Volume 239, Issue 2 pp. 87-91

Co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system

D.K. KANG,

D.K. KANG

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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M.J. SUTER,

M.J. SUTER

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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C. BOUDOUX,

C. BOUDOUX

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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P.S. YACHIMSKI,

P.S. YACHIMSKI

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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W.P. PURICELLI,

W.P. PURICELLI

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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N.S. NISHIOKA,

N.S. NISHIOKA

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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M. MINO-KENUDSON,

M. MINO-KENUDSON

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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G.Y. LAUWERS,

G.Y. LAUWERS

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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B.E. BOUMA,

B.E. BOUMA

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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G.J. TEARNEY,

G.J. TEARNEY

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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D.K. KANG,

D.K. KANG

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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M.J. SUTER,

M.J. SUTER

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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C. BOUDOUX,

C. BOUDOUX

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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P.S. YACHIMSKI,

P.S. YACHIMSKI

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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W.P. PURICELLI,

W.P. PURICELLI

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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N.S. NISHIOKA,

N.S. NISHIOKA

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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M. MINO-KENUDSON,

M. MINO-KENUDSON

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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G.Y. LAUWERS,

G.Y. LAUWERS

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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B.E. BOUMA,

B.E. BOUMA

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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G.J. TEARNEY,

G.J. TEARNEY

Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

Pathology Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A.

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First published: 14 July 2010

https://doi.org/10.1111/j.1365-2818.2010.03367.x

Citations: 11

G.J. Tearney, Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston 02114, MA, U.S.A. Tel: (617) 724 2979; fax: (617) 726 4103; e-mail: [email protected]

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Summary

Spectrally encoded confocal microscopy and optical frequency domain imaging are two non-contact optical imaging technologies that provide images of tissue cellular and architectural morphology, which are both used for histopathological diagnosis. Although spectrally encoded confocal microscopy has better transverse resolution than optical frequency domain imaging, optical frequency domain imaging can penetrate deeper into tissues, which potentially enables the visualization of different morphologic features. We have developed a co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system and have obtained preliminary images from human oesophageal biopsy samples to compare the capabilities of these imaging techniques for diagnosing oesophageal pathology.

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Volume239, Issue2

August 2010

Pages 87-91

Co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system

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Co-registered spectrally encoded confocal microscopy and optical frequency domain imaging system

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