Preparation of Template-Free Robust Yolk–Shell Gelled Particles from Controllably Evolved All-in-Water Emulsions
Corresponding Author
Jean-Paul Douliez
UMR1332, Biologie du Fruit et Pathologie, INRA, University of Bordeaux, Centre de Bordeaux, 33883 Villenave d'Ornon, France
E-mail: [email protected]Search for more papers by this authorAdeline Perro
University of Bordeaux, INP Bordeaux, ISM, UMR 5255, site ENSCBP, 16 av. Pey-Berland, 33607 Pessac, France
Search for more papers by this authorJean-Paul Chapel
CNRS, University of Bordeaux, CRPP, 115 av. A. Schweitzer, 33600 Pessac, France
Search for more papers by this authorBertrand Goudeau
University of Bordeaux, INP Bordeaux, ISM, UMR 5255, site ENSCBP, 16 av. Pey-Berland, 33607 Pessac, France
Search for more papers by this authorLaure Béven
UMR1332, Biologie du Fruit et Pathologie, INRA, University of Bordeaux, Centre de Bordeaux, 33883 Villenave d'Ornon, France
Search for more papers by this authorCorresponding Author
Jean-Paul Douliez
UMR1332, Biologie du Fruit et Pathologie, INRA, University of Bordeaux, Centre de Bordeaux, 33883 Villenave d'Ornon, France
E-mail: [email protected]Search for more papers by this authorAdeline Perro
University of Bordeaux, INP Bordeaux, ISM, UMR 5255, site ENSCBP, 16 av. Pey-Berland, 33607 Pessac, France
Search for more papers by this authorJean-Paul Chapel
CNRS, University of Bordeaux, CRPP, 115 av. A. Schweitzer, 33600 Pessac, France
Search for more papers by this authorBertrand Goudeau
University of Bordeaux, INP Bordeaux, ISM, UMR 5255, site ENSCBP, 16 av. Pey-Berland, 33607 Pessac, France
Search for more papers by this authorLaure Béven
UMR1332, Biologie du Fruit et Pathologie, INRA, University of Bordeaux, Centre de Bordeaux, 33883 Villenave d'Ornon, France
Search for more papers by this authorAbstract
A template-free all-aqueous bulk preparation of robust hollow capsules having a gelatin shell from all-in-water double emulsions is reported. The hot (>40 °C) quaternary system water/polyethylene glycol (PEG)/gelatin/alginate is shown to spontaneously form PEG-in-gelatin-in-PEG double water emulsion droplets having a multinuclear core. These droplets are stable upon cooling below the temperature at which gelatin gelled. In contrast, above the melting temperature of gelatin, multinuclear double emulsion droplets controllably evolve into stable mononuclear yolk (aqueous PEG)-shell (gelatin) capsules dispersed in the aqueous PEG continuous phase. It is demonstrated that the gelatin shell can accommodate negatively charged latex beads and be re-enforced by glutaraldehyde or silica. These capsules are also shown to encapsulate payloads, suggesting possible applications in microencapsulation, drug delivery, and synthetic biology.
Conflict of Interest
The authors declare no conflict of interest.
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