Multifunctional Small Molecule Fluorophore for Long-Duration Tumor-Targeted Monitoring and Dual Modal Phototherapy
Yi Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorMin Zhang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorPing Li
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhihao Han
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorLiming Wu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorTingting Li
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhaohui Wang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorWeidong Gao
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorTao Deng
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Yueqing Gu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
E-mail: [email protected]Search for more papers by this authorYi Ma
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorMin Zhang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorPing Li
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhihao Han
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorLiming Wu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorTingting Li
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorZhaohui Wang
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorWeidong Gao
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorTao Deng
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
Search for more papers by this authorCorresponding Author
Yueqing Gu
State Key Laboratory of Natural Medicines, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Road, Nanjing, 210009 China
E-mail: [email protected]Search for more papers by this authorAbstract
In this work, a specific tumor-targeted small molecular fluorophore for synchronous long-duration cancer imaging, photodynamic therapy, and photothermal therapy is synthesized. This novel fluorophore exhibits specific targeting ability in certain tumors (U87MG, MDA-MB-231, A549, etc.) based on its inherent structure and efficiently generates local hyperthermia and reactive oxygen species simultaneously for imaging-guided precise cancer therapy combining the photothermic and photodynamic effects under laser irradiation. Meanwhile, compared to traditional near infrared fluorophore, this novel fluorophore with significantly enhanced stability against photobleaching can prolong the time of tumor imaging and improve the phototherapy efficiency. This work presents a potential strategy to develop small-molecule-based cancer theranostic agents for simultaneous cancer targeting, imaging, and therapy.
Supporting Information
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