Antihypertensive effects of the Limosilactobacillus reuteri Z09 and Lactobacillus helveticus Z11 fermented milk in spontaneously hypertensive rats
Xiaoling Song
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
These authors contribute equally to this paper.
Contribution: Conceptualization, Methodology, Data curation, Software
Search for more papers by this authorJinfeng Fu
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
These authors contribute equally to this paper.
Contribution: Software, Methodology, Data curation, Writing - original draft
Search for more papers by this authorQinchao Ding
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Supervision, Data curation
Search for more papers by this authorFeiwei Cao
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Supervision, Data curation
Search for more papers by this authorXiu Zhang
Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, College of Biological Science and Engineering, North Minzu University, Yinchuan, 750021 China
Contribution: Funding acquisition, Supervision
Search for more papers by this authorYanan Zhang
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
Contribution: Software
Search for more papers by this authorShanglei Lai
School of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Software
Search for more papers by this authorHui Zhug
School of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Data curation
Search for more papers by this authorTeresa G Valencak
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
Contribution: Data curation
Search for more papers by this authorCorresponding Author
Daxi Ren
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
College of Animal Sciences, Xinjiang Agricultural University, Urumqi, 830052 China
Author for correspondence. E-mail: [email protected]
Contribution: Funding acquisition, Supervision
Search for more papers by this authorXiaoling Song
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
These authors contribute equally to this paper.
Contribution: Conceptualization, Methodology, Data curation, Software
Search for more papers by this authorJinfeng Fu
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
These authors contribute equally to this paper.
Contribution: Software, Methodology, Data curation, Writing - original draft
Search for more papers by this authorQinchao Ding
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Supervision, Data curation
Search for more papers by this authorFeiwei Cao
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
School of Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Supervision, Data curation
Search for more papers by this authorXiu Zhang
Ningxia Key Laboratory for the Development and Application of Microbial Resources in Extreme Environments, College of Biological Science and Engineering, North Minzu University, Yinchuan, 750021 China
Contribution: Funding acquisition, Supervision
Search for more papers by this authorYanan Zhang
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
Contribution: Software
Search for more papers by this authorShanglei Lai
School of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Software
Search for more papers by this authorHui Zhug
School of Life Science, Zhejiang Chinese Medical University, Hangzhou, 310053 China
Contribution: Data curation
Search for more papers by this authorTeresa G Valencak
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
Contribution: Data curation
Search for more papers by this authorCorresponding Author
Daxi Ren
College of Animal Sciences, Institute of Dairy Science, Zhejiang University, Hangzhou, 310058 China
College of Animal Sciences, Xinjiang Agricultural University, Urumqi, 830052 China
Author for correspondence. E-mail: [email protected]
Contribution: Funding acquisition, Supervision
Search for more papers by this authorAbstract
Recent studies have shown that lactic acid bacteria (LAB) fermentation has great potential to relieve hypertension. In this study, we verified the antihypertensive effects of Limosilactobacillus reuteri Z09, Lactobacillus helveticus Z11 and their mixed fermented milk (MIX-FM) on spontaneously hypertensive rats (SHRs). Four weeks of administration showed that all three LAB fermentations had an antihypertensive effect on SHRs, while MIX-FM showed the best effect. MIX-FM had the highest angiotensin-converting enzyme inhibitor peptide contents, and it can improve intestinal dysbiosis better than the other two groups. The above results suggest that these two strains have the potential to develop antihypertensive dairy products.
Conflict of interest
The authors declare no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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