/science.1117634
- Pothuraju, R., Sharma, R. K., Kavadi, P. K., Chagalamarri, J., Jangra, S., Bhakri, G., & De, S. (2016). Anti-obesity effect of milk fermented by Lactobacillus plantarum NCDC 625 alone and in combination with herbs on high fat diet fed C57BL/6J mice. Beneficial Microbes, 7(3), 375–385. https://doi.org/10.3920/BM2015.0083
- Rahayu, R. P., Prasetyo, R. A., Purwanto, D. A., Kresnoadi, U., Iskandar, R., & Rubianto, M. (2018). The immunomodulatory effect of green tea (Camellia sinensis) leaves extracts on immunocompromised Wistar rats infected by Candida albicans. Veterinary World, 11(6), 765–770. https://doi.org/10.14202/vetworld.2018.765-770
- Rail, L. C., & Meydani, S. N. (2009). Vitamin B6 and immune competence. Nutrition Reviews, 51(8), 217–225. https://doi.org/10.1111/j.1753-4887.1993.tb03109.x
10.1111/j.1753?4887.1993.tb03109.x Google Scholar
- Raso, G. M., Meli, R., Di Carlo, G., Pacilio, M., & Di Carlo, R. (2001). Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sciences, 68(8), 921–931. https://doi.org/10.1016/s0024-3205(00)00999-1
- Ratha, S. K., Renuka, N., Rawat, I., & Bux, F. (2021). Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases. Nutrition, 83, 111089. https://doi.org/10.1016/j.nut.2020.111089
- Razdan, K., Singh, K., & Singh, D. (2020). Vitamin D levels and COVID-19 susceptibility: Is there any correlation? Medicine in Drug Discovery, 7, 100051. https://doi.org/10.1016/j.medidd.2020.100051
- Rizzello, C. G., Lorusso, A., Russo, V., Pinto, D., Marzani, B., & Gobbetti, M. (2017). Improving the antioxidant properties of quinoa flour through fermentation with selected autochthonous lactic acid bacteria. International Journal of Food Microbiology, 241, 252–261. https://doi.org/10.1016/j.ijfoodmicro.2016.10.035
- Rodríguez, M., G. Rebollar, P., Mattioli, S., & Castellini, C. (2019). n-3 PUFA sources (precursor/products): A review of current knowledge on rabbit. Animals, 9(10), 806. https://doi.org/10.3390/ani9100806
- Rogero, M. M., Leão, M. C., Santana, T. M., Pimentel, M., Carlini, G., da Silveira, T., Gonçalves, R. C., & Castro, I. A. (2020). Potential benefits and risks of omega-3 fatty acids supplementation to patients with COVID-19. Free Radical Biology & Medicine, 156, 190–199. https://doi.org/10.1016/j.freeradbiomed.2020.07.005
- Sato, Y., Akiyama, H., Matsuoka, H., Sakata, K., Nakamura, R., Ishikawa, S., Inakuma, T., Totsuka, M., Sugita-Konishi, Y., Ebisawa, M., & Teshima, R. (2010). Dietary carotenoids inhibit oral sensitization and the development of food allergy. Journal of Agricultural and Food Chemistry, 58(12), 7180–7186. https://doi.org/10.1021/jf100519x
- Seo, B. R., Min, K. J., Cho, I. J., Kim, S. C., & Kwon, T. K. (2014). Curcumin significantly enhances dual PI3K/Akt and mTOR inhibitor NVP-BEZ235-induced apoptosis in human renal carcinoma Caki cells through down-regulation of p53-dependent Bcl-2 expression and inhibition of Mcl-1 protein stability. PLoS ONE, 9(4), e95588. https://doi.org/10.1371/journal.pone.0095588
- Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009). Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. The Journal of Experimental Medicine, 206(1), 15–23. https://doi.org/10.1084/jem.20081880
- Shah, N. P. (2007). Functional cultures and health benefits. International Dairy JournaL, 17(11), 1262–1277. https://doi.org/10.1016/j.idairyj.2007.01.014
- Shakoor, H., Feehan, J., Al Dhaheri, A., Ali, H., Platat, C., Ismail, L., Apostolopoulos, V., & Stojanovska, L. (2020). Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas, 143, 1–9. https://doi.org/10.1016/j.maturitas.2020.08.003
- Sharifi, M., Moridnia, A., Mortazavi, D., Salehi, M., Bagheri, M., & Sheikhi, A. (2017). Kefir: A powerful probiotic with anticancer properties. Medical Oncology, 34(11), 183. https://doi.org/10.1007/s12032-017-1044-9
- Sharma, A. D., & Kaur, I. (2020). Eucalyptol (1,8 cineole) from eucalyptus essential oil a potential inhibitor of COVID 19 corona virus infection by molecular docking studies. Preprints, 2020, 2020030455. https://doi.org/10.20944/preprints202003.0455.v1
10.20944/preprints202003.0455.v1 Google Scholar
- Sheih, Y. H., Chiang, B. L., Wang, L. H., Liao, C. K., & Gill, H. S. (2001). Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. Journal of the American College of Nutrition, 20(2 Suppl), 149–156. https://doi.org/10.1080/07315724.2001.10719027
- Shi, W., Meininger, C. J., Haynes, T. E., Hatakeyama, K., & Wu, G. (2004). Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell Biochemistry and Biophysics, 41(3), 415–434. https://doi.org/10.1385/CBB:41:3:415
- Shibata, T., Nakashima, F., Honda, K., Lu, Y. J., Kondo, T., Ushida, Y., Aizawa, K., Suganuma, H., Oe, S., Tanaka, H., Takahashi, T., & Uchida, K. (2014). Toll-like receptors as a target of food-derived anti-inflammatory compounds. The Journal of Biological Chemistry, 289(47), 32757–32772. https://doi.org/10.1074/jbc.M114.585901
- Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J. S., & Jang, S. I. (2019). Anti-inflammatory effect of hydrolyzed celery leaves extract in murine primary splenocyte. Journal of Food Biochemistry, 43(9), e12970. https://doi.org/10.1111/jfbc.12970
- Shree, P., Mishra, P., Selvaraj, C., Singh, S. K., Chaube, R., Garg, N., & Tripathi, Y. B. (2020). Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants - Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)—A molecular docking study. Journal of Biomolecular Structure & Dynamics, 1–14. Advance online publication. https://doi.org/10.1080/07391102.2020.1810778
10.1080/07391102.2020.1810778 Google Scholar
- Shu, Q., & Gill, H. S. (2001). A dietary probiotic (Bifidobacterium lactis HN019) reduces the severity of Escherichia coli O157:H7 infection in mice. Medical Microbiology and Immunology, 189(3), 147–152. https://doi.org/10.1007/s430-001-8021-9
- Silva, A. F., Faria-Costa, G., Sousa-Nunes, F., Santos, M. F., Ferreira-Pinto, M. J., Duarte, D., Rodrigues, I., Tiago Guimarães, J., Leite-Moreira, A., Moreira-Gonçalves, D., Henriques-Coelho, T., & Negrão, R. (2019). Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hypertension mediated by ERK and AKT inhibition. Nutrients, 11(3), 583. https://doi.org/10.3390/nu11030583
- Sirisinha, S. (2015). The pleiotropic role of vitamin A in regulating mucosal immunity. Asian Pacific Journal of Allergy and Immunology, 33(2), 71–89.
- Sknepnek, A., Tomić, S., Miletić, D., Lević, S., Čolić, M., Nedović, V., & Nikšić, M. (2021). Fermentation characteristics of novel Coriolus versicolor and Lentinus edodes kombucha beverages and immunomodulatory potential of their polysaccharide extracts. Food Chemistry, 342, 128344. https://doi.org/10.1016/j.foodchem.2020.128344
- Somasekharan Nair Rajam, S., Neenthamadathil Mohandas, K., Vellolipadikkal, H., Viswanathan Leena, S., Kollery Suresh, V., Natakkakath Kaliyathan, R., Sreedharan Nair, R., Lankalapalli, R. S., & Mullan Velandy, R. (2020). Spice-infused palmyra palm syrup improved cell-mediated immunity in Wistar Albino rats. Journal of Food Biochemistry, 44(11), e13466. https://doi.org/10.1111/jfbc.13466
- Somerville, V. S., Braakhuis, A. J., & Hopkins, W. G. (2016). Effect of flavonoids on upper respiratory tract infections and immune function: A systematic review and meta-analysis. Advances in Nutrition, 7(3), 488–497. https://doi.org/10.3945/an.115.010538
- Song, B., Guan, S., Lu, J., Chen, Z., Huang, G., Li, G., Xiong, Y., Zhang, S., Yue, Z., & Deng, X. (2013). Suppressive effects of fisetin on mice T lymphocytes in vitro and in vivo. The Journal of Surgical Research, 185(1), 399–409. https://doi.org/10.1016/j.jss.2013.05.093
- Song, S., Peng, H., Wang, Q., Liu, Z., Dong, X., Wen, C., Ai, C., Zhang, Y., Wang, Z., & Zhu, B. (2020). Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2. Food & Function, 11(9), 7415–7420. https://doi.org/10.1039/d0fo02017f
- Spinas, E., Saggini, A., Kritas, S. K., Cerulli, G., Caraffa, A., Antinolfi, P., Pantalone, A., Frydas, A., Tei, M., Speziali, A., Saggini, R., Pandolfi, F., & Conti, P. (2015). Crosstalk between vitamin B and immunity. Journal of Biological Regulators and Homeostatic Agents, 29(2), 283–288.
- Stier, H., Ebbeskotte, V., & Gruenwald, J. (2014). Immune-modulatory effects of dietary yeast beta-1,3/1,6-D-glucan. Nutrition Journal, 13, 38. https://doi.org/10.1186/1475-2891-13-38
- Sun, X., Yamasaki, M., Katsube, T., & Shiwaku, K. (2015). Effects of quercetin derivatives from mulberry leaves: Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice. Nutrition Research and Practice, 9(2), 137–143. https://doi.org/10.4162/nrp.2015.9.2.137
- Szabó, Z., Marosvölgyi, T., Szabó, É., Bai, P., Figler, M., & Verzár, Z. (2020). The potential beneficial effect of EPA and DHA supplementation managing cytokine storm in coronavirus disease. Frontiers in Physiology, 11, 752. https://doi.org/10.3389/fphys.2020.00752
- Tanaka, S., & Ichikawa, A. (2006). Recent advances in molecular pharmacology of the histamine systems: Immune regulatory roles of histamine produced by leukocytes. Journal of Pharmacological Sciences, 101(1), 19–23. https://doi.org/10.1254/jphs.fmj06001x5
- Tang, B., Chen, G. X., Liang, M. Y., Yao, J. P., & Wu, Z. K. (2015). Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats. International Journal of Cardiology, 180, 134–141. https://doi.org/10.1016/j.ijcard.2014.11.161
- Tedelind, S., Westberg, F., Kjerrulf, M., & Vidal, A. (2007). Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease. World Journal of Gastroenterology, 13(20), 2826–2832. https://doi.org/10.3748/wjg.v13.i20.2826
- Tiwari, V., & Morya, G. C. (2018). A conceptual study on nutraceuticals in Ayurvedic perspectives W.S.R. to Rasayana. Journal of Global Biosciences, 7, 5350–5357.
- Todorovic, V., Redovnikovic, I. R., Todorovic, Z., Jankovic, G., Dodevska, M., & Sobajic, S. (2015). Polyphenols, methylxanthines, and antioxidant capacity of chocolates produced in Serbia. Journal of Food Composition and Analysis, 41, 137–143. https://doi.org/10.1016/j.jfca.2015.01.018
- Tominaga, A., Fujii, T., Okuyama, H., Taguchi, T., Kusumoto, Y., & Ono, S. (2011). Effects of edible algae on immune responses: Algae polysaccharides regulate delayed-type hypersensitivity and tumor growth. Kuroshio Science, 5(1), 59–65.
- Troen, A. M., Mitchell, B., Sorensen, B., Wener, M. H., Johnston, A., Wood, B., Selhub, J., McTiernan, A., Yasui, Y., Oral, E., Potter, J. D., & Ulrich, C. M. (2006). Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. The Journal of Nutrition, 136(1), 189–194. https://doi.org/10.1093/jn/136.1.189
- Tsune, I., Ikejima, K., Hirose, M., Yoshikawa, M., Enomoto, N., Takei, Y., & Sato, N. (2003). Dietary glycine prevents chemical-induced experimental colitis in the rat. Gastroenterology, 125(3), 775–785. https://doi.org/10.1016/s0016-5085(03)01067-9
- Tull, S. P., Yates, C. M., Maskrey, B. H., O'Donnell, V. B., Madden, J., Grimble, R. F., Calder, P. C., Nash, G. B., & Rainger, G. E. (2009). Omega-3 Fatty acids and inflammation: Novel interactions reveal a new step in neutrophil recruitment. PLoS Biology., 7(8), e1000177. https://doi.org/10.1371/journal.pbio.1000177
- Ulasli, M., Gurses, S. A., Bayraktar, R., Yumrutas, O., Oztuzcu, S., Igci, M., Igci, Y. Z., Cakmak, E. A., & Arslan, A. (2014). The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family. Molecular Biology Reports, 41(3), 1703–1711. https://doi.org/10.1007/s11033-014-3019-7
- van Bergenhenegouwen, J., Braber, S., Loonstra, R., Buurman, N., Rutten, L., Knipping, K., Savelkoul, P. J., Harthoorn, L. F., Jahnsen, F. L., Garssen, J., & Hartog, A. (2018). Oral exposure to the free amino acid glycine inhibits the acute allergic response in a model of cow's milk allergy in mice. Nutrition Research, 58, 95–105. https://doi.org/10.1016/j.nutres.2018.07.005
- Vasconcelos, F. M., Silva, H., Poso, S., Barroso, M. V., Lanzetti, M., Rocha, R. S., Graça, J. S., Esmerino, E. A., Freitas, M. Q., Silva, M. C., Raices, R., Granato, D., Pimentel, T. C., Sant'Ana, A. S., Cruz, A. G., & Valença, S. S. (2019). Probiotic Prato cheese attenuates cigarette smoke-induced injuries in mice. Food Research International, 123, 697–703. https://doi.org/10.1016/j.foodres.2019.06.001
- Vavilala, S., & D'Souza, J. (2015). Algal polysaccharides and their biological applications. Marine Algae Extracts, 26, 411–452. https://doi.org/10.1002/9783527679577.ch26
10.1002/9783527679577.ch26 Google Scholar
- Vogt, L. M., Elderman, M. E., Borghuis, T., de Haan, B. J., Faas, M. M., & de Vos, P. (2017). Chain length-dependent effects of inulin-type fructan dietary fiber on human systemic immune responses against hepatitis-B. Molecular Nutrition & Food Research, 61(10), 1700171. https://doi.org/10.1002/mnfr.201700171
- Volman, J. J., Ramakers, J. D., & Plat, J. (2008). Dietary modulation of immune function by beta-glucans. Physiology & Behavior, 94(2), 276–284. https://doi.org/10.1016/j.physbeh.2007.11.045
- Vuong, T., Mallet, J. F., Ouzounova, M., Rahbar, S., Hernandez-Vargas, H., Herceg, Z., & Matar, C. (2016). Role of a polyphenol-enriched preparation on chemoprevention of mammary carcinoma through cancer stem cells and inflammatory pathways modulation. Journal of Translational Medicine, 14(1), 1–12. https://doi.org/10.1186/s12967-016-0770-7
- Wang, J., Li, T., Zang, L., Pan, X., Wang, S., Wu, Y., & Wang, G. (2017). Apigenin inhibits human SW620 cell growth by targeting polyamine catabolism. Evidence-based Complementary and Alternative Medicine, 2017, 3684581. https://doi.org/10.1155/2017/3684581
- Wang, W., Wu, J., Zhang, X., Hao, C., Zhao, X., Jiao, G., Shan, X., Tai, W., & Yu, G. (2017). Inhibition of Influenza A Virus Infection by Fucoidan Targeting Viral Neuraminidase and Cellular EGFR Pathway. Scientific reports, 7, 40760. https://doi.org/10.1038/srep40760
- Wintergerst, E. S., Maggini, S., & Hornig, D. H. (2006). Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Annals of Nutrition & Metabolism, 50(2), 85–94. https://doi.org/10.1159/000090495
- Wójcik, R. (2010). Effect of Biolex Beta-HP on phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in rats intoxicated by cyclophosphamide. Polish Journal of Veterinary Sciences, 13(1), 181–188.
- Wu, G., Fang, Y.Z., Yang, S., Lupton, J.R., & Turner, N.D. (2004). Glutathione metabolism and its implications for health. The Journal of nutrition, 134(3), 489–492. https://doi.org/10.1093/jn/134.3.489
- Wu, Q., Liu, L., Miron, A., Klímová, B., Wan, D., & Kuča, K. (2016). The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: An overview. Archives of Toxicology, 90(8), 1817–1840. https://doi.org/10.1007/s00204-016-1744-5
- Xia, N., Chen, G., Liu, M., Ye, X., Pan, Y., Ge, J., Mao, Y., Wang, H., Wang, J., & Xie, S. (2016). Anti-inflammatory effects of luteolin on experimental autoimmune thyroiditis in mice. Experimental and Therapeutic Medicine, 12(6), 4049–4054. https://doi.org/10.3892/etm.2016.3854
- Xu, H., Zou, S., Xu, X., & Zhang, L. (2016). Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism. Scientific reports, 6(1), 1–13. https://doi.org/10.1038/srep28802
- Yang, N., Patil, S., Zhuge, J., Wen, M. C., Bolleddula, J., Doddaga, S., Goldfarb, J., Sampson, H. A., & Li, X. M. (2013). Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo. Phytotherapy Research, 27(9), 1381–1391. https://doi.org/10.1002/ptr.4862
- Yang, R., Pei, X., Wang, J., Zhang, Z., Zhao, H., Li, Q., Zhao, M., & Li, Y. (2010). Protective effect of a marine oligopeptide preparation from chum salmon (Oncorhynchus keta) on radiation-induced immune suppression in mice. Journal of the Science of Food and Agriculture, 90(13), 2241–2248. https://doi.org/10.1002/jsfa.4077
- Yao, Y., Luo, Z., & Zhang, X. (2020). In silico evaluation of marine fish proteins as nutritional supplements for COVID-19 patients. Food & Function, 11(6), 5565–5572. https://doi.org/10.1039/d0fo00530d
- Ye, H., Wang, K., Zhou, C., Liu, J., & Zeng, X. (2008). Purification, antitumor and antioxidant activities in vitro of polysaccharides from the brown seaweed Sargassum pallidum. Food Chemistry, 111(2), 428–432. https://doi.org/10.1016/j.foodchem.2008.04.012
- Yoo, H. J., You, D. J., & Lee, K. W. (2019). Characterization and immunomodulatory effects of high molecular weight fucoidan fraction from the sporophyll of Undaria pinnatifida in cyclophosphamide-induced immunosuppressed mice. Marine Drugs, 17(8), 447. https://doi.org/10.3390/md17080447
- You, S. G., Yang, C., Lee, H. Y., & Lee, B.-Y. (2010). Molecular characteristics of partially hydrolyzed fucoidans from sporophyll of Undaria Pinnatifida and their in vitro anticancer activity. Food Chemistry, 119, 554–559. https://doi.org/10.1016/j.foodchem.2009.06.054
- Zhang, C. X., Wang, H. Y., & Chen, T. X. (2019). Interactions between Intestinal microflora/probiotics and the immune system. BioMed Research International, 2019, 6764919. https://doi.org/10.1155/2019/6764919
- Zhang, Y., Liang, D., Dong, L., Ge, X., Xu, F., Chen, W., Dai, Y., Li, H., Zou, P., Yang, S., & Liang, G. (2015). Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury. Respiratory Research, 16(1), 43. https://doi.org/10.1186/s12931-015-0199-1
- Zhao, Y., Ran, Z., Jiang, Q., Hu, N., Yu, B., Zhu, L., Shen, L., Zhang, S., Chen, L., Chen, H., Jiang, J., & Chen, D. (2019). Vitamin D alleviates rotavirus infection through a Microrna-155-5p mediated regulation of the TBK1/IRF3 signaling pathway in vivo and in vitro. International Journal of Molecular Sciences, 20(14), 3562. https://doi.org/10.3390/ijms20143562
- Zheng, M., Karki, R., Williams, E. P., Yang, D., Fitzpatrick, E., Vogel, P., Jonsson, C. B., & Kanneganti, T.-D. (2021). TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines. Nature Immunology, 22, 1–10. https://doi.org/10.1038/s41590-021-00937-x
- Zhong, Y., Catheline, D., Houeijeh, A., Sharma, D., Du, L., Besengez, C., Deruelle, P., Legrand, P., & Storme, L. (2018). Maternal omega-3 PUFA supplementation prevents hyperoxia-induced pulmonary hypertension in the offspring. American Journal of Physiology-Lung Cellular and Molecular Physiology, 315(1), L116–L132. https://doi.org/10.1152/ajplung.00527.2017