A Highly-Efficient Type I Photosensitizer with Robust Vascular-Disruption Activity for Hypoxic-and-Metastatic Tumor Specific Photodynamic Therapy
Correction(s) for this article
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A Highly-Efficient Type I Photosensitizer with Robust Vascular-Disruption Activity for Hypoxic-and-Metastatic Tumor Specific Photodynamic Therapy
- Dapeng Chen,
- Qing Yu,
- Xuan Huang,
- Hanming Dai,
- Tao Luo,
- Jinjun Shao,
- Peng Chen,
- Jie Chen,
- Wei Huang,
- Xiaochen Dong,
- Volume 19Issue 32Small
- First Published online: August 9, 2023
Dapeng Chen
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorQing Yu
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorXuan Huang
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorHanming Dai
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorTao Luo
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021 P. R. China
Search for more papers by this authorCorresponding Author
Jinjun Shao
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorPeng Chen
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459 Singapore
Search for more papers by this authorCorresponding Author
Jie Chen
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorWei Huang
Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi'an, 710072 China
Search for more papers by this authorCorresponding Author
Xiaochen Dong
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorDapeng Chen
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorQing Yu
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorXuan Huang
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorHanming Dai
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
Search for more papers by this authorTao Luo
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021 P. R. China
Search for more papers by this authorCorresponding Author
Jinjun Shao
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorPeng Chen
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore, 637459 Singapore
Search for more papers by this authorCorresponding Author
Jie Chen
Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Nanning, 530021 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorWei Huang
Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), Xi'an, 710072 China
Search for more papers by this authorCorresponding Author
Xiaochen Dong
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, 211800 P. R. China
School of Chemistry and Materials Science, Nanjing University of Information Science and Technology, Nanjing, 210044 P. R. China
E-mail: [email protected], [email protected], [email protected]
Search for more papers by this authorAbstract
Hypoxia severely impedes photodynamic therapy (PDT) efficiency. Worse still, considerable tumor metastasis will occur after PDT. Herein, an organic superoxide radical (O2∙−) nano-photogenerator as a highly effcient type I photosensitizer with robust vascular-disrupting efficiency to combat these thorny issues is designed. Boron difluoride dipyrromethene (BODIPY)-vadimezan conjugate (BDPVDA) is synthesized and enwrapped in electron-rich polymer-brushes methoxy-poly(ethylene glycol)-b-poly(2-(diisopropylamino) ethyl methacrylate) (mPEG- PPDA) to afford nanosized hydrophilic type I photosensitizer (PBV NPs). Owing to outstanding core–shell intermolecular electron transfer between BDPVDA and mPEG-PPDA, remarkable O2∙− can be produced by PBV NPs under near-infrared irradiation even in severe hypoxic environment (2% O2), thus to accomplish effective hypoxic-tumor elimination. Simultaneously, the efficient ester-bond hydrolysis of BDPVDA in the acidic tumor microenvironment allows vadimezan release from PBV NPs to disrupt vasculature, facilitating the shut-down of metastatic pathways. As a result, PBV NPs will not only be powerful in resolving the paradox between traditional type II PDT and hypoxia, but also successfully prevent tumor metastasis after type I PDT treatment (no secondary-tumors found in 70 days and 100% survival rate), enabling enhancement of existing hypoxic-and-metastatic tumor treatment.
Conflict of Interest
The authors declare no conflict of interest.
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