Right Atrial Function and Right Ventricular Diastolic Function and Their Relation With Exercise Capacity in OSAS
Bang Du and Shuxin Liang contributed equally to this work.
Funding: This research was funded by Shenzhen Science and Technology Program (JCYJ20210324122410028), Open Project of State Key Laboratory of Respiratory Disease (SKLRD-OP-202403/202301), and In-Hospital Cultivation Fund of Gansu Provincial Hospital (19SYPYB-2).
ABSTRACT
Background
Right ventricular (RV) diastolic function and right atrial (RA) function are poorly characterized in patients with obstructive sleep apnea syndrome (OSAS), but may influence exercise capacity. We aimed to evaluate RA function and RV diastolic function in OSAS and study their relationship with exercise capacity.
Methods
Fifty-three patients with OSAS and thirty age- and gender-matched controls prospectively underwent echocardiography and cardiopulmonary exercise testing to investigate RV diastolic function, RA function, and exercise capacity.
Results
Altered RV diastolic function in patients with severe OSAS was indicated by the increased tricuspid valve E/e′ ratio (TV E/e′), isovolumic relaxation time (IVRT), and by the reduced RV TDI e′ velocity. The TV E/e′ correlated modestly with peak VO2 (r = −0.334, p < 0.01). Patients with severe OSAS exhibited impaired RA total emptying fraction, RA passive emptying fraction, and RA reservoir strain (RARS), with RARS being associated with peak oxygen uptake (VO2) (r = 0.451, p < 0.01 for reservoir function).
Conclusion
Altered RA function and RV diastolic function in patients with OSAS are associated with impaired exercise capacity. The correlation of RA function and RV diastolic function with exercise capacity suggests that it may be important to evaluate RA function and RV diastolic function in this population.
Open Research
Data Availability Statement
The datasets used and/or analyzed during the study are available from the corresponding author on reasonable request.
