Uncovering phenotypic changes of luxS-mediated acid tolerance in Cronobacter malonaticus
Yuhang Wang
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Conceptualization, Investigation, Methodology, Project administration, Writing - original draft
Search for more papers by this authorCorresponding Author
Na Ling
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Author for correspondence. E-mail: [email protected]; [email protected]
Contribution: Conceptualization, Project administration, Funding acquisition, Resources, Supervision, Writing - review & editing
Search for more papers by this authorZongyang Li
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorBin Cheng
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorZhixiang Nie
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorHaiyan Zeng
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Contribution: Investigation, Project administration, Funding acquisition
Search for more papers by this authorCorresponding Author
Yingwang Ye
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Author for correspondence. E-mail: [email protected]; [email protected]
Contribution: Conceptualization, Methodology, Writing - review & editing
Search for more papers by this authorYuhang Wang
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Conceptualization, Investigation, Methodology, Project administration, Writing - original draft
Search for more papers by this authorCorresponding Author
Na Ling
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Author for correspondence. E-mail: [email protected]; [email protected]
Contribution: Conceptualization, Project administration, Funding acquisition, Resources, Supervision, Writing - review & editing
Search for more papers by this authorZongyang Li
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorBin Cheng
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorZhixiang Nie
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Contribution: Investigation
Search for more papers by this authorHaiyan Zeng
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Contribution: Investigation, Project administration, Funding acquisition
Search for more papers by this authorCorresponding Author
Yingwang Ye
School of Food Science and Engineering, Hefei University of Technology, Hefei, 230009 China
Provincial Key Laboratory of Microbial Safety and Health, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070 China
Author for correspondence. E-mail: [email protected]; [email protected]
Contribution: Conceptualization, Methodology, Writing - review & editing
Search for more papers by this authorAbstract
Cronobacter spp. are high acid resistance pathogens classified as Class A pathogens in powdered infant formula. Herein, we investigated the function of Cronobacter luxS in acid response. Results showed that luxS significantly increased the resistance to acid, demonstrating bacterial survival, bacterial morphology and biofilm formation. Furthermore, LuxS might enhance acid response by mediating the up-regulation of 5-methyltetrahydropteroyltriglutamate–homocysteine S-methyltransferase and homocysteine S-methyltransferase and the down-regulation of methionine adenosyltransferase in the quorum sensing pathway. Therefore, the quorum sensing pathway mediated by luxS is the key control target for Cronobacter survival in acidic environments.
CONFLICT OF INTEREST STATEMENT
The authors declare that there is no conflict of interest regarding the publication of this research manuscript.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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