Remineralization of Demineralized Dentin Induced by Amine-Terminated PAMAM Dendrimer
Kunneng Liang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorHe Yuan
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorJianshu Li
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
Search for more papers by this authorJiaojiao Yang
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
Search for more papers by this authorXin Zhou
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorLibang He
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorLei Cheng
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorYuan Gao
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXin Xu
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXuedong Zhou
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Jiyao Li
- [email protected]
- | Fax: +86-28-85582167
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorKunneng Liang
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorHe Yuan
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorJianshu Li
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
Search for more papers by this authorJiaojiao Yang
Department of Biomedical Polymers and Artificial Organs, College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China
Search for more papers by this authorXin Zhou
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorLibang He
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorLei Cheng
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorYuan Gao
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXin Xu
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorXuedong Zhou
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorCorresponding Author
Jiyao Li
- [email protected]
- | Fax: +86-28-85582167
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 China
Search for more papers by this authorAbstract
The remineralization of demineralized dentin with biomimetic templates is of great interest in the fields of material science and stomatology. Amine-terminated PAMAM dendrimer (PAMAM-NH2), which possesses a highly ordered architecture and many calcium coordination sites, may be a desirable template for inducing dentin remineralization. In this study, the remineralization effect of the third generation PAMAM-NH2 (G3-PAMAM-NH2) on demineralized dentin is investigated. Demineralized dentin samples are treated with G3-PAMAM-NH2 solution (1 mg · mL−1), and then immersed in artificial saliva for different periods. The results confirm that G3-PAMAM-NH2 has a good binding capacity to demineralized dentin and can induce needle-like crystals to precipitate both on the dentin surface and in the dentinal tubules. A good ability of the regenerated minerals to resist acid challenge and good biocompatibility of G3-PAMAM-NH2 are also proved. Overall, the results suggest that G3-PAMAM-NH2 is a promising biomaterial for inducing dentin remineralization.
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