Synthesis and Fluorescent Thermoresponsive Properties of Tetraphenylethylene-Labeled Methylcellulose

Functional polymer, especially the one based on renewable and sustainable materials, has attracted increasing attention to satisfy the growing demand for the design of stimuli-responsive devices. Methylcellulose (MC) is a water-soluble derivative of cellulose, which has been widely used in many fields for its biocompatibility and biological inertness. In this work, MC is labeled by tetraphenylethylene (TPE) via azide–alkyne click reaction to obtain a fluorescent cellulose-based derivative of MC-TPE. The degree of substitution of MC-TPE is determined to be 0.074, which can be self-assembled into micelles in water with the size of 42 ± 6 nm. MC-TPE shows thermoresponsivity and thermoreversibility in size, transmittance, and fluorescence, enabling it to work as a fluorescent thermosensor. Moreover, MC-TPE exhibits nontoxicity and biocompatibility, allowing its application in MCF-7 cell imaging. Therefore, this newly functional natural polymer shows promising potentials in the fields of sensing and bioimaging.