Oral Heterojunction Coupling Interventional Optical Fiber Mediates Synergistic Therapy for Orthotopic Rectal Cancer
Ruiyan Li
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorDianxun Fu
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052 China
Search for more papers by this authorXue Yuan
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorGaoli Niu
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYueyue Fan
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJiacheng Shi
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYiwen Yang
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJiamin Ye
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJingwen Han
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYong Kang
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorCorresponding Author
Xiaoyuan Ji
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Medical College, Linyi University, Linyi, 276000 China
E-mail: [email protected]
Search for more papers by this authorRuiyan Li
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorDianxun Fu
Department of Radiology, Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052 China
Search for more papers by this authorXue Yuan
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorGaoli Niu
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYueyue Fan
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJiacheng Shi
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYiwen Yang
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJiamin Ye
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorJingwen Han
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorYong Kang
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Search for more papers by this authorCorresponding Author
Xiaoyuan Ji
Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072 China
Medical College, Linyi University, Linyi, 276000 China
E-mail: [email protected]
Search for more papers by this authorAbstract
Catalytic therapy has shown great potential for clinical application. However, conventional catalytic therapies rely on reactive oxygen species (ROS) as “therapeutic drugs,” which have limitations in effectively inhibiting tumor recurrence and metastasis. Here, a biomimetic heterojunction catalyst is developed that can actively target orthotopic rectal cancer after oral administration. The heterojunction catalyst is composed of quatrefoil star-shaped BiVO4 (BVO) and ZnIn2S4 (ZIS) nanosheets through an in situ direct growth technique. Poly-norepinephrine and macrophage membrane coatings afford the biomimetic heterojunction catalyst (BVO/ZIS@M), which has high rectal cancer targeting and retention abilities. The coupled optical fiber intervention technology activates the multicenter coordination of five catalytic reactions of heterojunction catalysts, including two reduction reactions (O2→·O2− and CO2→CO) and three oxidation reactions (H2O→·OH, GSH→GSSG, and LA→PA). These catalytic reactions not only induce immunogenic death in tumor cells through the efficient generation of ROS/CO and the consumption of GSH but also specifically lead to the use of lactic acid (LA) as an electron donor to improve catalytic activity and disrupt the LA-mediated immunosuppressive microenvironment, mediating synergistic catalysis and immunotherapy for orthotopic rectal cancer. Therefore, this optical fiber intervention triggered the combination of heterojunction catalytic therapy and immunotherapy, which exhibits prominent antitumor effects.
Conflict of Interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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| smll202404741-sup-0001-SuppMat.docx5.3 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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